In KETO-HFpEF, we integrated CPET, echo, lung US, tonometry, metabolites, isotope tracer, & leg MRI. Ketone ester didn't ⬆️ exercise, despite ⬇️filling pressure & glucose use at rest/exercise
Simpub #ACC25#JACCHF
🙏 #PZamani@MarguliesLab &team
@PennCardiology@DukeHeartCenter
The @STS_CTsurgery has awarded @mikeibrahimmd 🩺 funding to research t-tubule remodeling in the cardiac muscle cells of people w/ #heartfailure.
This is the 1st time the award 🏆 has been granted to a cardiothoracic surgeon.
Learn more ⬇️ https://t.co/SyX3CaUu4h
We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! https://t.co/EAaKaI104X
Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab@Prosser https://t.co/pfvLktEr6T
Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab
1/5
https://t.co/gtcpuo7dFI
A new study by @Prosser_Lab and @MarguliesLab found that inhibiting vasohibin reduced heart muscle stiffness. This could lead to new treatments for heart failure with preserved ejection fraction (HFpEF) https://t.co/MySwzQhN6X
Congratulations to lab member/Research Assistant Professor @AlexiaVite93 on being awarded both (!!) the AHA CDA and Second Century Early Faculty Independence Award!
Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible!
https://t.co/wb2o6q8wPT
In our new study led by @NesrineBouhrira , we explore how rapid induction of stiffness-induced mechanical memory in cardiomyocytes suggests potential interventions for maladaptive myocardial stiffening @BasicResCardiol@AlexiaVite93 https://t.co/8MQJ4lGV6r
Using #cardiomyocytes from failing hearts, @MarguliesLab found that these cells exhibit metabolic inflexibility, relying on non-carbohydrate sources for contractility.
Read the new #JACCBTS study by @AlexiaVite93, et al here: https://t.co/pw7WJWBDQG