Jan Lanzer

MD/PhD @saezlab, with interest in computational biology and cardiology

[Jan Lanzer @jan_lanzer]

Glad to share this online: we’ve expanded our transcriptomics meta-analysis of heart failure to the multicellular level. Check out how you can use this reference to support your own data analysis! This was another rewarding team effort w @roramirezf94 #HeartFailure

[Saez-Rodriguez Group @saezlab]

What are the key disrupted multicellular processes in heart failure? In our new work we combine 23 years of molecular data with recent single-cell atlases to draw a cross-study patient map. How did we navigate the heart failure space? 🧵⬇️
https://t.co/aRDqdQxC5j

[EMBL-EBI @emblebi]

Organoids have incredible potential in drug discovery and disease modelling.

In this Scientific Computing World interview, @Iguaracysousa discusses organoid construction, nanobots, and how bioinformatics is transforming biomedical research.

https://t.co/5iyI549Mo5

[Lukas Hatscher @LukasHats]

We are looking for a PostDoc with strong computational expertise to join our lab with a focus on computational tissue biology:
https://t.co/LE55mFesUj

[Junedh M. Amrute @junedh_amrute]

We use Multiome and HiC to build a comprehensive single cell variant to enhancer to gene map for coronary artery disease. Join effort with @PaulChungrohLee and IttaiEres in Nate Stitziel Lab and in collaboration with @Amgen @WUSTLmed
https://t.co/bM6RPUcUEW

[Dominic Grün @dominic_grun]

Excited to share our study on spatio-temporal reconstruction of cardiac scar formation led by @ChanAndyson. We combine scRNA-seq with spatial transcriptomics to resolve the fibrotic niche and the niche of dedifferentiating cardiomyocytes. https://t.co/LHlktVYU4W

[Jan Lanzer @jan_lanzer]

@science_wallet @roramirezf94 @saezlab Thank you @science_wallet !

[Jan Lanzer @jan_lanzer]

@chris_sandmann @saezlab Thank you! 🙏

[Saez-Rodriguez Group @saezlab]

Our work with @schirmerlab in multiple sclerosis (MS) is out today in @NatureNeuro. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️
https://t.co/j6LIwv4IgU

[Saez-Rodriguez Group @saezlab]

📢 Introducing CORNETO: a unified, knowledge-driven framework for multi-sample network learning & modeling via constrained optimization, supporting a wide variety of network methods and prior knowledge

💻Code: https://t.co/OuM9Acrs9U
📜Paper: https://t.co/XFjEbKMAAL

🧵👇

[Jan Lanzer @jan_lanzer]

@PauBadiaM @NatureNeuro @Cels121 dream team. Congrats!

[Malte Luecken @MDLuecken]

Are you interested in sc-spatial multiomics data, motivated by improving patient outcomes in lung cancer, and keen to join a young and growing lab taking single-cell atlassing to clinical applications? Please apply :). We're looking for Postdocs!

https://t.co/l3iEgt1gIB

[Jan Lanzer @jan_lanzer]

Check out our work on fibroblast activation patterns in HF models! Huge thanks to my co-lead @LauraWienecke 🙏 from @LeuschnerLab!

[Leuschner Lab @LeuschnerLab]

scRNA-Seq profiling of 🫀interstitial cells reveals fibrosis in HFpEF to be distinct from HFrEF including the induction of basement membrane collagens and a protective ⬆️ of ANGPTL4 in murine and human HFpEF | led by @LauraWienecke and @jan_lanzer

https://t.co/DgALDoP5Zn

[Jan Lanzer @jan_lanzer]

@JamesCranley @mallat_lab @kazukane @teichlab Congratulations, James!

[Jovan Tanevski @tanevski]

🚨 We are looking for a PhD student 🚨 to join the Tanevski Lab and @DenisSchapiro Lab at the Heidelberg University Hospital, working at the intersection of machine learning and spatial omics as part of the Translational Spatial Profiling Center. Please RT https://t.co/3bR3SUVjLO

[Jan Lanzer @jan_lanzer]

Congrats Julio!!

[EMBL-EBI @emblebi]

We welcome Julio Saez-Rodriguez @JulioSaezRod as our new Head of Research!

Associate Director for EMBL-EBI Services Jo McEntyre @jomcentyre has been promoted to Deputy Director of EMBL-EBI & Rolf Apweiler is stepping back to Associate Director as he looks towards retirement.

[EMBL-EBI @emblebi]

We welcome Julio Saez-Rodriguez @JulioSaezRod as our new Head of Research!

Associate Director for EMBL-EBI Services Jo McEntyre @jomcentyre has been promoted to Deputy Director of EMBL-EBI & Rolf Apweiler is stepping back to Associate Director as he looks towards retirement.

[Jan Lanzer @jan_lanzer]

See this great perspective by @roramirezf94 and others on multicellular processes and how to study them using single cell omics!

[Saez-Rodriguez Group @saezlab]

How to link single-cell diversity and the emergence and maintenance of robust multicellular processes in developed tissues? 🤔

What can we learn about multicellular coordination in tissues from single-cell omics data?

Read about our view: https://t.co/z5msHv5EgB

[Jan Lanzer @jan_lanzer]

@deigsmnns Great job, Diego!!

[Saez-Rodriguez Group @saezlab]

1) Are you interested in computational approaches to study the immune system 🔎🦠by integrating single-cell + spatial multi-omics data with prior knowledge? Check our review 📖out now in @NatImmunol https://t.co/ilWxyshOLR 🧵

[Saez-Rodriguez Group @saezlab]

Our @jan_lanzer will present his work (together w @roramirezf94) on multicellular programs in heart failure at #EMBOCardioBiology this week. Come find him if you are interested in how we can leverage public single cell atlases to study coordinated events in myocardial remodeling