Fromme Lab

We study how cells sort important stuff around their insides and to their outsides | Golgi aficionados | @Cornell & @CornellMBG | Tweets by lab members

[Fromme Lab @Fromme_Lab]

Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @ryan_vignogna about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!

[Ryan Vignogna @ryan_vignogna]

Mind the GAP 🚧🕳️🚧
Excited to share the latest preprint from the @Fromme_Lab showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵:
https://t.co/VAXCKrEgyW

[Dr. Liz Miller @LizMillerCU]

Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, @jmaldutyte, sleuthed it out.

https://t.co/WN1cVceheh

[Fromme Lab @Fromme_Lab]

created by the multi-talented @ryan_vignogna

[Fromme Lab @Fromme_Lab]

Happy Halloween!
#GhostlyGolgi

[Fromme Lab @Fromme_Lab]

Awesome new paper from @Fran_Bottanelli lab!

[Cell Biology J-Club @cell_club]

ARF1 compartments direct cargo flow via maturation into recycling endosomes
https://t.co/jMmEqSh0rl

[Columbia Medicine @ColumbiaMed]

Columbia will award the 2024 Louisa Gross Horwitz Prize to Scott Emr and Wesley Sundquist for discovering the ESCRT pathway and revealing how it works.

Read more: https://t.co/fhrzLJhVU7

[Cornell MBG @CornellMBG]

Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute.
Please share and apply!
https://t.co/2I7vUskmFF

[Marcus Smolka @MarcusSmolka]

New preprint. More on non-canonical motifs for DDR kinases.

Here we find that Tel1 (yeast ATM) targets D/E-S/T.
... more prevalent than S/T-Q
... NOT shared with Mec1.
May explain how Tel1 plays specialized roles in DNA repair and telomere maintenance.

https://t.co/GyEbwxyddh

[Fromme Lab @Fromme_Lab]

Big congratulations to @ryan_vignogna on his NIH F32 Postdoctoral Fellowship award!!!

[Ryan Vignogna @ryan_vignogna]

F32 NOA ✔️
Very grateful for mentors @jcfromme & @gregoryianlang and thankful to work in such an awesome place @weillinstitute @Fromme_Lab

[Jeremy Baskin @basktastic]

Final version of our latest Kramer story is out! Congrats to @Hongyan_S for leading this effort & Adnan, Dylan, Alessandro, & @nicobuchon too! Read on to learn how Wnt signaling in surprisingly many cell types promotes stem cell proliferation in the gut: https://t.co/Z2OUo8jzAA

[Fromme Lab @Fromme_Lab]

Super impressive membrane-bound Arf1-AP3 cryoEM structures from the Baker lab!🤩

[Rick Baker @therickybaker]

Check out the latest work from my lab, courtesy of soon-to-be Dr. @Biochem_Batman , who determined multiple #cryoEM structures of the human AP-3 adaptor complex. This was a years-long effort to reconstitute active Arf1-AP3 complexes on lipid nanodiscs https://t.co/JgQ3VOAGe3

[Fromme Lab @Fromme_Lab]

lab alum @FeathersRyan is a DRaGoN master

[Ellen Zhong @ZhongingAlong]

Dream team Rish and @FeathersRyan giving a cryoDRGN❄️🐉 lecture and tutorial at #CryoNet in Stockholm! 🤩

[〰Gunther Hollopeter @guntherwho]

Happy to share the newest preprint from @HollopeterLab @cornellvet: https://t.co/GCVafrHneu. We propose the Inversin complex works via a dimerization mechanism. You’re probably thinking, “What the $%@! is the Inversin complex?” Let me explain:

[Ryan Feathers @FeathersRyan]

I'm so excited to finally share the results of my PhD work! Check out this thread for all of the highlights!

Ric1-Rgp1-Rab6 has been the most difficult #cryoEM project I've worked on so far, but I'm so happy with how it came together and what we learned about Rab6 activation!

[Fromme Lab @Fromme_Lab]

@cryomariena Thank you, Mariena!!

[Fromme Lab @Fromme_Lab]

@therickybaker @FeathersRyan Thank you, Rick!!

[Fromme Lab @Fromme_Lab]

@peiferlabunc Thank you, Mark!!

[Fromme Lab @Fromme_Lab]

Fittingly, the URL for the new AlphaFold3 server is:

https://t.co/SlrWl0hoCN

#GolgiTime

*apparently it also works for proteins that do not localize to the Golgi, although we don't know why anyone would use it that way

[Demis Hassabis @demishassabis]

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial https://t.co/Gs4GoOB3fD

[Fromme Lab @Fromme_Lab]

@brettcollins100 @FeathersRyan Thanks very much, Brett!!!

[Fromme Lab @Fromme_Lab]

@ryan_vignogna provided important contributions after @FeathersRyan started his postdoc training with @ZhongingAlong and @HughsonLab. We are grateful for help from @cryomariena and @ktspoth with #cryoEM data collection. #GolgiTime (9/9)
bioRxiv: https://t.co/VpvOpejMwx

[Fromme Lab @Fromme_Lab]

We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)

[Fromme Lab @Fromme_Lab]

Taken together, our findings allow us to model the orientation of Ric1-Rgp1 on the Golgi membrane and understand how it activates Rab6. (8/9)