David Sinclair

Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan

[David Sinclair @davidasinclair]

One shot and you’re protected from heart disease. Imagine that for cancer, dementia and aging

[Samuel Hume @DrSamuelBHume]

It feels very futuristic to imagine a world with one-and-done therapies that lower LDL cholesterol for life, but... it might not be far off!

These are new phase 1 data for Verve/Lilly's PCSK9 base editor: one single intravenous infusion reduces LDL cholesterol by as much as 60%

[David Sinclair @davidasinclair]

👏 👏 👏

[Lung Cancer Europe @LungCancerEu]

‼️ Landmark #lungcancer research published today in Cell

Scientists at the Francis Crick Institute and UCL have discovered a 14-protein blood signature that predicts lung cancer more than 5 years before diagnosis, works in never-smokers, and could identify who benefits from prevention treatment.

People with high levels of these proteins were the ones who actually benefited from a drug to damp that inflammation down, cutting their lung cancer risk nearly in half.

This could finally give us something lung cancer has never had: a way to prevent it in the people most at risk.

https://t.co/SaZwBHnxvZ

#LCSM

[Longevity Technology @LongevityTech]

The longevity biotech is accelerating toward the clinic after uncovering a promising age-reprogramming therapy years sooner than expected.

https://t.co/cG8VoDgwHg

#longevity #geroscience #biotech #cellularreprogramming #aging

@newlimit

[David Sinclair @davidasinclair]

The body responds to intensity more than duration.
Even ~4.4 minutes of vigorous daily movement associates with ~26–30% lower mortality risk

https://t.co/0RmbHKNDU2

[David Sinclair @davidasinclair]

Slowing aging is not theoretical. In humans, calorie restriction measurably slows biological aging pace by ~2–3% over 2 years
Link here: https://t.co/Eg8wBzhDpQ

[David Sinclair @davidasinclair]

Honored to be the Takeru Higuchi Lecturer of 2026. Previous speakers - Laureates Arthur Kornberg, Gertrude Elton, Aaron Ciechanover, and heroes of mine, Judah Folkman & Craig Venter

[David Sinclair @davidasinclair]

$3.1B! Congrats @brian_armstrong
Epigenetic restoration is sure heating up

[The Wall Street Journal @WSJ]

Exclusive: A longevity biotech co-founded by Coinbase’s CEO more than tripled in value to $3.1 billion—before its drugs begin human testing. https://t.co/g61a8OC1FE

[David Sinclair @davidasinclair]

$435M Series C. Congrats! 👏

[Brian Armstrong @brian_armstrong]

Aging is arguably the root cause of most major diseases (loss of function in our cells). Four years ago, we made a bet that aging was treatable, and NewLimit was born.

NewLimit now has a prototype drug that reverses the age of some human cells (restores function they had when they were younger), and a clinical trial scheduled for next year (with more drug candidates in the pipeline).

Grateful to Founders Fund, Thrive, Greenoaks, and the rest of the investors for this latest round. @jacobkimmel and the team are just getting started.

[David Sinclair @davidasinclair]

💯 Go for it!

[Peter H. Diamandis, MD @PeterDiamandis]

The reason most people never start building is the quiet assumption that someone smarter is already working on it, not a lack of skills or capital. Let me tell you, those 'smarter' people are usually not.

[Thomas Dayspring @Drlipid]

Amen

[David Sinclair @davidasinclair]

This is huge

[Blake Byers @byersblake]

Many people spent a career in relative obscurity to deliver a breakthrough result in cancer care today. Hoping this drug gets to all the patients that need it as soon as possible/yesterday.

[David Sinclair @davidasinclair]

Wearables need a setting called “lie to me”

[Nicholas Fabiano, MD @NTFabiano]

Believing you slept well can boost your cognitive performance even after a bad night.

Mind over matter.

[David Sinclair @davidasinclair]

@johnhemming4mp @biogerontology What is the correct science?

[David Sinclair @davidasinclair]

Interesting analysis of the main players in the space. One mistake - I don’t have a supplement company

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

Who runs longevity in 2026? Unfiltered published their top 100 list. Here is the digest with my comments

https://t.co/a0hFUmaHZ8

[David Sinclair @davidasinclair]

Loss of kidney function is not even mentioned

[David Sinclair @davidasinclair]

Cystatin C is one of the better routine blood biomarkers for predicting longevity

[Lifespan @JoinLifespan]

Declining kidney function is the most overlooked cause of death

Only 55,000 US deaths/yr are attributed to it, yet ~37M have chronic kidney disease & this speeds heart disease, infection, frailty & early death.

Markers to watch: Cystatin C & urine albumin

[SciTech Era @SciTechera]

We have to remove the causes of death.
Remove the things that accelerate our aging.
And add the things that extend our healthspan.

We need to develop personalized nutrients tailored to each individual, helping protect the organs that age the fastest. For example, students may need extra support for their eyes, brain, and inactive muscles due to long hours of studying and sitting.

And this is possible to do.
That’s it.

Most people are dying from aging, cancer, accidents, metabolic disease and air pollution across many countries.

These problems need to be solved!

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trial

https://t.co/1Pll9b0d4q

[David Sinclair @davidasinclair]

🙋🏻‍♂️
1. Playing vinyl records
2. Planting trees
3. Studying the epigenome

Can’t beat analog for richness

[Reads with Ravi @readswithravi]

Who still loves reading physical books?

[Maarten Boudry @mboudry]

Amazing graph. One the best visualizations of human progress.

[David Sinclair @davidasinclair]

Never said we can beat death. But we can definitely beat diseases

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

Nice article featuring @davidasinclair
📈🚀https://t.co/6vRVE0kOle