To the CAR T community-have you ever wondered why there are different affinities around for FMC63 - CD19? We unravelled this mysterium and determined the actual affinity range with different methods in our current paper- just published: https://t.co/s8XLAn5JzV Shares are welcome!
New from my lab: we show that a clinical-stage oncology drug from Eli Lilly is mischaracterized, and its true anti-cancer target is EGFR.
We also show how in vitro drug assays can be misleading - cellular+genetic methods are needed to determine drug MOAs.
Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. https://t.co/oLp8VN0Iiw
PDF: https://t.co/JoKm9BxW89
1/17
Our DREAM paper is out: We found the first master regulator of DNA repair capacities! Read and re-tweet now: The DREAM complex functions as conserved master regulator of somatic DNA repair capacities, @CECAD_@UKKoeln@UniCologne
https://t.co/rVMe4rAxaf
T cells that received telomeres from antigen presenting cells provide durable protection from infection. Congratulations @lanna_alessio !
https://t.co/mj69nXZSF0
Clinical trials success rate by disease area (2010-2020)
**Look at Hem rate of success from Ph2-Ph3: 48%
while Oncology is at 25%
https://t.co/eGa0u9S3Mq
my first paper! we used an old(?) hypothesis about IL-2 to get better affinity/specificity while *only* designing for stability. Also, no library screening needed :)
https://t.co/4qLpxJdrJp
I am excited to share a new study led by Shachar Givon & @MatanSamina w/ Ohad Ben Shahar: Goldfish can learn to navigate a small robotic vehicle on land. We trained goldfish to drive a wheeled platform that reacts to the fish’s movement (https://t.co/ZR59Hu9sib).
Best way to ring in the new year! @erika_alden_d and I are excited to share our story on high-throughput continuous evolution, available now in @naturemethods. We've added a ton to the story since the preprint, and hope you'll check it out! thread 1/n... https://t.co/e76mfVIlNN
So we can conclude that the new molecule is a potent anti-HER2 agent able to:
- Induce HER2 internalization
- Inhibit cellular proliferation
- Cause cellular apoptosis 12/n