June really appears to be my lucky month - our new preprint is out on @researchsquare! 😍 Together with @doctor_msc, @andrewrjlawson and many others we looked into the life history of mitochondria in the human haematopoietic system https://t.co/7qjyALrJ65. [1/x]
Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n https://t.co/KBjrDfrxlj
Peter’s departure from Sanger certainly took me by surprise, but I’m equally excited for his next chapter. A wonderful tribute by @imartincorena to someone who I, in my brief experience in this field, consider a true pioneer and even greater human. Academia will miss him dearly.
Peter Campbell leaves the Sanger Institute at the end of the year to become Quotient's CSO. A mentor and one of my favourite scientists. His foundational, profound and creative contributions to cancer genomics and somatic evolution have truly shaped those fields. [1/7]
If you are at #AACR24 and want to hear work surrounding early carcinogenesis in #lungcancer or risk prediction and prevention in #BreastCancer come and visit me at my posters on Tuesday & Wednesday! All details are in the comments 😊
Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below!
https://t.co/LWzYFYPPPV
Excited to share the first preprint of my PhD @sangerinstitute looking into the prevalence and genetic mechanisms of gene misexpression in 4,568 whole blood RNA-seq samples from the INTERVAL cohort. https://t.co/5Ia0Z1YVPR
Gene therapy is big news! https://t.co/XhEOegAjCs
and a major advance for patients with sickle cell disease (SCD) & thalassemia.
But in some recent trials, a small number of patients developed blood cancer. Our study (out in @NatureMedicine ) asked why...
https://t.co/pos7Eqiurn
Glad to see that the joint study of our team from @HDMyeloma and @DKFZ on how tumor heterogeneity drives therapy resistance in multiple #myeloma is now out in Blood https://t.co/tbNpd0l7X6 and highlighted by @uniklinik_hd https://t.co/SLvOe2YojM
So excited to share our work with @Tobioinformatic and @Lelandtlr where we used #singlecell on a large #IBD and healthy cohort to identify gastrointestinal cell types, genes and pathways associated with #Crohns disease !
https://t.co/4TG4vq6p7n
@sangerinstitute PhD students are true DNA enthusiasts, pondering the wonders of genomics anytime, anywhere. Here's a glimpse of our PhD retreat 2023 🧬 #PhDLife#DNA
Great effort by a lot of people including @OliverStegle@KarstenRippe@Simontuk and many others @DKFZ! Most importantly Alex & Nina (both do not seem to have Twitter) who managed to bring this project to completion (at least the first stage). Looking forward to whats ahead!
Concluding a scientifically fantastic June 2023, I am happy to share that our work on therapy resistance in multiple myeloma has been published in @BloodJournal! 🥳 If you are interested in multi-omics analysis of single-cell data, give it a read!
https://t.co/36yGuge5ON
June really appears to be my lucky month - our new preprint is out on @researchsquare! 😍 Together with @doctor_msc, @andrewrjlawson and many others we looked into the life history of mitochondria in the human haematopoietic system https://t.co/7qjyALrJ65. [1/x]
This was only possible due to the great help of many others - in particular @andrewrjlawson, @imartincorena, @Emily_LMitchell, @_Luke_MRH_ as well as @jyoti_nangalia and more (which I probably did not find on twitter - sorry)! [19/x]