Jay Gertz

Shameless promotion of our amazing gene regulation/cancer epigenetics work

[Fangyuan (Chelsea) Chen, MD @chelseachenmd]

Glad to share our latest work on The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer models, now published in @Nature_NPJ #npjBCancer, https://t.co/ghzoGAvuS9, with the super-multifunctional browser https://t.co/hSILWd7sAj

[Xiaoyang Zhang @xyzxiaoyang]

We thank NCI for supporting our work in 3D cancer genomics! This work was led by our grad student Katie Mortenson, co-supervised by K-T Varley, with close collaborations from Yang Liu, @GertzLab , and @Sven_Bailey.

[Jay Gertz @GertzLab]

@biorxivpreprint @tweeterginley @CraigRushPhD @xyzxiaoyang We also found that promoters of estrogen up-regulated genes loop together. CRISPRi of a set of 3 promoters uncovered cooperativity between the promoters. Overall, chromatin loop analysis uncovered interesting patterns; but it is not the full story of ER-based gene regulation

[Jay Gertz @GertzLab]

@biorxivpreprint @tweeterginley @CraigRushPhD @xyzxiaoyang We thought that ER bound sites with differential loops would be more important than other ER bound sites. But after using CRISPRi to target 24 regions, the effect was subtle and not significant. Therefore, looping changes are not required for an ER bound site to be functional 3/

[Sean Fanning @DrFanning]

Our latest Review is live! Thanks to ⁦@GertzLab⁩ and ⁦@RMJesel⁩ for your help and ⁦⁦@EndoSocJournals for publishing⁩! https://t.co/vZI0sJ1gar

[Dana-Farber’s Breast Oncology Center @DFCI_BreastOnc]

This excellent review on estrogen receptor alpha mutations, truncations, heterodimers, and therapies, goes into the history of ERα, current research unlocking unknown aspects of ERα signaling, and future directions of ESR1 investigation @RMJesel @GertzLab
https://t.co/16TTxTBI9m

[Jay Gertz @GertzLab]

Our work on how enhancers impact estrogen transcription timing and noise is now out in @CellGenomics! Thanks to everyone that helped out on this project! https://t.co/1JrlEoQdTv @tweeterginley @xyzxiaoyang

[Jay Gertz @GertzLab]

The latest @GertzLab preprint was just posted. It was a great group effort led by @tweeterginley with help from @xyzxiaoyang lab and John Lis’ lab. In this study, we explored how regulatory elements influence gene expression timing and noise in response to estrogen 1/

[Sean Fanning @DrFanning]

Our latest review article on estrogen receptor targeted therapies in breast cancer has been published! https://t.co/TA7PtJ1mTG

[Kristy A. Brown, PhD @BrownLab_KUMC]

We are recruiting!
Time to recirculate this work since there’s still so much to do. If you have expertise in DNA damage repair #DDR and are looking for a postdoctoral position where you can lead clinically-relevant discoveries, please don’t hesitate to reach out. @KUMedCenter

[Jay Gertz @GertzLab]

@gdstormo @generegulation Congratulations!! Thanks for being a great role model and thesis committee member!

[Jay Gertz @GertzLab]

@aaronquinlan Nice! Although I prefer later vintage WS champion Wade Boggs on horseback

[Jay Gertz @GertzLab]

@NeliMUlrich @AlanaWelm @huntsmancancer @BryanWelm @HolmenSheri Thanks Neli!

[Huntsman Cancer Institute @huntsmancancer]

This week is National #PostdocAppreciationWeek. Zannel Blanchard, PhD (@xedbee) is a postdoctoral fellow in the Welm lab. She explains the role of a postdoc, what inspired her to become a cancer researcher, and why she loves working here. #HCIproud

[Jay Gertz @GertzLab]

@aaronquinlan @goosetheband Yeah, it was a great show!

[Damir Varešlija @damirvareslija]

Want to work in the heart of Dublin where cutting-edge research meets a super friendly lab environment? 🍀 Dive into the world of breast cancer brain metastasis with us. Dublin’s warmth and our team’s camaraderie await you! Apply now:

https://t.co/TyuxbAHGUY

[Huntsman Cancer Institute @huntsmancancer]

Endometrial cancer is the most common gynecological cancer and high levels of estrogen promote its development. Researchers at HCI, led by @xedbee and @GertzLab, have identified potential new treatment options for people with endometrial cancer. https://t.co/IvkwCF6e8w

[Jay Gertz @GertzLab]

@ramgar29b @NeliMUlrich @VarleyLab Great to see you and great photos!

[Carlo Palmieri @cancermedic]

My pleasure to have officiated the Gordon Conference Hormone Dependent Cancers 2023 Breast Vs Prostate Football Match. The breast team emerged happy & victorious 4-2 🏆🍾 @MagnaniLab_ICR @oesterreichs @DanielFrigo @damirvareslija @dralexswarbrick @drmcrl @BevanLab @scottdehm