Spotlight: The first to establish alanine metabolism as a potential therapeutic target for fibrotic diseases👇
https://t.co/Q9KokgKa6K
William M. Oldham @wm_oldham & team @BrownMedicine report scar-forming cells in #PulmonaryFibrosis rely on alanine as a metabolic building block and simultaneously blocking its synthesis and uptake suppresses #fibrosis in human lung tissue.
The images: Markers of myofibroblast differentiation (α-SMA and COL1A1) in IPF patient-derived cells under conditions of TGF-β stimulation (1/2) and impaired alanine metabolism (2/2).
with @EdyKim5
Spatial transcriptomics of the developing mouse brain immune landscape reveals effects of maternal immune activation and microbiome depletion.
https://t.co/eGz8eLJW4b
Progressive Fibrosis in Human MASLD is Associated with Spatially Linked Transcriptomic Signatures of Metabolic Reprogramming and Senescence - JHEP Reports https://t.co/7BTxfQfVIf
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice @GeroScienceAGE https://t.co/fjvHRC43NO