Dirk Grosse Meininghaus

Father, Husband, Physician, Cardiac electrophysiologist
Head of Cardiology, Carl-Thiem-Hospital Cottbus gGmbH

[John Mandrola, MD @drjohnm]

The authors are candid:
"the reality is sobering: the current clinical results remain underwhelming and the justification for widespread reimbursement is questionable given the modest outcomes reported in published trials..."

https://t.co/lsQoLQjgkd

[Mounir Basalus (Ⲃⲁⲥⲓⲗⲓⲟⲥ) @Basalus]

4️⃣ The Bottom Line:
PFA is emerging as the safest option for PVI, significantly reducing esophageal complications compared to traditional thermal methods. A new era in ablation? [6]

📚 References:
1.Wolf M et al. Heart Rhythm 2019
2.Hartl S et al. J Clin Med 2022
3.Francke A et al. JCE 2022
4.Halbfass P et al. Europace 2022
5.Cordes F et al. Sci Rep 2021
6.Grosse Meininghaus D et al. JCE 2024

[Emmanuel Ekanem @E_EkanemMD]

The MANIFEST-17K study, largest registry of PFA, is now published in Nature Medicine!
Congratulations to the entire MANIFEST-17k consortium for their contributions to this momentous study!
@VivekReddyMD @MohitTuragam

https://t.co/E0B8qy4ttW

[Dirk Grosse Meininghaus @DGroMein]

@dambrox Thank you 🙏

[Dirk Grosse Meininghaus @DGroMein]

Very happy and proud to complete my Habilitation-thesis on “Esophageal complications of atrial fibrillation ablation” on April 22nd, 2024 with a scientific lecture at Faculty of Health Sciences Brandenburg. Thanks to my mentors and my family.

[Heart Rhythm Society @HRSonline]

Have 🤯 science to share with the #globalEP community? Submit it for #HRS2024! Abstract presenters enjoy 50% off registration, not to mention the chance to present their work at the biggest EP event of the year!

SUBMIT ABSTRACTS > https://t.co/LEsaSiARWw

#EPeeps #CardioTwitter

[Emmanuel Ekanem @E_EkanemMD]

MANIFEST-17K study is the largest registry of PFA to date: 17,642 pts/ 106 sites.
-Major complication rate of 1%- No AE fistula/PV stenosis
-Coronary spasms were rare but can be associated with VF
-Previously unreported AE-Hemolysis with renal failure (0.03%)

[Dirk Grosse Meininghaus @DGroMein]

Das Klinikum - Aktuelles - Carl-Thiem-Klinikum Cottbus gGmbH https://t.co/VFeNNI8hJP

[Heart Rhythm Society @HRSonline]

EPISODE 6 OUT NOW!

🎤 A Discussion of a Worldwide Survey on Incidence, Management & Prognosis of Esophageal Fistula Formation Following #AFib Catheter Ablation: The #POTTERAF Study

Listen on your preferred podcast platform > https://t.co/cGP4MHk6gZ

#EPeeps #podcast #Medpodcast

[Dirk Grosse Meininghaus @DGroMein]

@TinaBaykaner Rare cases but occasionally found. Our case report of an implantation in 2019 https://t.co/ZEhZtxyrfg The patient is doing well with optimal CRT response following two explantations for suggested infection within one year. It turned out to be metal allergy solved by gold coating.

[Tolga Aksu, MD @MDTolgaAksu]

Intrinsic Cardiac Neuromodulation in Management of AF- A Potential Missing Link?
https://t.co/2wcsJme8Jg
*The schematic view of GPs
*EGM types for GP mapping
*Adv and disadv of GP mapping techniques
* Summary of RCTs
@DhirajGuptaBHRS

[Dirk Grosse Meininghaus @DGroMein]

@purerfellner Congratulations, Dr. Pürerfellner. Your results make me happy. There must be a role of substrate modification in persistent AF. We just have to learn to identify the patients who profit from PVI plus, and to isolate those areas (including epicardial insertions). Great results.

[Less-Is-More Cardiologist @DavidLBrownMD]

Family consult. 65yo active male with 2 recent syncopal events, inc 1 while driving. Long pauses during sleep but not while awake. Echo, stress test normal Plan: PPM
Me: when's the PPM?
Him: after my cath
Me: Why a cath?
Him: My cardiologist just wants to make sure
Me: Ugh

[peterkistler MBBS PhD FHRS @peterkistler3]

Post wall connections in 59% and unacceptable complication rate 14.8! with hybrid surgical approach https://t.co/xHDR3CVfzj

[Nathaniel Steiger @TheSteigasaurus]

Heat stacking answers! How can we deliver RF to mitigate esophageal heating? We found interrupted lesions with HPSD minimized heating @True_EP @paulzei @utedrow @JorgeERomeroMD @EPentraining @OmarKreidieh1 @JohnWhitaker20 @PierreChengQian @DrKoplan https://t.co/LuCIdNZi1j

[Dominik Scharpf @dscharpfMD]

Fortbildungstipp 🔥

Auf dem #ESCCongress wurden viele Studien vorgestellt die Einfluss auf den kardiologischen Alltag haben werden.

Die Kongress-#highlights diskutieren Prof. @thiele_holger & Prof. Hindricks am Mittwoch um 19-21 Uhr auf #YouTube ⬇️

➡️ https://t.co/wGpBNMK9lJ

[Heart Rhythm Case Reports @HRS_CaseReports]

Asymptomatic Esophageal Perforation Following High-Power Short-Duration Pulmonary Vein Isolation – A case of conservative cure https://t.co/MSw4Gz3rBq

[Dirk Grosse Meininghaus @DGroMein]

Besides ablation parameters and thermal side effects, preexisting vulnerability (chronic inflammation) is relevant for PVI-associated esophageal injury.
Proud to have our Paper accepted in Clinical Research in Cardiology, full text available online with https://t.co/6ODVoSKkpB

[Dirk Grosse Meininghaus @DGroMein]

1.Including periesophageal edema, HPSD (50W, 13s) ablation may also be associated with thermal esophageal damage.
2.Calculated temperature parameters (area-under-the-curve) had a high positive and negative predictive value for esophageal injury.

[Dirk Grosse Meininghaus @DGroMein]

Proud to have our paper “Calculated Parameters of Luminal Esophageal Temperatures predict Esophageal Injury following Conventional and High-Power Short-Duration Radiofrequency Pulmonary Vein Isolation” accepted by JCE and already published online (https://t.co/wFbaJB3FXj).