Greta Frisone

[Eric Topol @EricTopol]

Severe Covid leads to persistent viral reactivation, with >10 different viruses noted in the first 40 days after hospital admission.
Long Covid was specifically associated with reactivation of latent Anelloviridae virus
Work based on 1,154 patients in 20 centers and >200,000 samples
@nature
https://t.co/IjhNhT1HRX

[Elly Bailey @ellbail]

@internetuserf12 Tributyrate is particularly helpful for me

[Michael Moran | APC Injury @internetuserf12]

Some of the strongest therapeutic signaling in Long Covid research comes from treating the microbiome, specifically with SIM01 and similar formulas that increase bifido and SCFAs.
https://t.co/oUzC3tOcw8

[MECFS, MCAS and PTSD @FatigueMe92484]

I tried it when I had PEM. It helped both with cognitive clarity and maybe some PEM fatigue. I am not taking it now because I am in the mild stage. I really can't afford to take a lot of supplements when I don't need too! I also don't think it is necessary. That said, it did help I think when I needed it.

[Carole Bruce @CaroleBruce17]

Has anyone tried Creatine? Any advice? Just wondering.
#ME

[MECFS, MCAS and PTSD @FatigueMe92484]

Glymphatic clearance is a big part of my model. I believe MECFS totally screws with the astrocyte-neuron lactate shuttle which controls AQP4 production. AQP4 is needed for proper function of the glymphatic system.

[Dalton (Analyze & Optimize) @Outdoctrination]

L. reuteri appreciation post - something I've seen benefit a ton of people for gut / immune / metabolic health.

L. reuteri is one of the most well-studied probiotic strains, but its benefits extend far beyond digestion.

L. reuteri levels are often reduced in people with gut dysfunction, chronic inflammation, or after repeated antibiotic use.

It acts to:

◇ Strengthen the gut barrier
◇ Support a healthy immune response
◇ Reduce intestinal inflammation
◇ Produce antimicrobial compounds that help keep harmful bacteria in check
◇ Support oxytocin production
◇ Improve gut motility

We mostly opt for DSM 17938 or ATCC PTA 6475 strains - 1-5 billion CFU a day is a good starting point.

[Ziv @biohackerziv]

For a deeper scientific breakdown of how individual micronutrients dictate your physiology—so you can avoid 90% of the chronic issues normies deal with: https://t.co/3qtVZRPWE5

[Ziv @biohackerziv]

90% of your gut problems like leaky gut, SIBO, gas, bloating, food allergies, constipation, loose stools, and other issues like hypothyroidism, low energy, sleep issues, ADHD, low motivation, depression, low testosterone, high estrogen and 100+ different "illnesses" can be fixed by simply correcting nutritional deficiencies.

Here's how👇

1. The Gut

SIBO, chronic constipation, and bloating are rarely random bad luck; they are mechanical failures of the Migrating Motor Complex (MMC). The MMC regulates gut motility and runs on the neurotransmitter acetylcholine. Synthesizing acetylcholine requires massive amounts of Thiamine (B1) and Pantothenic Acid (B5). Deplete these B-vitamins, peristalsis halts, bacteria ferment, and endotoxin accumulates.

2. Hypothyroidism

Hypothyroidism in most cases is conversion failure, not a glandular failure. The liver requires specific deiodinase enzymes to convert inactive T4 into metabolically active free T3. These enzymes are strictly dependent on adequate Selenium, Zinc, and Vitamin A. A clinical-grade multivitamin bypasses this bottleneck, forces active thyroid hormone production, and clears the endotoxin burden.

Following a Ray Peat style high fruits diet also helps the most as the liver needs glycogen to convert T4 into T3 and keep cortisol low so T4 doesn't get into the rT3 pathway and block T3 from working even if you take exogenous.

3. The Dopamine Synthesis Bottleneck

ADHD, low motivation, and lethargy are the direct result of stalled catecholamine synthesis. The enzymatic conversion of tyrosine into dopamine strictly requires Pyridoxal 5'-Phosphate (active B6), Folate, and Iron as cofactors. When you lack the raw molecular material, dopamine flatlines.

4. Mitochondrial ATP Stalls

Chronic lethargy and disrupted sleep architecture are the result of a halted Krebs cycle. Cellular ATP production is entirely gated by Riboflavin (B2), Niacin (B3), and intracellular Magnesium. When you supply the metabolic cofactors, mitochondrial output scales up, sympathetic nervous system drive drops, and circadian rhythms auto-regulate.

5. The Bioavailability Distinction

You cannot fix these pathways with generic, low-tier multivitamins loaded with cyanocobalamin and magnesium oxide. You require methylated B-vitamins (L-methylfolate) and chelated trace minerals (glycinate/picolinate) to bypass genetic MTHFR polymorphisms and ensure direct intracellular uptake.

