Florian Sicklinger

Physician-Scientist, investigating innate immunity in cardiovascular disease @uniklinik_hd

[Leuschner Lab @LeuschnerLab]

No longer the forgotten valve.

Check out our latest preprint on how tricuspid regurgitation accelerates heart failure.

https://t.co/tyWSFhUoRA

[Matthias Nahrendorf @MatthiasNahrend]

cool paper alert
👇
https://t.co/EPhPDJ6lwp

[Florian Sicklinger @FloSicklinger]

Using the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure.

https://t.co/gzRUInRPvS

[ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE @DucheneJohan]

Do we study the right biology after myocardial infarction (MI)?
• Surgery in standard mouse model masks MI-specific immune responses
• Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function
https://t.co/MIDaP9lSgs

[Hao Yin @HaoYin20]

#SpatialOmics #MyocardialInfarction
#MolecularCartography 100-gene + #SeqIF 12-marker + #DeepVisualProteomics
4/24/49/96 h postMI🐭

Endocardial vWF mediates Mɸ infiltr
Anti-vWF i.v. reduces Mɸ at endocardial, but not epicardial, core or border, zone, but causes infarct wall thinning + worsened cardiac adaptation by 2 wk

Cellpose 2 human-in-a-loop for CardioMyocyte segmentation
Ankrd1 pixel cluster to demarcate stressed/dying CM

Custom analysis pipeline
https://t.co/EtKZk9sUsT

@flowuenne @FloSicklinger @DenisSchapiro @NatureCVR 2025
https://t.co/4dSZK5ZLbh

[Waggoner Lab @LabWaggoner]

von Willebrand factor is upregulated after myocardial infarction and facilitates recruitment of Ccr2+ monocytes that worsen cardiac function
@flowuenne @FloSicklinger @DenisSchapiro
https://t.co/ldDheDJiAj @NatureCVR @HeidelbergU @uniklinik_hd 🇩🇪

[Rafael Kramann, MD PhD @rkramann]

Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab @MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver

[Circulation Research @CircRes]

Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at https://t.co/yqrOd4AS7o

@volkersmirko @junedh_amrute @rkramann

[Leuschner Lab @LeuschnerLab]

Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢

[Florian Sicklinger @FloSicklinger]

@AsAshraf123321 @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thank you !

[Florian Sicklinger @FloSicklinger]

In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion.

Check out the full study here: https://t.co/5uQP5k7Ref

Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF

[Florian Sicklinger @FloSicklinger]

@SusannaTECooper @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thank you Susanna !

[Florian Sicklinger @FloSicklinger]

@KuppeChristoph @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thanks Christoph !

[Florian Sicklinger @FloSicklinger]

@T_Thiemann @junedh_amrute @LauraWienecke @dav_schumacher @TimChristianKu1 @CRC1550

[Junedh M. Amrute @junedh_amrute]

In ⁦@Nature⁩ we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with ⁦@LavineLab⁩ ⁦@washumedicine⁩, ⁦⁦@Amgen⁩ , and ⁦@ImmunoFibHF⁩ https://t.co/xyzLItDYmk

[Christoph Sandmann @chris_sandmann]

Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
https://t.co/xWORVd0MKd
This work was a huge collaborative effort over many years.
@dzhk_germany @DGK_org @VolkersMirko
Key findings + paper summary below 🧵⬇️⬇️⬇️

[Mirko Volkers @VolkersMirko]

Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550 @dzhk_germany @uniklinik_hd https://t.co/Ormsibt4ul

[Florian Sicklinger @FloSicklinger]

Thanks to @BronwynBerkeley for highlighting our method in @NatRevCardiol

[Bronwyn @BronwynBerkeley]

Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction:
https://t.co/GNFn4rSA3L

Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.

[Leuschner Lab @LeuschnerLab]

A shortcut to the infarcted heart

Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.

https://t.co/cOO80X7L9M

[Denis @DenisSchapiro]

I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. https://t.co/DE8K2i0S14