Sebastian Schäfer

VVB Bio

[Sebastian Schäfer @DerSeb81]

@MartinBJensen @Boehringer We have designed a new antibody with an ageing therapy in mind at VVB Bio: https://t.co/ik7HMFoc6L

[Sebastian Schäfer @DerSeb81]

@MartinBJensen @Boehringer 😀 https://t.co/ik7HMFoc6L

[Sebastian Schäfer @DerSeb81]

@davidasinclair We hope to find out, with our antibody designed for an ageing therapy: https://t.co/ik7HMFoc6L

[Lasker Foundation @LaskerFDN]

Translated small open reading frames (smORFS) have been difficult to identify in the genome, though it is known they can play important regulatory functions. Now, scientists publish a high-resolution atlas of translated smORFs in human cells. @OwenRackham https://t.co/1IxmTn0gwt

[EleonoraA @Ele_Adami]

A long and winding road (cit🎶) led us here and this would not have been feasible without a great team behind it! I'd like to thank all the people involved and especially @SoniaChothani @OwenRackham @DerSeb81 @aa_widjaja @stuartacook1
Here the link again: https://t.co/qYeWz1CfKf

[EleonoraA @Ele_Adami]

...And it's out @MolecularCell! 🥂
We, the team, are happy to share with the field an atlas of 7k small ORFs (smORFs) detected in 11 human tissues/ primary cells.
https://t.co/qYeWz1CfKf

[Molecular Cell @MolecularCell]

Online Now: A high-resolution map of human RNA translation https://t.co/KuOJgaHzBE

[Owen Rackham @OwenRackham]

Here is our high-resolution map of human translation https://t.co/w1cvEkysbp. This paper has been six years in the making - we hope it will be helpful to the many groups studying smORFs and even those that aren’t but should be! There are some features that I want to highlight:

[Stuart Cook @stuartacook1]

64 patients with Covid

Patients divided into two groups: those <60 years (n=33; COVID-under “CUN”; green) and those > 70 years (n=31; COVID-over “COV”, blue)

Anti-IL6R (tocilizumab) saves lives in severe covid

Time to try anti-IL11 as well?

[Stuart Cook @stuartacook1]

Renal failure in Alport syndrome

Anti-IL11 therapy + ACEi in mouse model of Alport doubles lifespan

Podocytes + epithelium protected, EMT + fibrosis inhibited: better kidney function

Amazing study by the talented Anissa Widjaja

⁦@AlportSyndFndn⁩ https://t.co/ToCKbaFmeH

[Stuart Cook @stuartacook1]

Anti-IL11 reduces aortopathy in the mouse model that led to the use of ACEi in patients with Marfan syndrome

MFS = TGFB overactivity = IL11 up-regulation and disease

Congrats to WW for 5 years of hard graft!

⁦@MarfanTrust⁩ ⁦@MarfanFdn⁩ https://t.co/RLihPAEy72

[Stuart Cook @stuartacook1]

European Patent Office just published that the most recent attack on one of our fibrosis patents is rejected

This is the third opposition in 2 years

Bayer this time...

Don't let VC/Pharma tell you university patents don't matter

They do

BTW going to court = scary 😬

[Stuart Cook @stuartacook1]

Happy/not happy the head of Genentech research thinks

“IL-11 signaling by fibroblasts is a conserved molecular circuit that may be shared among diverse inflammatory fibrotic diseases and therefore represents a potential therapeutic target to prevent fibrosis."

PMID: 35085231

[Sebastian Schäfer @DerSeb81]

@iamcryptonanda @100trillionUSD His claims that hydroxychloroquine treatment works are false. Several large studies show hydroxy treatment has no effect, e.g.: https://t.co/6l89WAgzrd

Other drugs that work were found and are being used: https://t.co/FVi7gHwlQx

Our medical professionals are doing their best.

[Stuart Cook @stuartacook1]

Old adage, "crap cells, crap data" - ever true

Its hard to examine the effect of a ligand on a cell if the cell doesn't express the ligand's receptor...

36 pages of protocols on how to use primary cells to study IL11 signalling DOI: 10.1002/cpz1.251

[Stuart Cook @stuartacook1]

IL6 tans signaling

The foundations underpinning the last few decades of research look shaky

How this plays out will be interesting

All is not as it seems….

😮 https://t.co/KRHLh6m6uU

[Sebastian Schäfer @DerSeb81]

@stuartacook1 Haha, once in a lifetime 😎

[Stuart Cook @stuartacook1]

Guys - stop it, go on now...its all too much....

Another day, another Editorial decision...@DerSeb81

Coming out soon: "Critical conditions for studying Interleukin-11 signalling in vitro and avoiding experimental artefacts"

😃

[Sebastian Schäfer @DerSeb81]

@Ele_Adami @ImmunityCP 🤔

[Stuart Cook @stuartacook1]

This manuscript explains why IL11 is so terribly misunderstood

Published on ⁦@biorxivpreprint⁩ 18 months ago, downloaded >1000. Published now in STM [message unchanged]

Fabulous Singapore team led out by the talented ⁦@aa_widjaja⁩ https://t.co/PUNtLPKyk6