James Cook

Carbon-based humanoid working on microglia in Alzheimer's disease. First scientist to recognise humous as an element.

[James Cook @Cooklevision]

@montividas @thejackhopkins This is such a dumb take.

The republican vote total also increased in 2020 vs 2016 by 19% - only slightly behind the Dems' increase (24%).

And MAGA are posting this everywhere as though they've cracked the fucking DaVinci code.

[James Cook @Cooklevision]

@Steve_Laws_ Yeah sure, totally nothing to do with population ageing or people having less disposable income and not drinking as much.

I stopped going to clubs not because I was scared of immigrants but because it's expensive and, let's face it, intolerable unless you're completely smashed.

[James Cook @Cooklevision]

The "for you" section of twitter is now officially 100% certified bilge.

The last few days especially I seem to be getting way more weird masculinity influencers, bizarre AI-generated shit and generic clickbait

The veneer of quality content is well and truly gone

[James Cook @Cooklevision]

@DrSarahRyan @braincomms @choyle22 @mere_conjecture @ComorbidCath @AlzSocResearch Nice one! Congrats!!

[James Cook @Cooklevision]

@comeflywithJo @NC3Rs I want them! 😄

[James Cook @Cooklevision]

@Rose_Wellens @choyle22 Amazing! Well done guys 🎉🎉🔬

[James Cook @Cooklevision]

@mike_jd_daniels Haha same in Germany actually! It takes some getting used to for sure. Luckily the drivers here are all very good at giving way...

[James Cook @Cooklevision]

@willovvens Which cluster is the stemmm cells?

[James Cook @Cooklevision]

@mike_jd_daniels Not really the same thing but the first time I moved to Germany I ended up living in the same building as a guy called Alex Assman

Lost it every time I saw his post

[James Cook @Cooklevision]

@AndrewJDoig1 @jkpritch This is precisely the problem with UMAPs - unlike a PCA, they are nonlinear with respect to the underlying data, and misrepresent the absolute variability within / between clusters.

[James Cook @Cooklevision]

This made my day... Solid gold science right there

[Veera Rajagopal  @doctorveera]

Someone used DALL-E to create gobbledygook scientific figures and submitted them to Frontiers Journal. And guess what? The editor published it. LOL
https://t.co/hjQkRQDkal

[Veera Rajagopal  @doctorveera]

Someone used DALL-E to create gobbledygook scientific figures and submitted them to Frontiers Journal. And guess what? The editor published it. LOL
https://t.co/hjQkRQDkal

[James Cook @Cooklevision]

@comeflywithJo Hahaha how did you not know about giant tubes?

They are so satisfying

[James Cook @Cooklevision]

@DrSarahRyan @AlzSocResearch @BIG_research @DNS_UOM Yay! Congrats!! 🍺🍺🥳🥳

[James Cook @Cooklevision]

@Research_Table @AmreiBahr @AKellerGEW @HRK_aktuell @starkwatzinger Absolutely mental.

I'm on my first 2-year postdoc contract. If this passes, I will have ONE more year max, after which I'll have to be offered a permanent position (lol) or leave (German) academia.

Let's hope someone in charge realises how stupid this is before it's passed.

[James Cook @Cooklevision]

Aaaaand there it is. We were all waiting for it. I think we can all see how this will go now:

Sunak: "We don't need Horizon, it's cheaper to just fund our researchers ourselves"

Researchers: "So fund us then"

Sunak: "No" https://t.co/8gmppobAMx

[James Cook @Cooklevision]

@wellens_rose @scisignal @choyle22 @drjackpgreen @UoM_GEU @BillieJMatchett @Glo_loca Congrats! Really great to see this stuff out!!

[James Cook @Cooklevision]

Great to see this paper out in @scisignal from the Brough lab!

Massive effort from a top team! 🚀🚀

[Jack Green @drjackpgreen]

Check out our latest research - Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome - https://t.co/sH42wKhn50
Huge team effort! 🥳

[James Cook @Cooklevision]

@Divyank_Mahajan @mdziemann Not exactly. This is a different issue to over/under expression.

If you want to claim that eg. genes involved in lysosome function are overrepresented in your upregulated gene set, you must correct for their overall frequency in *your* dataset, not just in the entire genome.

[James Cook @Cooklevision]

@MilenaSchonke @mdziemann You can define the background as all genes with expression above a certain threshold in at least X many samples, be they treated or untreated, mutant or control etc..

That way you don't miss genes which are highly dependent on your treatment.