Margulies Lab

Translational research lab at @PennCVI @PennMedicine studying heart failure

[Margulies Lab @MarguliesLab]

Welcome to the Margulies Lab twitter! We’re excited to be here and share all things heart related 🫀

[Senthil Selvaraj, MD, MS, MA @senthil_selv]

In KETO-HFpEF, we integrated CPET, echo, lung US, tonometry, metabolites, isotope tracer, & leg MRI. Ketone ester didn't ⬆️ exercise, despite ⬇️filling pressure & glucose use at rest/exercise
Simpub #ACC25 #JACCHF
🙏 #PZamani @MarguliesLab &team
@PennCardiology @DukeHeartCenter

[@BMES_CMBE @BMES_CMBE]

From monocytes pulling matrix by @KoladeAdebowal1 to cardiac in vitro models by Benjamin Lee from @MarguliesLab we continue the mechanobiofun at #cmbes2025 @ucsdbe @PennMedicine @PennCVI @UCSDJacobs

[Senthil Selvaraj, MD, MS, MA @senthil_selv]

Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i

Simpub #AHA24 & @JACCJournals #JACCBTS
https://t.co/iIR6V17X3i

🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team

@DukeHeartCenter @DukeMPI

[PennCVI @PennCVI]

CVI's Highlighted #PapersoftheWeek
@BaurLab
@DanKellyPennCVI
https://t.co/A36kvH0iZJ

[Margulies Lab @MarguliesLab]

Congratulations @mikeibrahimmd !!

[Penn Heart & Vascular @PennCardiology]

The @STS_CTsurgery has awarded @mikeibrahimmd 🩺 funding to research t-tubule remodeling in the cardiac muscle cells of people w/ #heartfailure.

This is the 1st time the award 🏆 has been granted to a cardiothoracic surgeon.

Learn more ⬇️ https://t.co/SyX3CaUu4h

[Margulies Lab @MarguliesLab]

Congratulations to @AlexiaVite93 on placing in the Lightening Talk competition at @ISHR_NAS meeting in Long Beach, CA

[PennCVI @PennCVI]

CVI's Highlighted #PapersoftheWeek https://t.co/itDkQQtBJ4

[The Arany lab @AranyLab]

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! https://t.co/EAaKaI104X

[Science Translational Medicine @ScienceTM]

Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser https://t.co/pfvLktEr6T

[Ben Prosser @Prosser_Lab]

Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab

1/5

https://t.co/gtcpuo7dFI

[Penn Medicine @PennMedicine]

A new study by @Prosser_Lab and @MarguliesLab found that inhibiting vasohibin reduced heart muscle stiffness. This could lead to new treatments for heart failure with preserved ejection fraction (HFpEF) https://t.co/MySwzQhN6X

[PennCVI @PennCVI]

Congratulations Alexia Vite! Awarded the American Heart Association’s Career Development Award and the Second Century Early Faculty Independence Award

[PennCVI @PennCVI]

CVI’s Highlighted #PapersoftheWeek https://t.co/s7IhOq1AR7

[Margulies Lab @MarguliesLab]

Congratulations to lab member/Research Assistant Professor @AlexiaVite93 on being awarded both (!!) the AHA CDA and Second Century Early Faculty Independence Award!

[Matt Caporizzo @MCaporizzo]

Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible!
https://t.co/wb2o6q8wPT

[Penn Medicine CSO @PennMedCSO]

New research examines the functional impact of alternative metabolic substrates in failing human cardiomyocytes ft. @AlexiaVite93, Timothy Matsuura, @kbedi88, Emily Flam, @AranyLab, @DanKellyPennCVI & @MarguliesLab (@PennCVI/ @PennCardiology) https://t.co/dcItU0LTnS

[Basic Research in Cardiology @BasicResCardiol]

Mechanical memory of human iPS-derived fibroblasts and cardiomyocytes.
https://t.co/WsQIAUvstf

[Margulies Lab @MarguliesLab]

In our new study led by @NesrineBouhrira , we explore how rapid induction of stiffness-induced mechanical memory in cardiomyocytes suggests potential interventions for maladaptive myocardial stiffening @BasicResCardiol @AlexiaVite93 https://t.co/8MQJ4lGV6r

[PennCVI @PennCVI]

Congratulations Benjamin Lee! Received the American Society for Clinical Investigation's Emerging-Generation Award

[JACC Journals @JACCJournals]

Using #cardiomyocytes from failing hearts, @MarguliesLab found that these cells exhibit metabolic inflexibility, relying on non-carbohydrate sources for contractility.

Read the new #JACCBTS study by @AlexiaVite93, et al here: https://t.co/pw7WJWBDQG