Andrew Earl

PhD Candidate in Buenrostro Lab @Harvard | @BYU alum | single cell genomics, chromatin biology, gene regulation

[Dawn Chen @dawnchenx]

Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine!

We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks.

https://t.co/2h7Skln60Q

[Ajay Labade @ajaylabade31]

Unveiling Expansion in situ genome sequencing: a revolutionary leap in spatial genomics! ExIGS enables simultaneous nanoscale mapping of gDNA and proteins in single cells.
It's been an incredible journey co-leading this work with @z_chiang , @CarolineComenho , @JD_Buenrostro

[Caroline Comenho @CarolineComenho]

So excited to finally share ExIGS, a new tech we (@z_chiang @ajaylabade31 @JD_Buenrostro) developed to combine spatial genomics with expansion microscopy

[zack chiang @z_chiang]

7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies

Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing

1/

[Tristan Tay @TristanTay1]

T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this gap (https://t.co/BRC1tAHaWU):

[Andrew Earl @H3K4me1]

@MelsNeurons @NikonSmallWorld So cool! 🤩 Congrats!

[Sarah Mangiameli @s_mangiameli]

Photoselective Sequencing is out in @naturemethods! This was a collaborative effort between the @insitubiology and @JD_Buenrostro labs, and I couldn't have done it without my co-authors @haiqi_chen, @H3K4me1 ,@juliedobkin_ , and @DLesman!

https://t.co/Sj5D93zW6m

[Andrew Earl @H3K4me1]

PRINT is an amazing computational tool by @YanHu41082612 that can reveal all kinds of novel insights from scATAC-seq data.

[Yan Hu @YanHu41082612]

Single-cell ATAC-seq finds active regulatory elements across cell types, but its resolution can be limited. What if we could identify when and where proteins bind to chromatin?

Introducing PRINT, a new single-cell footprinting tool from @JD_Buenrostro lab
https://t.co/nX1UUYNQcJ

[Andrew Earl @H3K4me1]

Super exciting preprint from @s_mangiameli describing a method for spatial genomic measurements!

[Sarah Mangiameli @s_mangiameli]

Sharing Photoselective Sequencing (PSS), a new method for genomic and epigenomic measurements within spatial regions of interest.

Thanks to the whole team @haiqi_chen, @H3K4me1, @juliedobkin_, @DLesman, @JD_Buenrostro, and Fei Chen.

https://t.co/N2UrSGoPtQ

(1/9).

[Vinay Kartha @vkartha88]

Excited to share some of my postdoc work surrounding the development of a computational framework to help derive gene regulatory networks, which we apply to determine drivers of immunogenic response in blood, officially out in @CellGenomics!

https://t.co/nYrCzNhJqn

[zack chiang @z_chiang]

Some personal news, I'm defending my PhD next week!

To wrap up my thoughts, I wrote about why you should work on tech dev and the future of spatial genomics 🧬🔬

https://t.co/zXLpUlNMPk

[Rachel Savage @Rachel_E_Savage]

Ever wonder how normal cells “climb the ladder” of epigenetic and genetic aberrations to become cancerous?
Really excited to share the review on single-cell cancer epigenomics I had the pleasure of writing with @Lindsay_LaFave and @JD_Buenrostro! https://t.co/VXkLRIg5nw

[Andrew Earl @H3K4me1]

Congrats, Sai! I'm excited for all the great science that will come from the Ma Lab! 🤩

[Sai Ma @saima_lab]

I am thrilled to announce that I will start my lab as an Assistant Professor in the Department of Genetics and Genomic Sciences @SinaiGenetics at Mount Sinai @IcahnMountSinai and a member of Icahn Genomics Institute @IcahnInstitute this fall!

[J Cell Science @J_Cell_Sci]

Check out our 'First persons' interview with Ajay Labade @ajaylabade31 @HSCRB and Adwait Salvi @Adwaitforit1 @FMIscience on their joint project @IISERPune investigating the role of genome organization in gene regulation during differentiation: https://t.co/875ira1hFE

[zack chiang @z_chiang]

Just released @Nature: slide-DNA-seq, our new method for spatial DNA sequencing in tissues 🧬

Excited to add a genetic dimension to the rapidly expanding spatial toolbox with the tech dev superteam of Tongtong Zhao, @JD_Buenrostro & @insitubiology (1/6)

https://t.co/Au1Fe0tOpf

[Nature Biotechnology @NatureBiotech]

To celebrate #HispanicHeritageMonth we highlight outstanding researchers in the US. Today we recognize Harvard's Jason Buenrostro, whose lab uses single-cell tools to understand cell variation, cellular decisions and how transcription factors affect regulatory element activity

[Eric Greer Lab @EricGreerLab]

Excited to share a preprint that has been quite a few yrs in the making! We track heritable epigenetic info for the 1st time and show that methylation of the 18S rRNA is passed from parents to kids to set up altered translation 1/13 https://t.co/Puo27nfEGP

[Andrew Earl @H3K4me1]

Congrats to @vkartha88! An awesome tool to "FigR" out gene regulatory relationships.

[Vinay Kartha @vkartha88]

Excited to share a preprint describing a workflow to infer chromatin-mediated regulation of gene expression using single cell data, which we applied using multi-omics of resting and stimulated human blood cells! Some highlights 🧵: 1/

[Sai Ma @saima_lab]

Interested in single-cell multi-omics? Check out our step-by-step SHARE-seq protocol for paired ATAC-RNA profiling! https://t.co/DstQKLjaxg

[Active Motif @activemotif]

NEW @epigenetics_pod! @JD_Buenrostro from @Harvard talks about a serendipitous discovery in the lab that led to the development of the ATAC-Seq method. Quite a story! Listen now: https://t.co/H7Ji1CSZtN