Nichlas M Engels

Harris Lab, University of Arizona Ph.D student.

B.S in Biology from UNC Chapel Hill

Previously a research tech in Giudice Lab-UNC

#S04 #GoHeels

[Caitlin Dougher, MS @CaitlinDoug]

I matched! Really excited to continue my training starting this July at LIJ/ZHH!! #APPIC

[MuscleX_Lab @MuscleX_Lab]

It was very nice to welcome our muscle users @HesselAnthony @mikuehn8 @vivekpjani back after two years for @advancedphoton upgrade. BioCAT remains the state-of-art facility for muscle X-ray diffraction.
Proposal for next run due in two days!

[Aurora Scientific @AuroraSci]

As #BPS2025 nears, we wanted to highlight a recent publication in biophysics! 🔬

@HesselAnthony et al. investigated the role of MyBP-C in muscle 💪contraction and regulation with small-angle X-ray diffraction and #AuroraScientific 1600A system.

https://t.co/tP8s3bRw0y

[Anthony Hessel, PhD @HesselAnthony]

Huge beamrun over at LiX beamline, NSLS II @BrookhavenLab. Last 96 hours with veterterans @EngelsNichlas / Rachel Sadler, Christine Delligatti @cdelligatti13, and the brilliant @KhoiD_Nguyen.

[Nichlas M Engels @EngelsNichlas]

@al_venuto @NSF @Christa_A_Baker Congrats Alex!! So excited to hear more about this as you continue on!

[Anthony Hessel, PhD @HesselAnthony]

@EngelsNichlas puts in the big effort at @advancedphoton @argonne and NSLSII @BrookhavenLab during monster data collection runs. Head down / stay positive. He w/ @sp_harris1 lab are uncovering the roll of MyBPC to the regulation of force production. Loads more projects incoming!

[Sakthivel Sadayappan, PhD, MBA @sadayappanlab]

@EngelsNichlas, We are excited to see your presentation! You are making #MyBPC famous!
@UArizonaCMM @UAZHeart @UAZHealth @UAZBIO5

[Anthony Hessel, PhD @HesselAnthony]

Day 12, 230am. It is Finished! We are out of samples! The monster beamline run is over! What a ride! So many things accomplished over 2 continents and beamlines. Mouse hearts, human hearts, various skeletal muscles, cardiac strips, zebra fish, MARP proteins...214 hours of work.

[Anthony Hessel, PhD @HesselAnthony]

Day 10/11. Heavy lifting back at NSLSII at BNL. Some hiccups on the way: RIP special ABs at Newark customs. But lots of success on several other projects! @KhoiD_Nguyen, @EngelsNichlas, Rachel Sadler, and Brad Palmer Crew working at max capacity! Final 40 hour push starts now.

[Anthony Hessel, PhD @HesselAnthony]

And we are three days in! So many pappilary muscles. Progress ok! Now a quick shower, pack a bag, prep a few more samples, and then straight to the plane for the Hamburg run at @desy! See you soon @mikuehn8!

[Anthony Hessel, PhD @HesselAnthony]

T-0.5 days until our Xray beamrun. Build day! Long day of vpreparing. Tomorrow is showtime!

[Illinois Tech Lewis College of Science and Letters @IITSci_Letters]

Assistant Professor Weikang Ma pushes the boundaries of science, searching for ways to protect the heart against inherited cardiac diseases. Having received a $2 million grant from @NIH, Ma’s research is on the path to a new frontier.
Discover Ma's impact:https://t.co/KHYCZUuA0e

[Muscle Cell News @musclecellnews]

Researchers led by Dr. @HesselAnthony reported that fast myosin binding protein C knockout in #SkeletalMuscle 💪 alters length-dependent activation and myofilament structure.

📍 @CommsBio | https://t.co/SWLiO1PYfG

[MuscleX_Lab @MuscleX_Lab]

This is how great science is made, by 75% Chinese rockets fuel @HesselAnthony @mikuehn8 @EngelsNichlas @vivekpjani

[Aric Toler @AricToler]

This bike lock is/was available for sale on campus via Columbia's Public Safety department under their "Crime Prevention Discount Bike, Locker and Laptop Lock Program".

See their flier with a discount here: https://t.co/cXudPIG70k

[Samantha Harris @sp_harris1]

Great visit with @HesselAnthony! Such a great scientist and colleague!

[Anthony Hessel, PhD @HesselAnthony]

@musclecellnews @EngelsNichlas @sp_harris1 Also @mikuehn8 and Dr. Weikang Ma at the BioCAT beamline, @advancedphoton @argonne

[Muscle Cell News @musclecellnews]

Scientists including Drs. @HesselAnthony, @EngelsNichlas, & @sp_harris1 reported that myosin-binding protein C regulates the #sarcomere lattice and stabilizes the OFF states of #myosin heads.

👉 https://t.co/4Et1BuQVvm

[Anthony Hessel, PhD @HesselAnthony]

Just wrapping up an amazing few days with the @sp_harris1 lab! A little celebration of our new Nat Comm paper but already scheming for the bombshell follow-up paper being prepared by @EngelsNichlas. See you all at the myofilament meeting!

[Nichlas M Engels @EngelsNichlas]

So excited to share this work is now published in @NatureComms. It was great to work with @HesselAnthony throughout the process, and I look forward to sharing MyBP-C cleavage structural changes in active skeletal muscle in the next one!

[Anthony Hessel, PhD @HesselAnthony]

Really excited to announce our work using controlled MyBP-C cleavage in skeletal muscle is now published open access in @NatureComms! @sp_harris1 and I agreed to this collab in September 2022 and now complete! Ask any Qs in the comments! 👨‍🔬👩‍🔬🔬💪

https://t.co/5TcwHF3fP2