Xuan Li_Lab

Prof Xuan Li (BHF Senior Research Fellow) research group is based at the Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, UK

[Ping Ong MD PhD @laypingong1]

👀 We are recruiting for a Research Assistant to work on novel therapeutics to mend the broken heart❤️‍🩹with stem cells🧫, RNA 🧬Come join us in fun, collaborative, interdisciplinary environment! 🧑🏻‍🔬👩‍⚕️👩🏻‍🔬 @DrCathyWilson @UnivCamPharm @Cambridgecardio @SCICambridge @HLRI_Cambridge

[British Society for Cardiovascular Research @BSCResearch]

Only 3 weeks left to submit abstracts for our ECR symposium in Sheffield on 26th April!

Head here for details and to submit your abstract:

https://t.co/X2ZcWUrbkN

[Murray Clarke Lab @MurrayClarkeLab]

Little News and Views @GroupXuan and I wrote.
Still disappointed they didn't let us use the pun-tastic:

You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help.

https://t.co/VT8yUrSZgP

[Xuan Li_Lab @GroupXuan]

👉https://t.co/ii33q7n8s6

[Xuan Li_Lab @GroupXuan]

Our( with @MurrayClarkeLab ) News & Views (https://t.co/ii33q7n8s6) for @NatureCVR research article https://t.co/K5EpsgVqon

[Xuan Li_Lab @GroupXuan]

Pleased to see our study is highlighted as the Editor's pick in JCI This Month. https://t.co/vjAFfsU6KI
https://t.co/EhoDKftOAt
Thanks to @TheBHF

[Xuan Li_Lab @GroupXuan]

@antongistera @josejfuster @lassefolkersen @Hagberglab @antongistera thanks for all the organizers for your invitation. Broadly-covered research topics & great interactions & beautiful scene!

[Anton Gisterå @antongistera]

Karolinska Cardiovascular Research Retreat 2023. Thanks @josejfuster @GroupXuan @lassefolkersen @Hagberglab and all participants. 🫀

[Atherosclerosis @ATHjournal]

VSMCs are efficient activators of IL-1β that do not use canonical inflammasomes or caspases. Hence, this alternative pathway could be targeted for long-term treatment of CVDs, as it is not central to everyday host defence
@MurrayClarkeLab @society_eas
🔗https://t.co/szQPdpA6Nr

[Nature Cardiovascular Research @NatureCVR]

N&V by @Prosser_Lab on the recent study by
@C_M_Loescher, Johanna K. Freundt et al. pinpointing the contributors to #myocardial passive #stiffness. @PennMedicine|https://t.co/FL7TRz2y8y

👉https://t.co/AGdCxfhwUn

[nature @Nature]

Nature research paper: IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer https://t.co/TTfogxGjO3

[Marta Baldrighi @m_baldri]

PoV: your main PhD paper is finally published but the Uni's comms office decides that your cell biology and immunology research is best represented by a *big ugly foot* 👣

Still super proud, though. Great team effort @GroupXuan

https://t.co/GEo92vbGIq

[Xuan Li_Lab @GroupXuan]

@m_baldri 🥳&😂

[Xuan Li_Lab @GroupXuan]

This cover image for our research article https://t.co/vjAFfsU6KI shows inflammatory macrophages with many NLRP3 signals (green) around the microtubule-organizing centre (microtubules in red). Taken by Yang Li & @chenxiao027 using Zeiss LSM980 with airyscan 2 @zeiss_micro

[Xuan Li_Lab @GroupXuan]

We show targeting microtubules via pharmacological drugs to inhibit PLK1 could provide a treatment strategy for inflammatory diseases characterized by excessive NLRP3 activation. https://t.co/i5fk7SssIb

[Medical Xpress @medical_xpress]

Cancer drug could hold hope for treating #inflammatoryDiseases including gout and heart diseases @Cambridge_Uni @jclinicalinvest https://t.co/yWUBLCDWpL https://t.co/7tqQcPelZ8

[Xuan Li_Lab @GroupXuan]

Check our paper published at JCI, featured as cover for this issue. Brilliant team members (@m_baldri Christain Doreth Yang Li @DrEmilyFW …) and collaborators (@zxh1121 @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat…) for this collective effort. Thanks to @TheBHF .

[Journal of Clinical Investigation @jclinicalinvest]

#Cover: PLK1 regulates NLRP3 inflammasome activation by controlling microtubule organization: https://t.co/auN4z0gUHh

@GroupXuan @m_baldri @zxh1121 @DrEmilyFW @MurrayClarkeLab @GdC_CCCB_lab @m_malumbres @ZMallat

#CellBiology #Immunology

[Michael @MichaelLee04]

Labeling bio images just got 10x faster 🏎️

Watch our best AI model yet in action, released today as AI Detect on @BiodockAI.

You prompt one object, it finds the rest. Try it for free now!

[Takashi Ochi @dr_takashi_ochi]

CAPture, a centrosome affinity purification method for mammalian cells, is finally out🥳 https://t.co/0egCHFd91W

We found that a short peptide of CCDC61/VFL3 can be used to isolate centrosomes / basal bodies cell lysates