Today out in @biorxivpreprint we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with @JShendure's lab. https://t.co/ovGaBmQB1V
Pleased to report the results of our clinical trial: Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung #JCO#EGFR
https://t.co/gFT1kM0M9E
Thank you to all of the patients who participated.
Very proud to have this work finally out in @NatureGenetics! This was a wonderful team effort; I would like to thank Manasi Mayekar and @BivonaLabUCSF. It was a privilege to work with our collaborators @drmcaswell and @CharlesSwanton from @TheCrick!
Our latest paper is out now in @NatureGenetics! We investigate how APOBEC3B affects EGFR mutant non-small cell lung cancer evolution, from tumor initiation to targeted therapy resistance.
https://t.co/E5RS66qTEC
A groundbreaking work from Revolution Medicine - molecular glues that disrupt native PPIs in KRas signaling. Indeed this is an exciting era for small molecule drug discovery.
https://t.co/LTRT9m1IpA
Our study on single-nucleus and spatial profiling of pancreatic cancer was published today @NatureGenet and will be the cover story in the August issue: https://t.co/stMOT1NZYc.
I am thrilled to share our recent publication in @Nature, on the Structure of the SHOC2:PP1C:RAS complex, unraveling a lingering 20 year old mystery in the most mutated oncogenic pathway in all cancers.
https://t.co/4oRi4nzDMb
Making a splash on the cover of @CD_AACR – a characterization of our structurally novel, experimental covalent KRASG12C inhibitor, with updates on studies to date investigating the drug as a potential monotherapy and in combination with a SHP2 inhibitor https://t.co/ek5zodDUFN
Please read our latest work from @Shigeki04860554 out now in @jclinicalinvest: Inactivating genetic alteration of mRNA splicing factor RBM10 co-occuring with mutant EGFR limits EGFR inhibitor response in lung cancer https://t.co/QEBLC8QXrn
Out today in @ScienceMagazine, the Tabula Sapiens is 1 of 4 new open-access cross-tissue human cell atlases. This is a major milestone for #singlecell biology, giving us a deeper understanding of the human body and the diseases that afflict it. https://t.co/WTx2ZFsoHu
Our latest manuscript, “Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome,” is now published at BioRxiv. https://t.co/njKnYzSKN0
4/13 9:00 am CR | @DanielLucasKerr@BivonaLabUCSF presents "Spatially resolved transcriptomics of cellular architecture in EGFR-mutated lung cancer" at Session: Gene Expression and the Microenvironment [Section 12 #8] https://t.co/JBPG3CVBXC