Dalia Fleifel

PhD in Biochemistry and Biophysics '25 @UNC_BCBP. Cell cycle, DNA replication, genome stability, Epigenetics📍UNC CH, USA. 🇪🇬❤

[Dalia Fleifel @DaliaFleifel]

I am deeply grateful for Dr Ahmed Zewail for establishing @_ZewailCity_ and giving many people the chance to conduct high caliber research in Egypt. I owe him a lot! ❤

[The Nobel Prize @NobelPrize]

Remembering the founder of femtochemistry, Ahmed Zewail, who was born #OTD in 1946. Zewail was awarded the 1999 #NobelPrize in Chemistry "for his studies of the transition states of chemical reactions using femtosecond spectroscopy."

Learn more: https://t.co/SEQWabP9ni

[UNC School of Medicine @UNC_SOM]

Ever wonder how your cells know when to grow, copy their DNA, and split in two —and what goes wrong in cancer? Meet the Cook Lab at UNC SOM. The research team studies the cell division cycle & trains the next generation of scientists. Watch here for more: https://t.co/NKpRmASlXa

[UNC Biochemistry and Biophysics department @UNC_BCBP]

🚀 Exciting News! 🚀 New video showcasing our innovative research is dropping soon. Stay tuned next week on the @UNC_SOM website & social channels. 🌟 Dr. Jean Cook's lab members share insights into their vital work #BasicScienceResearch #CancerResearch #CellCycle @DaliaFleifel

[UNC Lineberger @UNC_Lineberger]

Today at #AACR25, Dalia Fleifel will present during the poster session: (Poster 3) Unraveling c-MYC role in DNA replication origin licensing through non-canonical pathways

⌚️: 2 – 5 p.m. CT
📍: South Hall A

[UNC Biochemistry and Biophysics department @UNC_BCBP]

Grad students Dalia Tarek Fleifel (Cook lab) & Humeyra Kaanoglu (Sancar Lab) presented their research posters at the American Association for Cancer Research (AACR) annual meeting in Chicago.
https://t.co/T088ejneBJ

[UNC Biochemistry and Biophysics department @UNC_BCBP]

@DaliaFleifel receives the @AACR Scholar-in-Training Award! This recognition is based on the quality of her award application and her abstract titled “Unraveling c-MYC role in DNA replication origin licensing through non-canonical pathways. https://t.co/Z0E3tScAwb

[Dalia Fleifel @DaliaFleifel]

@proud_rpcv Thanks Juanita 😍

[Dalia Fleifel @DaliaFleifel]

Honored to be selected by the UNC BCBP community for this year's Dianne Harris Graduate Student Award for exemplary leadership. Many thanks to the BCBP community and specifically the Cook lab for making this possible!

[UNC Biochemistry and Biophysics department @UNC_BCBP]

Congrats to Dalia Fleifel, PhD Candidate, who received the Dianne Harris Graduate Student Award for exemplary leadership in the department of Biochemistry and Biophysics! @DaliaFleifel

[Dalia Fleifel @DaliaFleifel]

@chromajain @DrBrianStrahl Best of luck Kanishk in your new exciting phase 🌟

[Abdalla Alkhawaja @AbdullahAmr3]

Excited to share that I'm presenting my research at this year's American Society of Human Genetics #ASHG24 meeting! 🧬 (1/5)

[Dalia Fleifel @DaliaFleifel]

2 days of inspiring convos and fantastic science with Dr Nogales at UNC!

@NogalesLab

[UNC Biochemistry and Biophysics department @UNC_BCBP]

Wrapping up an amazing 2-day visit with Dr. Eva Nogales for our Mary Ellen Jones Distinguished Women in Science Lecture Series. Her career talk was truly inspiring: ‘I never considered the option of giving up.’ Huge thanks to our grad student hosts Dalia, Gracie, and Derek & all!

[UNC Biochemistry and Biophysics department @UNC_BCBP]

Today and tomorrow! 2024 Mary Ellen Jones Distinguished Women in Science Lecture series with 2023 Shaw Prize Laurate, Professor Eva Nogales!

[Robertus de Bruin @DeRobertus]

Virtual Cell Cycle Club meeting, Tuesday, October 15.

PROGRAMME
3 short talks: @dnatarheel, @MansfeldLab & the @Alexis_Barr labs
6 breakout sessions talks (t.b.c)!!
1 Keynote: @BettencourtDias

Don't miss out!
Register (for free!) using the link below: https://t.co/WlI4UZoygs

[Dalia Fleifel @DaliaFleifel]

Excited to give a talk tomorrow Tuesday Oct 15 at the virtual Cell Cycle conference!

[Abcam @abcam]

Join us online on October 15 for the final instalment of the #CellCycleConference for 2024! Browse talks and speakers below, and click here to register for free 👉 https://t.co/X4RGMCrSuP @DeRobertus

[Dalia Fleifel @DaliaFleifel]

Keep shining 🌟♥️ @AbdullahAmr3

[Abdalla Alkhawaja @AbdullahAmr3]

I am grateful that I won the award for the best oral presentation in the Bioinformatics and Computational Biology (BCB) program during the Annual UNC Genetics Retreat 2024!

[Dalia Fleifel @DaliaFleifel]

And also complememtary work from the Stewart, Walter and Jackson labs.

https://t.co/KxriP1Rgj8

[Dalia Fleifel @DaliaFleifel]

Preprint alert 📢

Excited to share my co-first author preprint describing a collaborative work to identify a new role for USP37 in antagonizing replisome disassembly!

[bioRxiv Cell Biology @biorxiv_cellbio]

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination https://t.co/qKXOEOq8DI #biorxiv_cellbio

[Dalia Fleifel @DaliaFleifel]

Complementary work from the Labib lab https://t.co/6daPYL0DwF

[Thomas Bonacci @thomas_bonacci]

Kudos to my amazing co-first authors Derek Bolhuis and @DaliaFleifel, co-authors Xianxi and Brandon, as well as co-corresponding authors @dnatarheel, Nick Brown and @memanuele123

[Dalia Fleifel @DaliaFleifel]

@thomas_bonacci @dnatarheel @memanuele123 USP37 is known to be overexpressed in several cancers, hinting at its critical role in cancers with high levels of replication stress. Thus, USP37 function in antagonizing replisome disassembly can be exploited in cancers to induce even more replication stress.

[Dalia Fleifel @DaliaFleifel]

@thomas_bonacci @dnatarheel @memanuele123 Through neat biochemical work, we show that USP37 interacts with the replisome and directly deubiquitinates MCM7. Interrstingly, we show that USP37 is essential for cells that overproduce the oncoproteins cyclin E1 or c-MYC, where its depletion severely undermines cell fitness.