When Kaplan–Meier Curves Fool You 📉
A flat survival tail can look exciting…
but sometimes it reflects very few patients remaining under follow-up.
The curve alone is never enough.
Always check: • Number at risk
• Censoring patterns
• Follow-up maturity
• Late-tail denominator
A “long-term survivor plateau” is meaningful only when enough patients are still being observed.
One of the most important lessons in interpreting immunotherapy trials.
#Oncology #MedEd #Biostatistics #Immunotherapy #ClinicalTrials #KaplanMeier #MVOnco
BRCA1/2 may be telling us a bigger story.
A new ESMO Open study suggests that pathogenic BRCA1/2 variants may increase the risk of less common cancers beyond breast, ovarian, pancreatic, and prostate cancer.
Signals observed:
BRCA1 → thyroid cancer
BRCA2 → bladder, head & neck, and skin cancers
The most striking finding:
BRCA2-associated bladder cancer risk appeared particularly high in females.
These data are hypothesis-generating, but they may reshape how we think about hereditary cancer predisposition and precision oncology.
#BRCA #PrecisionOncology #CancerGenetics #Oncology
@ESMO_Open@OncoAlert
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Tens of thousands of kids who take prescription ADHD medication also wind up on other powerful psychotropic drugs—including antipsychotics and antidepressants, studies show. https://t.co/BgSEBlx7ON
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