6. The Intervention

Stop chasing symptoms with 15 different localized treatments. Pathology scales downstream from enzymatic cofactor deficiency. Flood the system with a clinical-grade, highly bioavailable Vitamins and Minerals. Restore the enzymatic pathways, restart gut motility, upregulate T3 conversion, and watch the distinct "diseases" resolve themselves.

7. Never take high doses of anything in isolation

You will be relieved for some time as you corrected a deficiency, but if you force one metabolic pathway open with massive amounts of isolated B1, you will instantly create a relative deficiency in B2 and B3 downstream, stalling the Krebs cycle in a new location.

Here's what to do👇

For sedentary people, just take Thorne Basic Multivitamin 2x.

For people who have an 90% sedentary life but do cardio and gym, add extra 100mg magnesium glycinate with each meal (2-3x) and Fat Soluble Vitamins A, D, K, E (IdeaLabsDC Estroban).

For advanced people, athletes, entrepreneurs, and high performers who want all things optimized and maxed out, add extra 15-30mg Sucrosomial Zinc, 3-6mg copper glycinate, 5-10k IU Vitamin D3 and 1g vitamin C with each meal (2-3x), along with a B100 complex.

(No matter what you eat, your food will never match what these things will provide, and in 2026, with that many toxins and pollutants around us, we need way more than what our food provides. If you want to sit on the couch all day and doomscroll, then sure, but if you want to achieve something and run better than average people, then...)

[Dalton (Analyze & Optimize) @Outdoctrination]

THIAMINE FORMS CHEAT SHEET:

B1 is helpful for:

➥ Fatigue
➥ Brain fog
➥ Reducing inflammation
➥ Digestion / gut motility

and so much more.

There's multiple forms you can supplement with.

TPP is the active form of thiamine that our cells use.

This is your guide to picking

[Dalton (Analyze & Optimize) @Outdoctrination]

Sodium butyrate treats IBS at the root cause.

300-600 mg / d improves literally EVERY symptom of it:

⬩Abdominal pain
⬩Urge sensation
⬩Stool consistency
⬩Constipation
⬩Abdominal pain
⬩Flatulence
⬩Diarrhea
⬩Nausea
⬩Vomiting
⬩Markers of inflammation
⬩QUALITY OF LIFE

ALL by 50% or more.

This is because IBS is defined by impaired gut bioenergetics, pathogenic bacterial overload, inflammation and immune dysregulation.

In other words, it is often a butyrate deficiency.

[🕸️Dr.T, PhD @chydorina]

This is me. Actual real data.

I came across the Born Free Protocol a few months after I had developed and finalized the Remission Biome Protocol. BF filled in the gaps in RB and was simply better in every possible way. I already knew that there were dozens of missing elements in RB and I tried to hit all the nails that needed to be hit - be ultimately I knew it would fail.

RB may have been extensive for the time (this was in 2021) but it was missing so many key vitamins, co-factors, nutrients, aminos, and other elements that it was like a toy version of BF. It also had a weak model and indeed - was too dangerous for this patient population in particular to be done without knowledgeable physician oversight.

Then I met @joshual_tm. You know when you see a body of work and it just dots all the i's and crosses all the t's and indeed - fills in all the blanks? BF did this. It set people up with strictly ordered interventions so that failure would be very unlikely if done properly. It represented and represents a REAL chance at actual recovery through every pathway I had identified as key and needing attention. It was/is comprehensive and quantitative and based in systems biology - and as such appealed to how I viewed human biology.

Now, with the latest tools and integrations with https://t.co/DViUNfCQYQ for metabolomics and microbiome, Oligoscan, Biomesight, and OAT tests it has become personalized and actionable and incredibly powerful (see below).

This is my data. My metabolic dysfunction on display. I do have faith in it! Yes. Just not the way people mean when they use that word.

[Noah Ryan @NoahRyanCo]

L theanine is the closest thing we have to a meditation molecule. This amino acid increases Alpha brain waves, the specific bands needed to reach that "alert but calm" state required for mediation.

There's a reason green tea is popular in zen culture and matcha (highest concentration of L-theanine) became a meditation ritual in and of itself.

Alpha waves reflect synchronized neural activity best described as relaxed wakefulness.

This is the exact state that we're missing. We're either mentally fried or aggresively overstimulated. Too much time in narrow, whiteknuckled focus and not enough in creative, diffuse mode thinking.

Monks spend years optimizing for this brain wave state. Some of us don't have as much time. Using tools like L theanine can make the transition to a meditative state easier and more effective.

[Andrew Green @AndrewG76201347]

@LucienDorman Re preventing PEM, son & I have both found rapamycin has significantly shifted the needle—I’ve had 2 PEMs in a year, son 0 in 5mths. Plus baseline activity increased a notch. PEM itself still the same (36hr delay, lasts 5-7 days). Still need to pace.

