I spent my PhD developing novel genomic technologies, and today I am extra excited to share the last bit of this work, which is a multiplex prime editing (PE) screening framework! (1/n) https://t.co/b0eyLi2snP
I have only amazing things to say about @sdomcke - her lab will be one of the best out there, both from a scientific and mentorship perspective. I can't wait to visit!
New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4
News & Views article by Jesse and Alex on our RA-gastruloid model! Big thanks to @alex_schauer_ and @jvveenvliet for their insightful summary of our RA-gastruloid paper. The article also provides an overview of current stem-cell-based embryo models (SEMs) fields and future directions with beautiful images. Highly recommended for anyone interested in the latest developments in SEMs!
https://t.co/pBqVOoRsFu
Incredibly proud to share that I recently joined @UCSF_BTS@UCSF as an Assistant Professor! This means that the Calderon Lab is now open!
Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳
Another phenomenal piece of work from a superstar postdoc and my closest collaborator @TroyMcDiarmid, & incredible (now PhD student!) Megan Taylor! Megan joined the lab as a freshman undergrad, & it has been nothing short of amazing watching her develop into an amazing scientist.
Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” !
https://t.co/8BtGh7th6P
Genomic tech dev is my favorite area of science, and today our paper describing our multiplex CRISPRa screening method to identify cell type specific regulatory elements is published! https://t.co/KWmdWZlDpn
Thanks @JShendure for the second-to-none mentorship and scientific guidance, and a big thank you to @NadavAhituv for your guidance and prudent insights in regards to the development of this method and work!
I also feel lucky that my interests outside of lab aligned so well with so many Shendure lab members! How special is it to have labmates that will go skiing with you before work? :) (also pictured is @sdomcke, another wonderful collaborator)