Dec Manning

I’m a postdoc at UC Davis researching mechanisms of blood flow control in the brain and heart

[Manuel F. Navedo @mf_navedo]

New pre-print from the M&M Lab! 🫀🔬

Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle that may influence vascular reactivity and physiology.

Check it out!

https://t.co/gWehBqSBit

[Geoanna Marie Bautista, MD @GeoannaBautista]

Out today in J Physiol: Piezo1 in intestinal smooth muscle doesn't only sense force at the cell surface. First paper built entirely at UC Davis across the causeway with trainees from several labs. This is the foundation my lab is building from!
https://t.co/uZ64FSenZm

[L. Fernando Santana 🇵🇷 @lfsantana68]

Editorial on our JACC-EP paper (https://t.co/UZ2AtgAWee) is out: Ed Lakatta’s “Mind Your ‘A Game’” (https://t.co/J6jcsDUfxg) spotlights SAN capillary rarefaction → slower rate + more beat-to-beat variability, and lays out next tests (hypoxia vs demand; aging/sex). @JACCJournals

[Dec Manning @DecManning94]

This is an important concept, and not just in the heart. Microvascular supply is crucial and can get disrupted in all tissues, in many ways. We want to understand why it happens, how, and most importantly... how can it be prevented?
(5/5)

[Dec Manning @DecManning94]

Our latest paper is out! @JACCJournals @ucd_physiology

https://t.co/4udQnH0SUq

We've shown that microvessels are lost in one specific region of the SA node in a model of early heart failure. (1/5)

[Dec Manning @DecManning94]

The fact that these events occur so easily (28-day low-dose AngII infusion) says volumes about the delicate metabolic balance our vital organs maintain to function. We're living on the edge!
(4/5)

[Dec Manning @DecManning94]

@notoriousDRG7 Congrats Cyrrus!

[Harry Pritchard @HAT_Pritchard]

Are you interested in discovering how blood flow to the brain is controlled and how it goes wrong in dementia? We have a MRC DTP project with @adamsgreenstein @stu_art_here & Ingo Schiessl, using state-of-the-art methods and models. Please share https://t.co/1P0cCc7NaG

[Harry Pritchard @HAT_Pritchard]

Our study into the mechanism behind the reduced blood flow in dementia has been short listed for research story of the year! We would appreciate your vote in the link below

[Dec Manning @DecManning94]

This review with @lfsantana68 and Ernesto Rivera focuses on what we know about capillaries as they grow, reach functional maturity, and degenerate in a range of diseases.

[Dec Manning @DecManning94]

Explore the mechanisms controlling microvessel growth, function and death in our latest review!

“The life cycle of a capillary: Mechanisms of angiogenesis and rarefaction in microvascular physiology and pathologies”

https://t.co/IVDuU8UhTg

[Collin Matsumoto @CollinMatsumoto]

Excited to share my newest work https://t.co/gE8a5PH41T with the Santana Lab (@lfsantana68) published in @CommsBio! Here we explore the unique sex-specific role Kv2.1 channel clustering plays in promoting Cav1.2 channel clustering and activity.

[L. Fernando Santana 🇵🇷 @lfsantana68]

Congrats, @DEOlsonLab and @LinTianPhD! @UCDBMM

[Dec Manning @DecManning94]

...and here it is! An exciting unveiling for Chisel-1, a functionalized nanobody which drives inhibition and internalization of CaVbeta1-associated calcium channels.

https://t.co/S1wmm1QFtK

[Dec Manning @DecManning94]

@lfsantana68 and I wrote a commentary for @NatureComms celebrating the latest work from the Colecraft group with @ElectrosomeUCSF @NehaNirwan23 & others

Selective inhibition of CaVbeta1-associated channels with a functionalized nanobody – powerful stuff!

https://t.co/ikXu0f8jKi

[Dec Manning @DecManning94]

@DrContrexin @mfco5m @ucd_physiology @AHA_Research Congrats @mfco5m!

[Dec Manning @DecManning94]

@Miguel_MartinAB @mf_navedo @MNCline @VicTamez88 @Rebound_32 @raghureddy92 @_abbyburns Congrats! Great work!

[Dec Manning @DecManning94]

I have published a review!

My doctoral work focused on store-operated channels and the numerous ways they control skin function.

Watch this space for data from my PhD @LivUniISMIB and new publications from my work with @lfsantana68 at @ucd_physiology.

https://t.co/unh1ahneHr