Ainara Claveras

PhD student at @MPIbp | Theoretical biophysics

[Christina Athanasiou @ch_athanasiou]

We have a new publication @J_A_C_S
Au! We have performed long scale coarse-grained MD simulations to investigate the mechanism of activation of the transmembrane domain of neurotrophin receptors!

@Claveraas, Alexandros Tsengenes, @Rebecca_Wade_C

https://t.co/YAmUiDmsuK

[Ainara Claveras @Claveraas]

Our latest work on the activation of the PI3KC3-C1 complex is out in Science! It was great to be part of this exciting collaboration with @LazarouLab, @TheHurleyLab and @HummerLab. Big thanks to everyone involved! Check out the full paper here: https://t.co/1FgGd4msFC

[Max Planck Institute of Biophysics @MPIbp]

Autophagy ♻️ can't happen without PI3KC3-C1, a protein complex that initiates the cell’s cleanup by phosphorylating lipids 🧪 Congrats to the @LazarouLab, @HummerLab & @TheHurleyLab on their new publication!

[Ainara Claveras @Claveraas]

It was a great experience to present my work at #EMBOautophagy24 last week in Sorrento! Many thanks to the organisers for such an inspiring meeting, looking forward to the next one 🇮🇹☀️

[Ainara Claveras @Claveraas]

@MiChAeL_900922 @Nature @SafarianSchara @HummerLab @nguyenln_ So glad to be part of this great collaboration! As a little add-on, here is a short movie of how choline wiggles in the binding pocket of FLVCR2

[Max Planck Institute of Biophysics @MPIbp]

Tracking down rare diseases: Researchers from our Institute, @FraunhoferITMP, @NUSingapore, @UW & @goetheuni studied the structure & cellular function of #FLVCR proteins paving the way to understand the progression of rare diseases & develop new therapies👉https://t.co/AZF8SwkvTW

[Di Wu @MiChAeL_900922]

Happy to share our latest study in @Nature revealing how FLVCR1 & FLVCR2 transport choline & ethanolamine, and shedding light on their roles in related rare diseases. Two in One! 🔬 Read more: https://t.co/hDjQDHWIa0 Great teamwork with @SafarianSchara @HummerLab @nguyenln_ 💪

[Sergio Cruz-León @SergioCruzLeon1]

We are excited to announce the publication of high confidence 3D template matching for #cryoET
@HummerLab @Beck_Laboratory @jpkreysing @geissler_katha @s_l_schaefer @pc_hoffmann @MPIbp @cziscience

Paper's link: https://t.co/97wkNFMVhI

See it in action in our short video!

[mito911 @mito911_]

📢New @biorxivpreprint by @AutophaZeke @TheHurleyLab & colleagues @HummerLab @mito911_ @ASAP_Research reveals structural insights on PI3KC3 complexes 1 & 2 activation mechanism in #autophagy & #endosomal maturation using Cryo-EM analysis ⬇️
https://t.co/pL3yLD41sr

[Hurley Lab @TheHurleyLab]

New preprint! @AutophaZeke’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!

[Ute Hellmich @HellmichGroup]

Our recent on the TRPV4 IDR ensemble has just been featured as a research highlight in Nature Chemical Biology 🥳
https://t.co/qfU870b3JV

Fantastic news on the day that I have the pleasure to talk about this story @JohnsHopkins w @SumnerLab!

@nchembio @microverse_exc @sfb1507

[Ute Hellmich @HellmichGroup]

ThermoTRPs on🔥!
After our discovery of lipid-regulated TRPV4 IDR functional dynamics: https://t.co/86eAcdlacO

and @ScheuringLab's pentameric TRPV3: https://t.co/nTQAkhbq9x,

now @moiseenkovabell & @ScheuringLab on TRPV2 IDRs: https://t.co/w4Eghfl0bo!

Your move TRPV1 ?!?🌶️😋

[nanoCAFÉ Group @HyGate_ERC]

Ainara Claveras-Cabezudo is now presenting "Exploring TRPV4 regulation by intrinsically disordered regions through molecular dynamics simulations"

[nanoCAFÉ Group @HyGate_ERC]

Thanks to all the Speakers and Chairmen who contributed to make this event so brillant! @AlbGiacomello

[Nature Communications @NatureComms]

@HellmichGroup @UniJena present an integrated structural biology approach uncovering the structural and functional complexity of the intrinsically disordered region (IDR) within the TRPV4 ion channel.

https://t.co/ZJfsltjjEi

[Ute Hellmich @HellmichGroup]

Our paper on the structural dynamics of the TRPV4 IDR (https://t.co/BKfBAOikpY) has been selected as a featured article in the Editors’ Highlights on "Structural biology, biochemistry and biophysics" in @NatureComms !!! 🥳
@microverse_exc @profillinie
https://t.co/uLg3HW7wHE

[Ute Hellmich @HellmichGroup]

What are the true dimensions of a TRP channel?
Read more on the TRPV4 structural ensemble and the complex regulatory network encoded within the channel's N-terminal IDR: https://t.co/wxlMa2TyEe

#NMR #SAXS #MD #HDX #XLMS
@NatureComms @microverse_exc @sfb1507 @profillinie

[Max Planck Institute of Biophysics @MPIbp]

We had a fantastic #GirlsDay with 20 curious and motivated girls last week! They learned about how to investigate the smallest building blocks in our bodies. Ever extracted and looked at the #DNA of tomatoes? The girls did! 🍅🧪
@Der_GirlsDay #GirlsDay2023 #biophysics #education

[Ainara Claveras @Claveraas]

Check out this enlightening article by Taylah Andrews Clark on inequality in STEM. Despite STEM benefiting from diversity, discrimination based on gender, race, and sexual orientation still persists. Highly recommend it! #STEM #inequality

https://t.co/b8qdmOoSkd

[Kerstin Göpfrich @KGoepfrich]

@Claveraas @Rebecca_Wade_C Very interesting work, congrats & thanks for sharing!