[Ziv @biohackerziv]

Snorting this weird Soviet chemical fixed my sleep issues, morning brain fog, removed food allergies, fixed gut issues like SIBO, leaky gut, constipation, loose stools etc. and chronic back and joint pain.

Now for the science nerds, Here' what it is and how it works 👇

Morning brain fog isn't just "tiredness"—it’s acute [Reactive Oxygen Species / ROS] accumulation and mitochondrial stress from a broken circadian rhythm.

Normies chug coffee to merely block adenosine receptors. Epitalon drops a nuke on the waste itself.

Epitalon violently recalibrates [BMAL1/CLOCK] gene expression, overriding the broken biological clock and tricking your CNS into a full diurnal reset.

This BMAL1/CLOCK reset is the ultimate biological skeleton key for your gut.

The Migrating Motor Complex (your gut's mechanical sweeper) is entirely circadian-dependent. Lock in your internal clock, and you aggressively restore morning stool frequency, fixing chronic constipation, SIBO, and gas at the root.

This systemic Nrf2 surge is also why your chronic back and joint pain vanishes. It scavenges the excess ROS that directly upregulates cartilage-eating enzymes in avascular spinal discs and joints.

If your biological clock is broken, you are trapped in a groggy twilight zone.

Because it is modeled on a pineal gland extract, Epitalon exerts a profound regulatory effect on the endocrine system, specifically concerning melatonin.

It alters the expression of proteins like AANAT (the rate-limiting enzyme in melatonin synthesis) and pCREB.

Since your gut uses 400x more melatonin than your brain, this localized surge aggressively seals leaky gut tight junctions and halts the localized inflammation causing loose stools.

This is also the exact biological mechanism to fix "permanent" food allergies. Your sudden sensitivities aren't a genetic curse—they are an immune panic attack caused by that permeable gut lining letting undigested proteins leak directly into your bloodstream.

By sealing those tight junctions with gut-level melatonin and resetting the circadian rhythm of your mast cells, Epitalon stops the systemic histamine dumps. You stop reacting to every single thing you eat because the structural leak is finally closed.

"🤓👆so i can just snort this everyday and ignore my lifestyle"

No, genius. If your system is wrecked, acute effects can be hit or miss. Its true power is restructuring your internal clock so you don't have paralyzed gut motility, random food allergies, or chronic joint inflammation to begin with.

It’s not a band-aid; it is a fundamental, ground-up rewrite of your sleep architecture and systemic inflammation.

Also, I also have some esoteric beliefs about the pineal gland, so anything that helps it, I take it.

[John Haughton MD, MS 🌻 @doc4care]

And there are simple, effective ways to quiet TLR4 inflammation (metformin, berberine, curcuminoids, low dose naltrexone, low dose lithium). And for quieting the RAGE pathway low molec wght heparin (or if outside IS, sulodexide - essentially, oral heparin - not approved in U.S.)

[Ross 🧬🔬 @GutOptimized]

Imperative to understand how easily mineral dysregulation or excretion occurs when your body is under stress and/or inflamed.

We are all go with work and exercise while being stressed out on our phones - 24/7.

Add health issues into that.

Yes, you're doing to be dehydrated and imbalanced.

[🕸️Dr.T, PhD @chydorina]

The brilliance of the Born Free Protocol is what is built into it. It's not the sum of it parts - so much of its power is built in to it with timing and order and interactions.

In most approaches and protocols treating severe cases is so different from treating mild cases that it mostly makes sense for those camps to pretty much ignore each other.

Born Free tackles issues in a very crucial ORDER and for some people (if mild, sick for short period of time, few previous triggers and comorbidities) they might even get away with only needing the first Stage or 2 of the protocol.

MDs typically do not treat conditions like ME - they use drugs for symptom control. NDs and health coaches try and treat but they often focus on interventions based on order of dysfunction (i.e. what is causing a patient the most grief) rather than biochemistry and metabolic function. This cannot work.

It may be, for example, that pathogens are your biggest issue but it does not mean that is where you should start right off the bat.

Just understanding why Born Free is structured the way it is - is helpful. Whether you follow it line for line or not - understanding the ORDER of introduction for interventions will help you.

The new wizard is great. Try it. @joshual_tm https://t.co/DxPFA9Ysat

[Dalton (Analyze & Optimize) @Outdoctrination]

Cortisol was completely stopped under stress with a simple & cheap supplement, according to a fascinating study.

(🧵1/7)

[gaezv @gaezpeat]

Re-stocked on benfotiamine doing upto 600-900mg/day

- Blocks AGEs
- Prevents vascular leakage and nerve death
- Helps stopping systemic inflammation
- Higher Plasma Thiamine
- Restores Pyruvate Dehydrogenase function
- Blocks VEGF (protect eye/kidney)
- Overall metabolic boost