Florian Altegoer

Junior research group leader at the Institute of Microbiology @HHU_de Interested in Fungal Interactions with a focus on Structural Biology

[Florian Altegoer @FAltegoer]

Excited to see this finally out! Great collaboration @Uni_MR & @SYNMIKRO reinforced by @Team_Thomma. Led by twitterless Paul, we provide a comprehensive structural and functional characterization of a smut virulence factor!

[BangeBalcony @BangeBalcony]

Structural and functional analysis of the cerato‐platanin‐like protein Cpl1 suggests diverging functions in smut fungi - Weiland - Molecular Plant Pathology - Wiley Online Library great work with ⁦@FAltegoer⁩ ⁦@SYNMIKRO⁩ ⁦@Uni_MR⁩ https://t.co/JV9TUMGal6

[Georg Hochberg @KaHochberg]

New paper from us and @erblabs by @schulluc : https://t.co/hN1ikcGFBf. It's about the evolution of essentiality. This question has fascinated me for a long time: How does a component that was previously unnecessary for some function become essential for it?

[GAMA Miguel Angel 🐦‍⬛🔑 @miangoar]

🧵one of my favorite tools: Foldseek (1/7)

We have traced the evo of species by comparing their proteins. We use models that assign a %similarity between seqs and confidently infer that 2 proteins are homologous if share ≥25% SeqSim. But what happens when it’s less than this?

[Kyle Tretina, Ph.D. @AllThingsApx]

Accelerated computing is powering a new era in protein structure prediction, now with speed-of-light multiple sequence alignments.

#MMseqs2GPU now makes #AlphaFold2 predictions faster and more efficient than ever.

1/🧵
https://t.co/Jv45k1PEmO

[Senthil Kumar Devan @DevanSenthil]

We're thrilled to share our new publication: "Deciphering the RNA-binding protein network during endosomal mRNA transport" from the FeldbrueggeLab! 🧬🔬

Check it out here: https://t.co/s81UwFOnoq

#RBP #RNA #mRNA #Endosomes #PNAS #MLLE @HHU_de

[Max Jaderberg @maxjaderberg]

Excited to share that the AlphaFold 3 model code and weights are now available for academic use.
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries https://t.co/GKIOGHm317 1/2

[Polina Isaikina @isaikina_p]

Highlighting the progress in structural biology of GPCR-arrestin signaling with @petrovic_iv. Nearly 600 GPCR-G protein structures vs. only 12 for GPCR-arrestin complexes. What do they reveal about GPCR signaling? Check it out: https://t.co/q88cV28oUy

[Slavica Janevska @Slavi_Jan]

Check out our newest publication on the optimized production of #psilocybin in tryptophan-catabolism repressed fungi, a metabolite with great pharmaceutical potential from the ‘magic mushroom‘ Psilocybe cubensis. Many thanks to everyone involved! https://t.co/UHHVKRMOwI

[Wagner Fagundes @wagnercfagundes]

🚨Preprint alert v.2🚨🤩
I am super excited to share the preprint of another of my PhD chapters in #Zymoseptoria on BioRxiv:
"Interspecies hybridization as a route of accessory chromosome origin in fungal species infecting wild grasses"🧵👇(1/8)
https://t.co/n21hmxoc8L

[Daniel Schindler @DSchindler_PDR]

Are you interested in building DNA? The Golden Gate Cloning book of the #Methods in #Molecular #Biology just went online: https://t.co/zkjC91TjE4
Find superb step by step protocols to harness the power of Golden Gate cloning. Many thanks all authors for their contributions!

[FrunzkeLab @FrunzkeLab]

A highly interdisciplinary endeavour within our SFB Microbial Networking @MibiNet_1535 😊

[Charles Bayly-Jones @bj_charles]

We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳

“LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR”
https://t.co/I7ibRphMzS

🧵

[Sergey Ovchinnikov @sokrypton]

Exciting new work from Qian Cong's group on predicting human protein interactome. Leveraging new eukaryotic genomes, new RoseTTAFold2 trained on +/- pairs of PPI and large distilled dataset of domain-domain interactions! 🤩

https://t.co/vsbJWdNze6

[Martin Pacesa @MartinPacesa]

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton

https://t.co/IPhMFpRgHh

[Khaled A. Selim @Selim_Khaled_]

#joboffer Plz RT & spread words

#SelimLab has open positions (#PhD & #postdoc available immediately) with focus on structural biology #CryoEM & #cdiAMP in #cyanobacteria

Plz apply if you wanna join an international team

#PII #Signaling #proteins #ScienceJobs
@RxivJob @jobRxiv

[FrunzkeLab @FrunzkeLab]

Wonderful and inspiring retreat of CRC „Microbial Networking“ @MibiNet_1535 to Kalkar Wonderland!

@dfg_public @HHU_de @fz_juelich @UniCologne @RWTH @unibielefeld @mpipz_cologne

[Gunther Doehlemann @gun_doe]

Interested in plant cell death?
Great - we have a PhD position for you, available from January 2025 :
https://t.co/ul9xLsMHO8

[Georg Hochberg @KaHochberg]

Our latest preprint: @Sriramgarg calculate a general substitution matrix for structural phylogenetics and used it to root the tree of life.
https://t.co/41a20Bx1SB 1/n

[EMBL-EBI @emblebi]

🚀New update to #AlphaFold Database: Foldseek now integrated!

Peer deeper into evolution with new structure-based search feature to find similar proteins with remote homology. The search includes experimentally-determined protein structures from @PDBe.

https://t.co/9L0RGX0CPx

[FrunzkeLab @FrunzkeLab]

SFB 1535 „Microbial Networking“ @MibiNet_1535 kann auch „Makrobial Networking“ auf der #NachtderWissenschaft.
@HHU_de, @fz_juelich