Leuschner Lab

Heisenberg Professorship for Immunocardiology @Uniklinik_hd

[Leuschner Lab @LeuschnerLab]

No longer the forgotten valve.

Check out our latest preprint on how tricuspid regurgitation accelerates heart failure.

https://t.co/tyWSFhUoRA

[Matthias Nahrendorf @MatthiasNahrend]

cool paper alert
👇
https://t.co/EPhPDJ6lwp

[Florian Sicklinger @FloSicklinger]

Using the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure.

https://t.co/gzRUInRPvS

[Leuschner Lab @LeuschnerLab]

Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢

[Circulation Research @CircRes]

@CircRes May 9th Issue is Out! https://t.co/IiX6g6rOKd

Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.

[Florian Sicklinger @FloSicklinger]

In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion.

Check out the full study here: https://t.co/5uQP5k7Ref

Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF

[Leuschner Lab @LeuschnerLab]

scRNA-Seq profiling of 🫀interstitial cells reveals fibrosis in HFpEF to be distinct from HFrEF including the induction of basement membrane collagens and a protective ⬆️ of ANGPTL4 in murine and human HFpEF | led by @LauraWienecke and @jan_lanzer

https://t.co/DgALDoP5Zn

[Laura Wienecke @LauraWienecke]

What do Angptl4 and collagen IV have to do with fibrosis in HFpEF?🫀 Proud to have found some answers!🔬 Thanks to my co-first @jan_lanzer, all authors and our supervisor team for excellent support @LeuschnerLab @JulioSaezRod 👌🏻 https://t.co/OMUSJZ3hQU

[Basic Research in Cardiology @BasicResCardiol]

Molecular fibroblast activation patterns in heart failure.
https://t.co/HyUpgUrk9b

[Christoph Sandmann @chris_sandmann]

Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
https://t.co/xWORVd0MKd
This work was a huge collaborative effort over many years.
@dzhk_germany @DGK_org @VolkersMirko
Key findings + paper summary below 🧵⬇️⬇️⬇️

[Bronwyn @BronwynBerkeley]

Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction:
https://t.co/GNFn4rSA3L

Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.

[Vesna Todorović @Vesna_Tod]

Couldn't attend the #Immuno-#Cardiology Symposium @FondationLeducq @jacksonlab? No problem-> read the report 'Linking immune modulation to cardiac fibrosis' here 👉 https://t.co/5GgL6sXm26
#fibrosis #cardioimmunology

[Leuschner Lab @LeuschnerLab]

Great support by @CosciaLab @saezlab @LavineLab

[Leuschner Lab @LeuschnerLab]

A shortcut to the infarcted heart

Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.

https://t.co/cOO80X7L9M

[Denis @DenisSchapiro]

I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. https://t.co/DE8K2i0S14