Caro and Kancheva et al. generated comprehensive scRNAseq atlases of tumor-associated mononuclear phagocytes (monocytes, macrophages, DCs, and pDCs) across 14 mouse and 10 human cancer settings. 31 murine and 25 human lineage-defined tumor-associated DC (TADC) subsets were identified across cDC1, cDC2A, cDC2B, and DC3 subsets. In tumors, new clusters emerged early on, and as tumors progressed, TADCs adopted a more inflammatory, but eventually less mature phenotype Tumor-mediated reprogramming was also evident within lymph node DCs. In patient data, certain TADC subsets and states were associated with patient outcomes. https://t.co/BYSf45pkVe
Happy to share our latest paper 🎉introducing a patient-relevant orthotopic mouse lung cancer model with SEPERATE-Seq and targeted spatial transcriptomics
Kudos to @laouimmunology.bsky.social, @PaulineBardet and @LizeAllonsius
https://t.co/Mta536LJdX
Our lab (together with #pacoreal) is looking for a PhD student to work on asthma immunology and PDAC!
If you have a strong interest in immunology and cancer biology, check out the ad below #PhDPosition#PDAC#Asthma#CancerResearch
Our new paper is out:
Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive genomic sites and priming pro-tumor gene programs.
https://t.co/u08G5ZKT1b
Happy to share that I’ll be starting my lab as a junior group leader at the Georg-Speyer-Haus in Frankfurt in 2026. We’ll study how transcriptional regulators control neutrophil function in cancer. I’ll be hiring soon (PhD/lab tech), pls reach out if you know someone interested!
Super happy to share our latest in @NatureCancer co-led by @pannunziolab! We review the complex role of the circadian clock in genome integrity, DNA repair, immunity, metabolism, and cancer with a specific focus on early-onset cancer. Check it out!
https://t.co/Wt07GKpWIT
Our new manuscript is now available as a preprint!⛅️
https://t.co/OEPvpN7HpU
1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
1/ Excited to share that my first-author paper is out now in @SciImmunology from @SylviaKnapp_Lab & c-supervised by @MierShawig
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis
🔗https://t.co/IJcoUYCntE
The end of the Early date registrations is approaching!
We are preparing a super fun social and the program is 😍 so what are u waiting? This is the meeting of the year! Disclaimer: already excited about the titles of some talks!
https://t.co/Tm9RDk6Mxw
Congratulations to Lidiia Rumiantseva for turning her PhD research into an engaging presentation of only 180 seconds, and winning the audience award of the KU Leuven 3 Minute Thesis Talk!
Congrats as well to laureate Aarushi Caro!
#3MT#ScienceCommunication#PhDLife
Hamouda et al. engineered LNPs with an ionizable cationic lipid S-Ac7-DOG to improve levels of cargo expression and reduce reactogenicity. https://t.co/lr2kWWiuW0 @ULBruxelles@yBIS_BE@vib_ccb
Are you ready for the Christmas break? Not yet, unless you have signed up for what is meant to be the best conference for 2025! https://t.co/wi4ECaN2PJ
#phagocyte2025 organized by @SEinmunologia and with the support of @EFIS_Immunology@EMBO
🎉Congratulations to Damya Laoui (@Laouimmunology) who received her Commander of the Order of the Crown title from 👑 King Filip yesterday!
➡️ Read more: https://t.co/LGSAHs7hog
🔬 Proud to present a new (and freely available) single-cell RNA-sequencing atlas of the myeloma immune microenvironment across disease stages by @Laouimmunology, Kim De Veirman, Emma Verheye, and colleagues. @FWOVlaanderen@VUBrussel@InflamResCen
👉 https://t.co/qYwUE2g2Qh