Dan Dempe

[Malaria Consortium @FightingMalaria]

This #UHCDay, read our Q&A with Dr George Upenytho, Uganda’s Commissioner of Community Health, to find out why a strong community health system is crucial for equitable access to strengthened primary healthcare in Uganda: https://t.co/GNWcZ3nd0z

[Dan Dempe @DanDempe]

@AndrewBrownPgh @4meatnpotatoes Absolutely wild that there is not a single open business in downtown Pittsburgh!

[Covalent Modifiers @CovalentMod]

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin https://t.co/Hbb1IfpTPY

[drug hunter @drughunter_com]

STX-721: EGFR Ex20ins Inhibitor with Potential Best-in-Class Selectivity

An excellent case study in covalent drug discovery with respect to lead generation, selectivity based on protein dynamics, and PK optimization of covalent compounds.

Full article: https://t.co/6Q4fNx9HL7

[Koide Group @KazunoriKoide]

We @Pitt_Chemistry report the synthesis, conformational analysis, and anticancer activity of splicing modulators (open access)

Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers https://t.co/X1IpYdXWy7

[David MacMillan @dmac68]

Stunning piece of chemistry. A really elegant application of previous findings from Zhiwei’s Zuo’s lab. https://t.co/nPu2J32EGp

[Organic Chemistry Portal @organic_portal]

https://t.co/UZGcoasmxv
A convenient visible-light-induced reaction of isocyanides, thiols, and water provides various thiocarbamates under mild reaction conditions

[Wickens Group @WickensGroup]

Check out our new hydrocarboxylation story! We found our previous system was ineffective for challenging unactivated alkenes but, using a mechanistically-guided approach, we develop a new catalytic system that unlocks this substrate class. Out in @J_A_C_S https://t.co/dQEtpOfNwp

[Practical_Fragments @PracticalFrag]

Here's an #FBDD focused round-up of the @CHI_Healthtech Drug Discovery Chemistry conference in San Diego last week. Ways to find and assess covalent fragments, success stories, and a suite of techniques for E3 ligases and difficult targets
https://t.co/Ks3COkTxcY

[Chemistry Net @Chemistry_Net]

C-N Ring Construction Rh2(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins Using Nonactivated N Atom Precursors https://t.co/RDGd4LAfVf… #chemistry #bioinformatics #OrganicChemistry #Aziridines

[Baran Lab @BaranLabReads]

The final version of this work has appeared in @J_A_C_S today: https://t.co/89ZnVmBCgR

[Jamie @mccabedunn]

It was an honor to receive the WCC Rising star award with my former colleague and friend @DanicaRankic and to have my #Wolfpack member @NikkiG_Conshy there to support us!

[Baran Lab @BaranLabReads]

The 2023 edition of Heterocycles is coming on April 3 (see attached syllabus)! This year will be a reverse classroom format wherein new material will be discussed with problem solving sessions including real-world consulting questions. Please review the 2021 lectures on our YouTube channel (https://t.co/lEsCz2ZUId) before attending to maximize learning outcomes. Primary textbook available here: https://t.co/2VyqAlR2VB.

Outside participants are welcome to join over Zoom. As in previous years, those from industry are encouraged to send their problems in advance (after scrubbing IP) for us to solve during class. Please contact Brendyn Smith for the Zoom link ([email protected]) and any other questions you may have.

[Enamine Ltd 🇺🇦 @EnamineLtd]

NEW REAGENT in stock EN300-39854451
(Aggarwal, 2019) https://t.co/MmbUAMNKVV

More details: https://t.co/ZgRpHzJfQV

#Enamine #molecule #chemistry #science #drugdiscovery

[Pitt Basketball @Pitt_MBB]

MOVING. ON.

[Dr. Rachel Lippert @RachelLippert]

This is insane. Basically Germany has now said that postdoc contracts cannot last longer than three years, and after that, they have to be offered permanent positions (of which no one proposed how to generate). Even my own position now would seemingly be illegal. 🤦🏻‍♀️🙈

[Kay Brummond @KayBrummond]

The Brummond team is excited to share recent advances in the Rh(I)-catalyzed allenic Pauson–Khand reaction https://t.co/BUaB8hSlNG @OrgSynth, #OrgSynth100thVolume Please check it out! Org. Synth. 2023, 100, 29-47.
@Pitt_Chemistry

[Covalent Modifiers @CovalentMod]

Targeted Protein Degradation through E2 Recruitment [@DanNomura] https://t.co/ZAhDImaBIv

[Peng Liu Group @pengliu_group]

Our group's 200th paper! We are also excited to end 2022 with another great collaboration w/ @EngleLab Happy holidays, everyone!

[Dan Dempe @DanDempe]

@DanHarki @UMNChemistry @_ChemKat @MonteRosaTx Congratulations Cat!