Thomas Bonacci

Research assistant professor in the Pharmacology department at UNC. Studying the role of deubiquitinating enzymes in cell cycle control.

[Wolf Prize @WolfPrize_]

“For groundbreaking discoveries of the immune system and disease resistance in plants.”:
Jeffery Dangl, Jonathan Jones, and Brian Staskawicz, Wolf Prize Laureates in Agriculture 2025, have revolutionized our understanding of plant immunity and disease resistance.
Celebrate their transformative work in shaping sustainable agriculture!
@TheSainsburyLab @PMB_Berkeley @UNC_Biology @HHMINEWS
#wolfprize2025
#wolfprizelaureate #wp2025laureate #wp2025agriculture #wp2025

[Blossom Damania 🔬🧬🧪🦠🧫 @DamaniaLab]

NIH funding creates medicines, jobs, and economic growth

[Vincenzo DAngiolella @VdangioE3lab]

Very happy to have participated to this fantastic work by @brian_b_liau and Ning Zheng, which sheds an electron microscopy light on the mechanism of KBTBD4 mutant recognition of CoRest. Substrate diversification of E3s by mutations
https://t.co/6fxs6WPXZH

[Qing Zhang @QingZhangLab]

Glad to share our study from my lab led by @ChenghengLiao (also co-corres) on establishing BBOX1 tumor suppressor signaling in kidney cancer @NatureComms https://t.co/LmmMK1G68i , special thanks to @jeremy_m_simon @MalladiLab @PayalKapur5 @JBrugarolas and Deberardinis lab!

[Rashmi Agrata @Rashmi_Agrata]

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩:
Excited to share our review article in @MolecularCell , diving deep into everything #ubiquitin

Read here 👉 https://t.co/i30YRMmGi1

@CellPressNews
@WEHI_research @komander_lab

[BryanRoth @zenbrainest]

Congrats to the team: especially @gori7873 and Brian Krumm from @RothLabUNC and Adrien and Matan from Greg Scherrer's lab!!
A ton of work!
Structure-guided design of a peripherally restricted chemogenetic system: Cell https://t.co/B4YiT1BncS

[Dalia Fleifel @DaliaFleifel]

Preprint alert 📢

Excited to share my co-first author preprint describing a collaborative work to identify a new role for USP37 in antagonizing replisome disassembly!

[Thomas Bonacci @thomas_bonacci]

Kudos to my amazing co-first authors Derek Bolhuis and @DaliaFleifel, co-authors Xianxi and Brandon, as well as co-corresponding authors @dnatarheel, Nick Brown and @memanuele123

[Thomas Bonacci @thomas_bonacci]

Happy to share our newest preprint: we identified the DUB USP37 as a regulator of DNA replication, by preventing ubiquitin-mediated replisome disassembly. This establishes USP37 as critical for the maintenance of replisome during S-phase. Check it out!

[bioRxiv Cell Biology @biorxiv_cellbio]

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination https://t.co/qKXOEOq8DI #biorxiv_cellbio

[michael emanuele @memanuele123]

Happy to share a new paper from the lab, with lots of cool science to be excited about.
https://t.co/mYGzZR2hnP

[michael emanuele @memanuele123]

Bittersweet day of goodbyes! First to rock-star graduate student @rmouery1995, who is leaving for his postdoc. Second to summer student @Helenlarkin04, who will return to Clemson. Celebrated, of course, with cake and friends @jmgonzdalm @aponteamy @thomas_bonacci

[Robert Ferris, MD, PhD @RobertFerrisMD]

I am honored and excited to join UNC Lineberger and UNC health, to make an impact across the Triangle and state of NC, reducing the burden of cancer and advancing research and cancer treatment! Amazing team and strong legacy of directors Earp, Sharpless and Pagano.

[Thomas Bonacci @thomas_bonacci]

I am now looking forward to presenting this work at the Ubiquitin and Ub-like meeting in Niagara Falls in two weeks 🗓️

[Thomas Bonacci @thomas_bonacci]

I'm ecstatic to share our newest preprint: we report on the identification of new functional surfaces that explain the specificity of USP18 towards ISG15. Check it out if you like DUBs, biochemistry and AlphaFold :-)

[biorxiv_biochem @biorxiv_biochem]

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41 https://t.co/XO3QrIMArn #biorxiv_biochem

[FASEB @FASEBorg]

Have you registered for our Ubiquitin and Ub-like Proteins conference yet? Register on or before April 28 and save $150 on registration! Join organizers @kyliejwalters, @LabJoazeiro, and Yue Xiong, PhD, in Niagara. #UBPSRC
Save your space: https://t.co/qjWOe4hbbV

[BBSP @ UNC @UNCBBSP]

The mentoring skills of @Cole_Martin_00 cannot be eclipsed. This PhD Candidate in @UNC_PHCO is receiving today's shoutout for his ability to help mentees feel like they're active contributors to research.

[Stanford University @Stanford]

Jonathan Levin, a distinguished economist and Stanford alumnus who has led the Stanford Graduate School of Business as dean for the last eight years, has been appointed the next president of Stanford University, the Board of Trustees announced today. https://t.co/5WExsT8cWh

[Thomas Bonacci @thomas_bonacci]

@EHollville @acmedsci @aberdeenuni @AbdnLifeScience @neural_lab @integrintraffic Keep killing it Émilie! Congrats 😃

[Tim Stearns @StearnsLab]

Susumu Tonegawa’s Nobel lecture from 1987 about the genetic basis of antibody diversity is a great example of technology driving discovery. Each new molecular biology advance - cloning, Southern blots, sequencing - enabled the next discovery. https://t.co/JSwjxEF4MS

[Aleksandra Skrajna @a_skrajna]

Happy International Day of Women and Girls in Science!!!