Mansfeld Lab

PTM and cell proliferation lab at the @ICR_London. Tweets are from anyone in the lab :-)

[Giovanni E Mann @mann_ivel]

UK REDOX NETWORK 2025 Meeting at Institute of Cancer Research, London SW7 3RP28 April 2025. Excellent programme coordinated by Olena Rudyk (KCL) and Joerg Mansfeld (ICR). @SFRR_Europe @kingscardio @elsbiomedchem

[Mansfeld Lab @MansfeldLab]

Have you ever wondered what H2O2 does in your cells? We are looking a highly motivated #Postdoc to investigate #Redox regulation of #DNAReplication and #DNADamage repair. Our lab is based at the ICR in Chelsea, London, UK. Please apply here: https://t.co/P0k77EgMWD #mansfeldlab

[Giovanni E Mann @mann_ivel]

UK REDOX NETWORK Meeting Session 2: Helena Cocheme (Imperial College) introduces Joerg Mansfeld (Institute of Cancer Research) (https://t.co/lTfWCmnYHg…; @SFRR_Europe @SFRRAustralasia @SFRBM @CochemeLab @JuliaVorhauser

[Mansfeld Lab @MansfeldLab]

@MickLab Excellent News. Very happy for you!

[Mansfeld Lab @MansfeldLab]

@DoraTang5 @ERC_Research Congratulations Dora so well deserved!

[Anna Poetsch @APoetsch]

We have several postdoc openings!
https://t.co/KnVthk40zI
Our interdisciplinary group works on the #Genomics of #DNAdamage and #Mutagenesis using #ComputationalBiology, #MachineLearning and #AI.
(details in following tweets)

[Michael Yaffe @mbyaffe]

An extraordinary paper showing an unexpected redox role for BCAT1 in accurate chromosome segregation. There is clearly something important about how redox changes modulate the cell cycle, especially in mitosis. https://t.co/Rn6AVjAejQ

[Sebastian Guettler Lab @SGuettlerLab]

How does polymerisation activate the ADP-ribosyltransferase tankyrase? We are a few steps closer to the answer: https://t.co/wdwB73eiae. Congratulations to the team, and thank you to our funders, especially @CRUKresearch @wellcometrust @ICR_London @ListerInstitute!

[Mansfeld Lab @MansfeldLab]

@NatrajanLabICR @ICR_London @BreastCancerNow Congratulations Rachael, what a rollercoaster since that Thursday. Well-deserved!!

[Alex Radzisheuskaya @AliaksandraR]

I am thrilled and honoured to be one of the #ERCStG recipients! So grateful to @ERC_Research, my mentors, colleagues at the @ICR and my family. We will explore the roles of histone acetylation in cancer and will be recruiting soon.
https://t.co/Q6iCmxydJF

[Pines lab @PinesLab]

Many congratulations to Alex Radzishueskaya in our Division who has been awarded an ERC Starting Grant!

[Stephan Hacker (inactive account) @StephanHacker2]

Interesting @biorxivpreprint by the group of Ben Cravatt @scrippsresearch with the group of @davidrliu. They use base-editing to assign essentiality to >10,000 cysteines in cancer cell lines. Full post on @joinmastodon @[email protected]. https://t.co/S3FfMJcV3o

[Mansfeld Lab @MansfeldLab]

The @MansfeldLab just returned from the EMBO “Thiol in oxidation in biology” meeting. Super exciting and at a wonderful place. And @JuliaVorhauser won the POSTERPRIZE. Thanks to Bruce Morgan, Haike Antelmann and @dana_reichmann for organising one of the best workshops this year.

[Negar Afshar @NegAfshar]

If you're interested in telomeres and DNA replication, check out this amazing postdoc opportunity in Max Douglas's lab !

https://t.co/YesE040gPA

[NordenLab @NordenLab]

The @NerliElisa strikes again! Deterministic and probabilistic fate decisions exist in the same retinal lineage! A tour de force and amazing team effort led and guided by Elisa. She will discuss in more detail, I go on conference and vacation :-). https://t.co/mFVwrRBlVg

[The ICR @ICR_London]

Professor Chris Bakal's lab (@BakalLabICR) show that #Melanoma #SkinCancer cells harness ARHGEF9 - a gene usually used by growing nerves - to drill through surrounding tissues and escape from their immediate area.

Read more: https://t.co/KU2FQA01uY

[Mansfeld Lab @MansfeldLab]

Our article on a ROS-dependent regulation of CDK2 (https://t.co/5QjSh43AGh) has just been recommended on @FacultyOpinions https://t.co/CqEuhxZigs
Thanks verybody
@MansfeldLab & @BIOTEC_TUD
& @ICR_London to make this a worthwile and exciting endeavour.

[The ICR @ICR_London]

📢 NEWS: ICR scientists (@MansfeldLab) have discovered how naturally occurring, unstable molecules, known as free radicals, can directly regulate a key protein for cell division called CDK2, opening up a potential new way to target #Cancer 👇
https://t.co/SCF5jfIIsw

[🧬 The Coster Lab 🔬 @CosterLab]

📢 Hot off the press 📢

🧬 Ever wonder why some DNA sequences are difficult to replicate?

Using reconstituted replisomes we revealed that structure-forming repeats induce robust replication stalling and uncovered structure-specific recovery mechanisms:
https://t.co/BajNVcpT9w

[Mansfeld Lab @MansfeldLab]

@PinesLab Thank you :-) Happy to be part of the team @ICR_London!