Ben Prosser

Assoc. Prof @PennMedicine | Rare-disease dad. Trying to fix hearts AND brains. Myocytes, Microtubules, Heart Failure | ASOs, RNA, NeuroDevelopmental Disorders.

[Ben Prosser @Prosser_Lab]

What a privilege to have the team and opportunity to try and help my daughter and those like her live healthier, fuller lives. We will be a relentless force for good against #RareDisease.
@IngoHelbig @lab_davidson @ChildrensPhila @PennMedicine https://t.co/WkNHxn7XTc

[ZEISS Group @ZEISS_Group]

Prof. Benjamin L. Prosser and his team at the @Prosser_Lab at @PennMedicine are researching the heart on a molecular level. Learn more about how his personal story motivated him to work on transformative cardiac and gene research.
Visit https://t.co/IeOEPY0z95
#Health

[Circulation Research @CircRes]

@LucieCarrier84 lab provide evidence that targeting #tubulin #tyrosination could be a novel approach for improving heart function in patients with #HCM. Learn more at https://t.co/6FzAYF4rXO

@Prosser_Lab @mcaporizzo @CyxChristina @dirkwestermann @LucasBacmeister

[Rikke S. Møller @FiladelfiaGene1]

This study, conducted in close collaboration with @curestxbp1, aimed to identify the rate & causes of early mortality in #STXBP1-related disorders.

These results are important for family & prognostic counselling💜

@FrancescaFuria_ @Elegardella 👏

https://t.co/8WqyAWJqTg

[Ben Prosser @Prosser_Lab]

$$$ for #RareDisease research!
RFAs for 35 different rare disorders through the @ODC_UPenn, including 2 x $70K grants available to @curestxbp1 courtesy of Lulu's Crew :)

Info and app link here: https://t.co/agZMdLsrGr

[Science Translational Medicine @ScienceTM]

Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser https://t.co/pfvLktEr6T

[Ben Prosser @Prosser_Lab]

Want to know more about what ENDD is doing for rare 🧠disorders like @cureSYNGAP1 and @curestxbp1?

Updated website here! https://t.co/LwbLZe0v6V

@ChildrensPhila @PennMedicine @lab_davidson @IngoHelbig @EAHellerPhD

[Ben Prosser @Prosser_Lab]

@Chris_W_Ward @ScienceTM @MarguliesLab Cool! Is it out in press, or what’s our ETA? Please share when available!

[Ben Prosser @Prosser_Lab]

Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab

1/5

https://t.co/gtcpuo7dFI

[Ben Prosser @Prosser_Lab]

@HesselAnthony @tweetineaton @MCaporizzo Indeed - and now with a small molecule we can run the experiment! An additional interesting question with this approach is even if stiffness course corrects, might we still speed relaxation (and how much functional benefit will that confer)?

[Ben Prosser @Prosser_Lab]

Next big step - determine chronic efficacy (and safety!) with sustained treatment to prevent progression of HFpEF (and other forms of HF). Awesome effort from @tweetineaton @MCaporizzo and Ben Lee.

[Ben Prosser @Prosser_Lab]

In vivo, overnight VASHi was well tolerated, and improved ventricular relaxation and diastolic function in advanced HFpEF. (opinion - that's pretty cool for just targeting a microtubule PTM!) 4/5

[Leslie K. 👩🏾‍🔬 @Heart4Carolina]

@Prosser_Lab @Rongtian2
The traditional #GRC soccer game ⚽️ 🥅

#GRCcardiac2024
#CardiacRegMechanisms
#ColbySawyerCollege

[Kehat Lab @KehatLab]

Check out our new paper @jclinicalinvest by the great @Ramihdd and @shkedio. We show that the protein RPSA is required for ribosome localization, localized translation, and the maintenance of the sarcomere. https://t.co/C23OfsbxaW

[Ben Prosser @Prosser_Lab]

Happy birthday Lu!
6 years - and now standing by yourself!
I have too many feelings to tweet, so I'll just say THANK YOU to everyone who has supported Lucy, or who is fighting to improve the lives of those with #raredisease. Keep going.

[Ben Prosser @Prosser_Lab]

@bomba_ewa @UPennPhysiology @PennMedicine Yeah!! We’re so pumped for you to join us!

[Ben Prosser @Prosser_Lab]

Keep going Brett.

[Brett @ UFD Tech @UFDTech]

Someone asked me about the scratches I had on my faces during a recent video. Living life trying to @cureSYNGAP1 isn't always easy, but Emmitt's always worth it.

[Ben Prosser @Prosser_Lab]

Don't miss the premier conference for fundamental and translational cardiac research! Program in link, still with open talk slots to be selected from abstracts.
#CardioTwitter @Rongtian2 @KimHellgren @Heart4Carolina
https://t.co/3aUr2tpXkl

[Ben Prosser @Prosser_Lab]

These are BEAUTIFUL 👏tissue mechanics in living myocardial slices by the Caporizzo Lab. They define (with precision) how targeting microtubules can improve cardiac function by facilitating relaxation and early diastolic filling.

[Matt Caporizzo @MCaporizzo]

Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible!
https://t.co/wb2o6q8wPT