Our paper from the Pulmonary Hypertension team at Royal Brompton @RBandH in @ESC_Journals - Survival outcomes in EIF2AK4 mutation-associated pulmonary arterial hypertension: seeking clarity in contrast https://t.co/gN5v70Awvo
Slow night for med reg jobs so decided to attach myself to the F1 on ward cover.
Surprisingly fun fielding F1 jobs again. Like going back to a Level 10 area when you're Level 60 and just one-shotting everything that used to cause you so much grief.
This is absolutely wild. Rubbing in a dye (found in Doritos) to make skin transiently transparent. Non-invasive and reversible = huge implications for diagnostics ! @ScienceMagazine
Great summary piece here by one of the authors: https://t.co/jolmrHtdnP
By topically applying a common food dye that strongly absorbs light to a live mouse, researchers were able to turn its tissues transparent, allowing them a look into the blood vessels of the scalp, the movement of organs laying under the skin of the abdomen, and tiny contractile units of muscle at work.
Learn more in the new research out in Science: https://t.co/UEECckWlwX @NSF
Trial after trial, and with safer stent platforms, dual antiplatelet therapy (DAPT) durations are decreasing. But are we ready to eliminate DAPT entirely? We wrote this viewpoint to summarize the evolutionary journey of trials on aspirin-free strategies after percutaneous coronary intervention. https://t.co/vwO3dLSXsb
https://t.co/BXwtL1sc8w
New class of antibiotic - Zosurabalpin defeated highly drug-resistant strains of Carbapenem-resistant Acinetobacter baumannii (Crab) in mouse models of pneumonia and sepsis, and was being tested in human trials.
@Nature
Merry Christmas to all those working in the NHS today
Many staff in the NHS are grossly underpaid (even on Christmas day👇) but none more so than Junior Doctors who frequently graduate with >£100k debt
RT to support them & ask government to pay them ALL fairly #PayRestoration
A simple nudge such as placing a chair at a patient’s bedside can increase a physician’s likelihood to sit by 20-fold, finds study, which also improves patients’ perceptions of their physician 👍🏽
Study includes a #VisualAbstract#BMJChristmas
https://t.co/l4SRteRFbQ
Just starting training in Cardiology?
Or just curious about echocardiography?
Free online echo course for absolute beginners - all welcome!
https://t.co/pHA4qwewXF
Anticoagulation for atrial fibrillation in patients with intermediate stroke risk: is the grey zone becoming less grey? Reaf more in EHJ.
https://t.co/rxCVUwXC7y
#AF
A single subcutaneous injection of lepodisiran substantially lowered Lp(a) for 48 weeks,based on results from a first in-human study presented at #AHA23. Findings hold promise for treating previously untreatable disorder, says Dr. Steve Nissen. https://t.co/TvQJlCq2JZ
ORBITA-2, the revenge. In a randomized, placebo-controlled trial of 301 patients with stable angina who stopped all antianginal medications and had evidence of ischemia, the mean angina symptoms score at 12 weeks was lower with PCI than placebo. https://t.co/9iEQMlkVjq
Both #TAVR and SAVR appear to be valid alternatives for treating patients with severe #cvAS and small aortic annulus, based on findings from VIVA presented at #TCT2023. Larger RCTs are needed to confirm results https://t.co/Xmcb5xtazZ
@ESICM#LIVES2023 Late Break Clinical Trials in @NEJM@JAMA_current
4. 3 days inhaled amikacin prevents ventilator associated pneumonia in pts after 3 days invasive mechanical ventilation
5. Convalescent plasma reduces mortality in COVID19 ARDS mechanically ventilated pts
In this trial of simvastatin involving critically ill pts with Covid-19, which was stopped owing to reduced cases, simvastatin did not meet the prespecified criteria for superiority to control treatment.
Full REMAP-CAP trial results: https://t.co/Rh3hSBhM6S @ESICM#LIVES2023
#ESICM Late Break Clinical Trials in @NEJM@JAMA_current
1. Simvastatin probably helps in critically ill COVID19 patients
2. IV Vit C not helpful in COVID19 & may be harmful
3. Lanidolol doesn't help in septic shock pt with organ failure supported on norad & may cause harm