Melissa Eccles

BioMed PhD Alzheimer's disease mechanisms, she/her, views are my own, @CurtinUni @CHIRI_curtin @DementiaAus

[Melissa Eccles @EcclesMelissa]

A very nice end to my PhD @CHIRI_curtin @CurtinUni with the first paper from my PhD published in @FASEBorg

[AD Mechanisms Laboratory @AdMechanisms]

🚨 @EcclesMelissa has rounded out 2023 with her 🥇first-author paper @FASEBorg “Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase”
@NathanMain16
@rodcarlessi
@ayeisha_m_a
@NinaTParker
@AusDementiaEMCR

https://t.co/c1XJOf1NTE

[AD Mechanisms Laboratory @AdMechanisms]

🚨 @EcclesMelissa has rounded out 2023 with her 🥇first-author paper @FASEBorg “Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase”
@NathanMain16
@rodcarlessi
@ayeisha_m_a
@NinaTParker
@AusDementiaEMCR

https://t.co/c1XJOf1NTE

[AD Mechanisms Laboratory @AdMechanisms]

It’s been a big year for our PhD student @EcclesMelissa 🙌🏽⭐️ On Friday she took out the 2023 Student Prize at the @CurtinUni Curtinnovation Awards for the project “MacroMop” alongside @BenjaminDwyer4 🧫🔬Check it out below ⬇️

https://t.co/Qov88iNH1g

[AD Mechanisms Laboratory @AdMechanisms]

🚨 Proud lab ‼️@EcclesMelissa took on @BioRad #battleoftheblots and won Best Normalisation and Quantitative Blot with the judges identifying her entry as the "gold standard for quantitative blotting". Known @CHIRI_curtin for her blots we’re proud to see them on the world stage!!

[Melissa Eccles @EcclesMelissa]

The 2nd preprint from my PhD is now available!! Keep an eye out for a more to come over the next few months!!
I am now on the fast march to submission & actively looking for what comes next #postdoc
@AusDementiaEMCR @DementiaAus @CHIRI_curtin @CurtinUni
https://t.co/J5rokrpjrl

[Melissa Eccles @EcclesMelissa]

If you're interested in directly quantitating endogenous #PSEN1 & #PSEN2 proteins so you can account for expression as a factor of #gammasecretase activity or compare expression levels in different cell lines and tissues hit me up!! 4/4

[Melissa Eccles @EcclesMelissa]

Very pleased to see this piece of work out in the 🌏 we used new tools to directly quantiate endogenous #PSEN1 & #PSEN2 proteins 1/4
https://t.co/fW8aTYbz4i

[Melissa Eccles @EcclesMelissa]

We can now directly account for different #PSEN expression as a factor of #gammsec activity, and show that #PSEN2 is at least as active as #PSEN1 at processing #APP and #Notch

[Melissa Eccles @EcclesMelissa]

We can now directly account for different #PSEN expression as a factor of #gammsec activity, and show that #PSEN2 is at least as active as #PSEN1 at processing #APP and #Notch 3/4

[Melissa Eccles @EcclesMelissa]

We show that in HEK cells endogenous #PSEN1 protein is 5-times higher than #PSEN2, and this expression profiles is retained when exogenous #PSEN are expressed on double knock-out background

[The Australian Society for Medical Research (ASMR) @TheASMR1]

🗣📢 Calling all WA health + medical researchers + students!

The WA ASMR committee have some great events coming your way:

🧪Scientific Symposium, June 2 (great prizes to be won!) -Abstracts close May 10

💃Gala dinner, June 9 -RSVP May 31

DETAILS: https://t.co/SyBu6JZE1R
1/3

[Ayeisha Milligan Armstrong @ayeisha_m_a]

Finished up #ADPD2023 with a trip to Gothenburg’s archipelago, lucky us 🍀 🛥️ 🧠 @EcclesMelissa @TeniellePorter @shanemfernandez
#researchteam
#WArepresent
#dementiaEMCR
#womeninstemm

[Melissa Eccles @EcclesMelissa]

@SaraCarder3 @PhDVoice I found a couple of friends at the same writing up stage and we started a group chat, we try to check-in Monday for weekly goals, then daily in morning to set goals for the day & evening to see how we went. Additionally we help motivate each other through our motivation slumps.

[Melissa Eccles @EcclesMelissa]

@AckermansNicole I have just discovered Obsidian @obsdmd and it has changed my life, I wish I found this at the beginning of my PhD but alas better now than in another year or two...links notes, tags, great plugins, great community

[Ayeisha Milligan Armstrong @ayeisha_m_a]

Here’s to the end of 2022 🎉 Two lucky PhD students and their super🌟 supervisor #AcademicTwitter

[Melissa Eccles @EcclesMelissa]

Feels like a milestone type of day, finished my experiments, cleaned up my desk and now just a little more writing to do and this thing should be phinished!! #phdlife #PhD #ADResearch @AdMechanisms @CHIRI_curtin @CurtinUni

[AD Mechanisms Laboratory @AdMechanisms]

A big thank you to @TheresaKlemm for having us yesterday! 3 WA PhD students very inspired by @WEHI_research

@ayeisha_m_a
@EcclesMelissa
@AmyWoodfield1

[Melissa Eccles @EcclesMelissa]

Excited to share work from my PhD looking at the roles of #presenilins in #microglia here at #ANS2022

@AusNeuroSoc @AusDementiaEMCR @AdMechanisms @DementiaAus @CurtinUni @CHIRI_curtin

[The Australian Society for Medical Research (ASMR) @TheASMR1]

Many research-intensive countries including 🇬🇧🇺🇸🇵🇹🇦🇹🇩🇪🇫🇷🇪🇸🇮🇪🇸🇪 have significantly increased💰into #health & #medicalresearch in response to the pandemic
In🇦🇺 funding flatlined, success rates ↘️ & the workforce is demoralised… we are falling behind on the world stage #ausvotes22

[The Australian Society for Medical Research (ASMR) @TheASMR1]

We have had no meaningful increase in @NHMRC investment for over a decade. Outstanding science is going unfunded and we are losing world-leading scientists. We call on both sides of politics to support the sector & commit to doubling the @NHMRC budget #auspol #ausvotes2022