Fadel Fakih

Third year PhD student at Julius Lukes Lab @BiologyCentre
I am studying tRNAs and translation in protists 🧬☣️

[Fadel Fakih @Fakih98]

My first author paper is published in Nucleic Acids Research, co-led with Satish Nandipati and Ambar Kachale.
In this work, we build on the implications of the unusual genetic code features of Blastocrithidia nonstop and...
#RNA #evolution #phd
https://t.co/dliif822yf

[Fadel Fakih @Fakih98]

Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis
https://t.co/sHagbRPCgm

[Fadel Fakih @Fakih98]

Evolution of tRNA gene repertoires in photosynthetic organisms
https://t.co/YOXPmN4Jjo

[Fadel Fakih @Fakih98]

Leishmania exosomal tRNA-derived small non-coding RNA fragments modulate host THP-1 derived macrophage proteins
https://t.co/uRHqW6rQZY

[Fadel Fakih @Fakih98]

Codon optimization depletes stop codons in alternative reading frames of protein-coding nucleic acid therapeutics
https://t.co/l3xUFY9VdX

[Fadel Fakih @Fakih98]

RNA Cis-Elements Involved in Animal Virus Stop Codon Readthrough: Stop Codon Context and Downstream RNA Structures
https://t.co/sqKSvZJLJ4

[Bloodsucking Parasites @bloodSparasites]

Trypanosomal MICOS Is Assembled on Non-Respiring Mitochondrial Crista Precursors and Associates With Two Integral Microproteins https://t.co/KZPCE3cCW6 PubMed

[Fadel Fakih @Fakih98]

Stop codon reassignment to tryptophan in members of the bacterial phylum Actinomycetota
https://t.co/jNXDRHZjNG

[Fadel Fakih @Fakih98]

MiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa
https://t.co/9nDBZVCLtN

[Bloodsucking Parasites @bloodSparasites]

Evolution of a genome-architecture-encoded gene regulation system in trypanosomatids https://t.co/sKcwASc4lW bioRxivpreprint

[Fadel Fakih @Fakih98]

Anticodon nucleotide modifications affect translational tuning by the ribosomal CAR surface
https://t.co/4FTsoXEv4M

[Fadel Fakih @Fakih98]

A p32 family RNA editing factor acts in mitochondrial ribosome biogenesis
https://t.co/ye9AHlpiuc

[Fadel Fakih @Fakih98]

Reassigning an amber codon to selenocysteine using a functional cysteine suppression pair in Escherichia coli
https://t.co/xKtaXFTWh3

[Physics In History @PhysInHistory]

“I need physics more than friends.”

- Robert Oppenheimer

[Sabine Hossenfelder @skdh]

I hear this argument all the time that people in academia are not there "for the money" and therefore, so the implication, you can trust them.

It's true in the sense that academics didn't chose their profession to become rich-rich. But it's untrue in the sense that they want to keep their job because most of them haven't learned anything else.

They have very strong economic incentives to want to keep their job, even though it won't make them super rich, they probably have a cozy position. And that is why they exaggerate the relevance of their work and ignore shortcomings, because the show has to go on, they need the next grant, the next job, they need to publish the next paper.

No, you cannot trust them to be honest about the relevance of their work, and for the most part you can't trust them to be honest about their colleagues work either, because their income depends on what their colleagues think about them.

[Fadel Fakih @Fakih98]

A newly described role for tRNA: an architectural scaffold that helps organize the mitochondrial RNA-editing machinery of trypanosomes.

#RNA #phd #biology

https://t.co/0gjZBEHoqe

[Fadel Fakih @Fakih98]

Structural basis of the RNA-editing cascade in trypanosome mitochondria
https://t.co/6OKvX05rqI

[Fadel Fakih @Fakih98]

Cryo-EM reveals that Escherichia coli tRNA-transglycosylase can bind and act upon two tRNAs
https://t.co/yM2M3FwLxv

[Re-energising Your Career @career_re]

#AcademicTwitter😂#phdvoice #PhDlife

[tRNA at UCSC Lowe Lab @UCSCtRNA]

Learn about #tRNA #modification across archaeal species in our new paper

OTTR-seq profiling reveals dynamic tRNA modification landscapes across diverse archaeal species
https://t.co/hbmo4d6kqQ

Leavitt et al. Genome Biology (2026)

[Prof. Nikolai Slavov @slavov_n]

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences.  Our @Nature article demonstrates that these predictions miss thousands of protein sequences present in human tissues.

Across >1,000 human samples, we identified numerous abundant proteins whose amino acid sequences differ from those predicted by the genetic code.

These proteins are not rare translation byproducts. They accumulate to thousands of copies per cell. Some are more abundant than the proteins predicted by the genetic code from the same transcripts.

Their abundance reflects a combination of alternate RNA decoding mechanisms — including codon-anticodon mismatches, tRNA abundance, and RNA modifications — and selective stabilization of the resulting proteins. The last factor – protein stability – emerges as a major determinant of protein abundance across proteins, proteoforms and cell types: https://t.co/IzOfAZKnxT

Alternate RNA decoding is pervasive across functional groups of proteins, healthy and diseased tissues. It affects proteins playing key roles in neurodegeneration, and some alternately decoded proteins show strong enrichment in tumors compared to their surrounding tissues.

This discovery has been a long and exhilarating journey with Shira Tsour and the @slavovLab team. It started in 2019 and proceeded through many challenges and thrilling highs. A journey that has opened new perspectives that we long to explore!

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