Denise Sheer

Professor of Human Genetics, Queen Mary University of London/ Barts & The London ~ Brain Tumours, Neuroscience, Genetics, Epigenetics, Molecular Biology

[Barts Charity @Barts_Charity]

Yesterday, we were visited by Professor Cleo Bishop, who told us all about her incredible research into new treatments for basal-like breast cancer - an aggressive molecular subtype of cancer.

Breast cancer is now the most common cancer in the world, and kills one person every 45 minutes.

With our funding, @CleoBishopLab has identified a weakness in these tumours, and is exploring methods to both stop tumour growth and then kill the cancerous cells.

More about Cleo's work here: https://t.co/fT9Hs80ku7

#breastcancerawarenessmonth #bcam 🎀 @blizard_inst

[nature @Nature]

Nature research paper: Cellular adaptation to cancer therapy along a resistance continuum https://t.co/K2ye3wNEXi

[Professor Georgina Long AO (Bluesky @gvlongphdmd) @ProfGLongMIA]

Important results for #melanoma. Proud of the work with international colleagues, @MelanomaAus & patients and their families - the longest follow up of any of the trials testing now standard drug therapies that save lives. Results impactful - esp for those with V600E #BRAF mutation positive melanoma. Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma | New England Journal of Medicine https://t.co/CNdClQdXDN

[Nature Portfolio @NaturePortfolio]

Data from a trial reported in @NatureMedicine show that precision-guided treatment informed by comprehensive molecular profiling significantly improves outcomes for children with high-risk cancers. https://t.co/932hOzbeDu

[Pradeepa Madapura @PradeepMadapura]

Fascinating findings showing histone acetylation is not a consequence of transcription https://t.co/vd4Vzh7lgs

[The Brain Tumour Charity @BrainTumourOrg]

Today is #WorldBrainTumourDay! Did you know that 72% of people in the UK can’t name a brain tumour symptom? Use our symptom checker today and make sure you #KnowTheSigns: https://t.co/s1pBcywEyJ

#BetterSafeThanTumour

[National Cancer Institute @theNCI]

The @FDA has granted an accelerated approval to tovorafenib (Ojemda) for kids and teens who have low-grade glioma with changes in the BRAF gene. In a small clinical trial, the drug shrank or completely eliminated tumors in nearly 70% of patients. https://t.co/m9B3lA4wEn #BRAF

[Benedict Diederich @beniroquai]

Finally, it's "officially" out! Very nice work by Ando et al.. The review process really boosted the quality of this method. Super-resolution microscopy for everyone! @eLife: https://t.co/hcMn49SNvP and building instructions: https://t.co/iNEhBvAqRf @ewers_helge

[Miguel Branco @BrancoLab]

We have two new faculty opportunities at QMUL, part of a £3.2M investment by @Barts_Charity to develop genomic and epigenomic liquid biopsy analyses for diagnostics and research applications.
More details here: https://t.co/TBlDEp1sF0
Please RT abundantly

[Karine Begnini @KarineBegnini]

Very happy to share that our new study is out at @J_Cell_Sci ! In this work we discussed the contribution of asymmetric mitosis to cancer heterogeneity. Check it out at https://t.co/OvxY0ueNHc

@LabSinal
@gulenz
@julietihbuss

[Adrian Biddle @DrABiddle]

When we have access to advanced human pathology and clinical data, and fantastic new in vitro models that are predictive of human disease, then we have to ask the question - who needs mice? 🐁 🧵

[Dr Andrew Meyerson @AndrewMeyerson]

Dear 🇬🇧,

The usual suspects are at it again, trying to convince you that the NHS — which they destroyed — isn’t fit for purpose and that you need a new healthcare system. They’re dead wrong. Here’s how to challenge them.

#SOSNHS

[@qmulepigenetics @QMULepigenetics]

Please join us for the @QMULepigenetics seminar by @kristian from @icr_london 11th Jan. 15.30GMT. venue: Derek Willoughby Lecture Theatre, at our Charterhouse Square campus and online link at https://t.co/CbmwrgU7Fe

[Karim Brohi @karimbrohi]

A massive day for UK trauma with the publication in @JAMA_current of two game-changing trauma trials: @CRYOSTAT_2 and @UKREBOATrial.
Both turning points in how we understand and treat trauma patients.

UK-REBOA: https://t.co/PLEs7LXZ5o
CRYOSTAT-2:
https://t.co/U9Yv0857JO

[Barts and The London, Queen Mary @QMULBartsTheLon]

Research from Queen Mary, funded by @BartsBRC and @Barts_Charity, gives new insight into blood clot risk for women. Read more: https://t.co/m6IogJvAJj

[Sarah Finer @Sarah_Finer]

Our latest @EastLondonGenes preprint explores diabetes misclassification in British Bangladeshis and Pakistanis. Fabulous work from @TimingLiu, Alagu Sankareswaran and Gordon Paterson. With great colleagues @hilsomartin, Giriraj Chandak, @YajnikYa9 @RAOram.

[Gideon Burrows - east london renewed @gideonburrows]

The audio version of my best seller on glioblastoma and anaplastic astrocytoma, Glioblastoma: A Guide for Patients and Loved Ones is now available. I hope to reach an audience that might not otherwise have been able to read or access this important book. https://t.co/jzkuuDtgZN

[Tom Milne @milnetom68]

It is fantastic to finally be able to see this paper in print, great collaboration with everyone:

https://t.co/8uYefyX6gf

MLL-AF4 creates high density enhancer interactions by recruiting a transcription complex including FACT and PAF

[Matthew Geleta @MatthewGeleta]

Thanks @fjmubeen for joining me on the Paradigm podcast to talk about #ArtificialIntelligence and education, and shout out to the legendary @SLSingh and @brilliantorg for inspiring much of this conversation. Enjoy! https://t.co/qJvWAJIiMi

[Robert Seaborne @RobbySeaborne]

New preprint. Excellent work by a big collaborative team!

Ribosomal DNA copy number is associated with body mass in humans and other mammals | bioRxiv https://t.co/w6Qzjt0dga