Will Chen

@DamonRunyon Fellow at Baker lab @UWproteindesign. PhD with @JShendure. mainly at

[Will Chen @wchenomics]

Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously.
https://t.co/whJgHAm3nO

[Katie Galloway @GallowayLabMIT]

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

[Chengxiang Qiu @CXchengxiangQIU]

New preprint! @JShendure @CXchengxiangQIU Can we learn regulatory grammars of human cell types we'll never be able to profile - by training on mouse development and transferring across 241 mammalian genomes?https://t.co/sWCWoAqJ2B

[William J. Greenleaf @WJGreenleaf]

Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! https://t.co/iUiZz00KOt

[Will Chen @wchenomics]

absolutely excited to see @CXchengxiangQIU starting his own lab at Dartmouth! Great adventure awaits!

[Chengxiang Qiu @CXchengxiangQIU]

Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! https://t.co/8lHVDt3dHP

[Max Wilkinson @maxewilkinson]

The Wilkinson Lab is open for science! @MSKCancerCenter

🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

[Jay Shendure @JShendure]

Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & @Green_Ahn @UWproteindesign on the work! Preprint:
https://t.co/7gh8ZtcKUO

[Andrew Favor @andrew_favor]

We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”.
This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6)
https://t.co/QPqpNZr0er

[Green Ahn @Green_Ahn]

pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint https://t.co/ovuJf8D6m4, we developed computational methods to rationally design pH-sensitive binders. 🧵

[Adam Broerman @adam_broerman]

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

[Magnus Bauer @kinasekid]

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: https://t.co/iIucGbMSDp

[Will Chen @wchenomics]

Congrats @JingchuanLuo. Really novel way to study localized translation.

[Jingchuan Luo @JingchuanLuo]

I'm thrilled to share our work from @JswLab (https://t.co/CMzQznSXPN). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

[Will Chen @wchenomics]

@LukeKoblan @ScienceMagazine Congrats Luke! Such a detailed and beautiful paper!

[Will Chen @wchenomics]

I am thankful for the feedback from @JShendure, the support from @UWproteindesign and @DamonRunyon.

[Will Chen @wchenomics]

Molecular recording is an emerging field with exciting applications. In this review, @_Choi_Junhong and I outline major challenges that the community should address to fully realize the potential of this technology, and highlight promising directions that we are heading.

[Trends in Genetics @TrendsGenetics]

Molecular circuits for genomic recording of cellular events https://t.co/rsiNHn2Nbo

[Will Chen @wchenomics]

Beautiful work! congrats @yodai_takei !

[Yodai Takei @yodai_takei]

Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! https://t.co/0LC2GlEpQs

[Will Chen @wchenomics]

Congrats @JONA. such beautiful paper

[Jonas Koeppel @JonasKoeppel]

I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine!

@ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @SangerInstitute

https://t.co/UtJ13iNRAq

Lots of changes from the preprint. A🧵

[Will Chen @wchenomics]

Congrats on this beautiful paper! @sudpinglay

[Sudarshan Pinglay @sudpinglay]

Now out in @ScienceMagazine we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

https://t.co/dKnuHkQ0W9

[Zibo Chen @ZiboChen]

Excited to finally share Perceptein, a PERCEPtron made of proTEINs: https://t.co/saaO8ogAc3

[Junyue @junyue_cao]

Finally out in @ScienceMagazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes across five life stages and diverse sexes/genotypes, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows. We also demonstrate how highly scalable single-cell genomics enables "Functional Cell-omics" to unravel Cell Regulatory Networks at the whole-organism scale. Congratulations to the incredible Zehao Zhang (@Tommyz626) from our lab @RockefellerUniv for leading this work! https://t.co/mXIZDrV9Mq

[Will Chen @wchenomics]

@tranmartink clarify: the editorial team made the final figures based on the amazing figures made by the above two.

[Will Chen @wchenomics]

Such an enjoyable journey to write this review with all the amazing scientists. glad to see it's finally out. A big shout out to Lucia and @tranmartink on their amazing illustrations!

[Nature Reviews Genetics @NatureRevGenet]

The lives of cells, recorded https://t.co/etnZ4iqnC4 #Perspective by @AskaryLab, Wei Chen, @_Choi_Junhong, Lucia Y. Du, @ElowitzLab, @james_gagnon, @schierlab, @sophieseid, @JShendure, @TanjaStadler_CH & @tranmartink