Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
It feels very futuristic to imagine a world with one-and-done therapies that lower LDL cholesterol for life, but... it might not be far off!
These are new phase 1 data for Verve/Lilly's PCSK9 base editor: one single intravenous infusion reduces LDL cholesterol by as much as 60%
‼️ Landmark #lungcancer research published today in Cell
Scientists at the Francis Crick Institute and UCL have discovered a 14-protein blood signature that predicts lung cancer more than 5 years before diagnosis, works in never-smokers, and could identify who benefits from prevention treatment.
People with high levels of these proteins were the ones who actually benefited from a drug to damp that inflammation down, cutting their lung cancer risk nearly in half.
This could finally give us something lung cancer has never had: a way to prevent it in the people most at risk.
https://t.co/SaZwBHnxvZ
#LCSM
The body responds to intensity more than duration.
Even ~4.4 minutes of vigorous daily movement associates with ~26–30% lower mortality risk
https://t.co/0RmbHKNDU2
Slowing aging is not theoretical. In humans, calorie restriction measurably slows biological aging pace by ~2–3% over 2 years
Link here: https://t.co/Eg8wBzhDpQ
Honored to be the Takeru Higuchi Lecturer of 2026. Previous speakers - Laureates Arthur Kornberg, Gertrude Elton, Aaron Ciechanover, and heroes of mine, Judah Folkman & Craig Venter
Exclusive: A longevity biotech co-founded by Coinbase’s CEO more than tripled in value to $3.1 billion—before its drugs begin human testing. https://t.co/g61a8OC1FE
Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.
NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).
Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.
The reason most people never start building is the quiet assumption that someone smarter is already working on it, not a lack of skills or capital. Let me tell you, those 'smarter' people are usually not.
Many people spent a career in relative obscurity to deliver a breakthrough result in cancer care today. Hoping this drug gets to all the patients that need it as soon as possible/yesterday.
Declining kidney function is the most overlooked cause of death
Only 55,000 US deaths/yr are attributed to it, yet ~37M have chronic kidney disease & this speeds heart disease, infection, frailty & early death.
Markers to watch: Cystatin C & urine albumin
We have to remove the causes of death.
Remove the things that accelerate our aging.
And add the things that extend our healthspan.
We need to develop personalized nutrients tailored to each individual, helping protect the organs that age the fastest. For example, students may need extra support for their eyes, brain, and inactive muscles due to long hours of studying and sitting.
And this is possible to do.
That’s it.
Most people are dying from aging, cancer, accidents, metabolic disease and air pollution across many countries.
These problems need to be solved!
Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial
https://t.co/1Pll9b0d4q