Excited to share our new work on transgenerational adaptation https://t.co/nppbqo9zpw out today spearheaded by outstanding former undergraduate Kathleen Kim NOT C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content,+ longevity 1/9
Axolotls use adrenaline signaling to regenerate legs! Today, we can finally share the official publication of a really exciting project we've pursued over the last several years. Thanks to the entire team for their creativity, expertise, and work. https://t.co/Q1BYYPihww
Really excited for the next steps of this project to further study whether transgenerational adaptation is universal to different environmental stresses, how conserved this is in other species, and what the precise molecular mechanism is for the transgenerational adaptation. 8/9
This work was spearheaded by @mhafizrothi, @Gautam_Sarkaar, and Joseph Alhaddad, who were helped by Wayne Mitchell, @KejunYing , Nancy Pohl, Roberto Sotomayor-Mena, Julia Natale, Scarlett Dellacono and @gladyshev_lab . Thanks to all the authors! 8/8
Excited to see our manuscript out @NatureComms https://t.co/WrCe69GiFI. We identified that the 18S rRNA methylase DIMT-1 regulates lifespan by functioning in the germline after midlife. 1/8
DAF-9 was previously shown by @AntebiLab to produce the signaling lipid dafachronic acid to signal from the germline to the soma to regulate lifespan. https://t.co/Hkn59wK1hB , https://t.co/dlDNP9xjlL . dimt-1 induced lifespan extension was dependent on this pathway 7/8