Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem
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1/ 🚨 New Paper Alert! Our latest research in bioRxiv uncovers how translation inhibitors kasugamycin, edeine, and GE81112 target different steps in bacterial translation initiation, offering high-resolution insights into their mechanisms. 🧬🔬 #StructuralBiology#CryoEM
Our results finally explain the essential role of snR30 snoRNA! Check out the details in our preprint to find out more 👉👉👉 https://t.co/UJ8ib8Miw0
#ribosome#cryoEM#RNA
Our collaboration with @WilsonLab2 and @vpelech is out in @NAR_Open! The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site
https://t.co/CwtkuGEjB8
Excited to be elected as @RNASociety Director! Congrats to co-elected Directors @AndrzejDziembo1 and @BeAScientist, and President-Elect Fatima @GebauerLab!
Finally, out!
MFSD1 functions as a general dipeptide uniporter in lysosomes!
This was a real team effort. Many thanks to @Kathaschnatta, @DammeMarkus, @OceaneGuelle and Bruno Gasnier, @AhmadRezaMehdi1, @abu_remaileh, and everyone else involved!
See: https://t.co/ltklnR3Rp6
Our latest submission to @biorxivpreprint is now available online:
https://t.co/mmB6stIgjV
A joint effort between Harpreet, Jutta, and Asen, and our previous rotation students Eric, Christian, David, Katalin, Daniel, and Felix @UniHeidelberg@biorxiv_biochem@dfg_public
Out in @NAR_Open! A transcontinental consortium involving @WilsonLab2@gem__atkinson and other ribosomal aficionados establishes YlmH as a new ribosome-associated quality control (RQC) factor in Bacillus subtilis! https://t.co/5vpugO7QQO
Out in @NAR_Open! A transcontinental consortium involving @WilsonLab2@gem__atkinson and other ribosomal aficionados establishes YlmH as a new ribosome-associated quality control (RQC) factor in Bacillus subtilis! https://t.co/5vpugO7QQO
Together with @WilsonLab2 and @pelechanolab we show that yeast ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site.
https://t.co/zkS9mAGWrI
Our preprint reporting the structure and mechanism of the natural product translation inhibitors paenilamicins is out…completely novel binding site on the ribosome! https://t.co/wCoi8Safjc…great collaboration with @Suessmuth_Lab @shuramankin
Special credit to first authors @TimmKoller and Max Berger. Also thanks to @shuramankin for hosting Max in Chicago to complete some experiments for this project and to Bertrand Beckert from @DCI_EM for great cryoEM data as always.
bioRxiv: Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis https://t.co/9V3x5GeSAQ
Cool stuff from the Plaschka lab (@plaschka_lab). Finally some mechanistic insight into the connection between the TREX and the TREX-2 complex. Bravo! https://t.co/DY1eXKi5kW