Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human development! https://t.co/zIUjPy6ZLz. Read on for more 🧵 [1/16]
📢 New KFW Lab paper out now in @ScienceAdvances! 📢
We show that AML cells resist chemotherapy by reversing the ATP synthase reaction—supporting oxidative metabolism and maintaining mitochondrial membrane potential. 🔬🧬
👉 https://t.co/ChVcsRnXzM
A single molecule provides a controllable connection between a normal metal and a superconductor
Letter: https://t.co/ov1M8MmdOI
Focus: https://t.co/W3kapywhiL
T cell-derived interleukin-9 potentiates differentiation of GC memory precursors into functional memory B cells in a manner dependent on the transcriptional regulator ZBTB18 @ImmunityCP
https://t.co/4AWE8Qeo1l on
https://t.co/wVsY7V6m5L
🥳🔥Our study is out in @GenomeBiology! Conventional filtering out high-mtRNA cells depletes key malignant populations in cancer single-cell studies. Read it here 👉 https://t.co/vHGdsnUZP9 Thanks to the dream team: @JoYatesResearch@KraftAgnieszka
New paper from our group in @Nature by @YiyunLin_YL@junkewang@KaileWang and team reporting the unexpected discovery of aneuploid epithelial cells (3%) in normal breast tissues from healthy women raising the question of when is cancer really cancer?
https://t.co/uLig55dK0u
In a phase 1 trial, patients with AML treated with CD123 CAR T therapy experienced high levels of cytokine release syndrome and short lived clinical responses, likely due to CAR T-derived cytokines increasing viability of blasts. https://t.co/XsmzsHuyJx
BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Why do AML patients with African ancestry have poor outcomes? Fascinating results indicate that genetics alter AML biology. Also, its Bailee Kain's first co-first author postdoc pub. @Bailee_Kain@AkEisfeld@nsalomonis and Elaine Mardis
https://t.co/jG0z4sWaNT
Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10
@PennMedicine@CHOP_Research@GillSaar https://t.co/Dkp8YsSYJ9
Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. https://t.co/ZTFNZkwpcj