Quentin Frenger

PhD in immunology.
Postdoc @MEMBRAMICS_Lab @NeckerINEM.
Interrested in autophagy related proteins functions in response to cellular stress

[Quentin Frenger @FrengerQuentin]

My first postdoc preprint is out!

Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis.
https://t.co/YPpVj09IHW

[Quentin Frenger @FrengerQuentin]

@RobertoZoncu @JayXiaojunTan @clairegoul @aakritijain24 Amazing work congratulations !

[Roberto Zoncu @RobertoZoncu]

Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. https://t.co/ZdGtlU0wke

[Ali H. Shaib @AliHShaib]

Hello world, meet 1,000× Expansion Microscopy.
1,000,000,000× expansion by volume! A gel that starts at a few centimeters will then expand to the volume of an Olympic swimming pool. https://t.co/E43kxx4O5M
In our new bioRxiv preprint, work carried out between MIT and UMG, led by Helena Hu in collaboration with scientists from the labs of @eboyden3 Ed Boyden, Silvio Rizzoli, and myself, we present Thousandfold Expansion Microscopy.
By enlarging biological specimens across multiple rounds of expansion, molecular-scale features, as small as the distances between adjacent amino acids, can be visualized with conventional optical microscopes.
Democratizing super-resolution microscopy.

[Fernando Martin-Belmonte @Fernand49142950]

Excited to share our new study in @NatureComms!
We uncover a key role for noncanonical autophagy (CASM) in neural tube formation through mb remodeling and endocytic recycling.
Using human neural tube organoids, we reveal mechanisms that may be relevant to neural defects. 🧠🧬

[Mark Hahnel @MarkHahnel]

Anthropic tests Claude Operon for scientific research in biology

Operon is a new Claude desktop app mode designed for biology and health research, featuring dedicated project tools and session management.

https://t.co/ZOHwg7IOaQ

[Nature Methods @naturemethods]

NimbusImage: a cloud computing platform for image analysis.

https://t.co/6DKNLCQNMV

[Cell Biology J-Club @cell_club]

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation https://t.co/LYbW2esBSg

[bioRxiv Cell Biology @biorxiv_cellbio]

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation https://t.co/aoNe1MGo6k #biorxiv_cellbio

[Quentin Frenger @FrengerQuentin]

Big thanks to Etienne Morel and all the MEMBRAMICS lab! @MEMBRAMICS_lab

[Quentin Frenger @FrengerQuentin]

My first postdoc preprint is out!

Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis.
https://t.co/YPpVj09IHW

[Cell Biology J-Club @cell_club]

LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses | bioRxiv https://t.co/Dxon8ftAXI

[David Usharauli @3DiMMUNE]

As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.

#immunology
#science
#tumor
#immunotherapy

https://t.co/Jlja2ejxDS

[Quentin Frenger @FrengerQuentin]

What a beautiful time at the European Intermediate Filament Meeting 2025 in Lyon! I was so glad to meet such a welcoming community.

I'm honored to have won the Best Oral Communication Prize for my recent postdoc project on Vimentin and Autophagy!

Huge thanks to the organizers!

[Cell Biology J-Club @cell_club]

ATG16L1 controls mammalian vacuolar proton ATPase https://t.co/yQf9XcBLM6

[Jay Tan @JayXiaojunTan]

Lysosomal vacuolation has been observed for decades in many diseases.

Today in @ScienceMagazine, we report LYVAC/PDZD8-mediated directional, ER-to-lysosome lipid transfer as an essential mechanism for lysosomal vacuolation.

https://t.co/yrklDE9plq

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease https://t.co/GNxTEmauEZ

[Journal of Cell Biology @JCellBiol]

Borisyuk, Kaganovich, Amen et al. (@EPFL_en @unisouthampton) show that PKC promotes peroxisome-ER interactions and #peroxisome formation. https://t.co/bLTwPnT3v9

▶️ See video summary of the study by Howman: https://t.co/VSVigh0J2k

#ER_literature

[Journal of Cell Biology @JCellBiol]

.@LabYuseff @uc_chile show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation https://t.co/9oNDESDNSt

[Cell Biology J-Club @cell_club]

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell https://t.co/UU9x6DLpZg

[Jay Tan @JayXiaojunTan]

Excited to share our latest review "Lysosomal Repair in Health and Disease". We summarized how cells repair lysosomal damage via 4 distinct strategies and discussed the implications for aging, neurodegeneration, cancer, infection, and more.
Open access: https://t.co/Pg5wD5CBKC