Kartik Angara

MSL with @carisls | #PrecisionMedicine for #Neurooncology #braintumors #gliomas | #Psychiatry, #consciousness, #metaphysics & #astrophysics enthusiast | INFJ

[Kartik Angara @Doctor_StrangeK]

Lots of fascinating #PrecisionMedicine discussions at @carisls booth today! #sno2022 has been great so far! Comprehensive #tumorprofiling is the way to go! Let’s support this fight to end #braintumor!

[Anna Ciaunica PhD @annaciaunica.bsky.social @AnnaCiaunica]

What can depersonalisation disorder say about the self? | Aeon Essays https://t.co/0hhsMYxnub

[Kartik Angara @Doctor_StrangeK]

@IlonLiu @MatsNilssonLab @FilbinMariella @NatureGenet Elegantly detailed and comprehensive! Great work!

[Ilon Liu @IlonLiu]

1/How do age and anatomical location shape H3-K27M gliomas' intrinsic and extrinsic features❓Very excited to share this work together with Li Jiang, Erik Samuelsson, @MatsNilssonLab and @FilbinMariella , published today @NatureGenet❗️https://t.co/pMVsUYFpb1

[Dileep George @dileeplearning]

You know English. You don’t know Malayalam. You decide to learn it by listening to podcasts that are purely in Malayalam. What will happen?

A thread about language models, meaning, understanding etc…. Plus, you get to learn Malayalam :-) 1/N

[Jonathan Shedler @JonathanShedler]

1/ People often ask what readings I recommend for clinicians & trainees who want to learn about psychodynamic therapy. Here's a partial list

For a bird's eye, jargon-free introduction to psychodynamic thought, read chapters 1 and 2 of "That Was Then, This is Now" by yours truly.

[Matthew Schrag @schrag_matthew]

My thoughts on the phase 3 results of Alzheimer's drug lecanemab from Biogen and Eisai, presented at #CTAD #CTAD22 and published this evening in the @NEJM. Major takeaway – this is NOT the breakthrough we have been waiting for. Key points:

[Stephen Yip, MD/PhD FRCPC @Sty_md]

Myxopapillary ependymoma from the thoracic spine... the reason why it is a CNS WHO 2 tumour in CNS5. Despite the low-grade histology, some do recur locally and along the neuraxis. One of my case "metastasized" to the temporal lobe and bled out

[Cancer Cell @Cancer_Cell]

Online Now: Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors https://t.co/QpgQtUlx8R

[Stephen Yip, MD/PhD FRCPC @Sty_md]

Papillary #meningioma (CNS WHO 3) with BAP1 loss by immunohistochemistry. 7/8 of cases signed out as rhabdoid meningioma turned out to be BAP1 retained. Molecular biomarkers are needed to overcome variance in histological interpretation.

[Brigham and Women's Pathology @BWHPath]

A patient presented w/an ill-defined FLAIR hyperintensity/T1 hypointensity in the temporal lobe on MRI and new onset partial seizures. The lesion was resected through a craniotomy. What is your differential dx? #BWHPathCotW #BWHNeuroPathWinter #PathTwitter #Neuropathology

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[Brigham and Women's Pathology @BWHPath]

Case contributed by: Dr. Andres Santos (@SantosMDPHD), and Dr. Keith L. Ligon (@KeithLigon5). @BWHNeuropath

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[My Neuropath News @NeuropathClinic]

The genetic and phenotypic spectra of adult genetic leukoencephalopathies in a cohort of 309 patients #neuropath
https://t.co/QNbzXGC430

[My Neuropath News @NeuropathClinic]

Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology #neuropath
https://t.co/SgWrLlLuuN

[NatureRevClinOncol @NatRevClinOncol]

In the phase III externally controlled trial of autologous tumour lysate-loaded DC vaccination (DCVax-L) vs SoC for newly diagnosed or recurrent glioblastoma demonstrates promising median OS durations & meaningful increases in the tails of the OS curves: https://t.co/hJwfoQ6H0I

[Cory Muscara @corymuscara]

I meditated 15 hours a day for 6 months straight with one of the toughest Buddhist monks on the planet.

Here's what I learned:

[Brain Pathology @brainpathol]

Clinical implementation of integrated molecular-morphologic risk prediction for #meningioma
WHO grade + methylation class + 1p/6q/14q CNV
@DKFZ #neuropath
Is there a need for TERT and CDKN2A? Read more:
https://t.co/xLIBnInOiz

[Kartik Angara @Doctor_StrangeK]

One of the best sessions from the Neuro-oncology review course this year at #sno2022 by Dr. @MalinzakMichael! Neuro-radiology made engaging and palatable to non-clinical audiences as well!

[Roel Verhaak @roelverhaak]

DYK that GLASS data is accessible through the cBio portal? https://t.co/Se4H7SsBAJ

[Alex Wyatt @ResearchWyatt]

I'm seeing some conflation of terminology around HRR-related gene mutations and the HRD phenotype in prostate cancer. Here's a slide I use to clarify. It matters because several HRR-related gene alterations (e.g. within ATM) do not appear to result in an HRD mutational signature.