Marcus Hartmann

Structural Biochemistry @MPI_Bio & @UNI_TUE
Understanding and Manipulating Molecular Machines

[Marcus Hartmann @HartmannLab]

1/4 Very happy to share the short history about how we discovered a natural #degron of #cereblon @BBRCME.

We show how #CRBN specifically recognizes C-terminal cyclic imides as protein damage markers.

Shout-out to Chris @NanoTemper & the Schwarzer group!

https://t.co/enY63gsJZ7

[Hakim @hakim034]

Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome!

[Mohammad ElGamacy @m_elgamacy]

We just released the "protein design toolkit", integrating tools from Damietta, ProteinMPNN and OpenMM.

An interactive tutorial is available at the server https://t.co/gmoCK0BbfV. Recommended usage is described in the paper: https://t.co/Uxghy5MO1U and feedback is most welcome!

[Marcus Hartmann @HartmannLab]

Check out our optimized natural #CRBN degron inspired #PROTACs!

[Max Planck Society @maxplanckpress]

😁🎉😄🌟#NobelPrize!🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃😊🏆😁#PhysicsNobelPrize2023 for Ferenc Krausz, Max Planck Institute of Quantum Optics! 🎊😃🥰😆🥳😁😃🎉🏅😊🎈😁🥳😄🎊😁🌟😃🥰🏆😁🎉🎇😊🥳😄🌟🎈😁😃🥰🎉🏆😁🎊😊😄🥳🌟🎇😁🥰😃🎉🎈😁🏆😊😄🎊🥳😁🌟😃🥰🎉🏅😁🎈😊🥳😄🎉😁😍😁🎉🎇😊🥳😄🌟🎈🏆

[Marcus Hartmann @HartmannLab]

Sleeves up for infection research:
Our postdoc Joe Joiner researches anti-infectives to prevent #Salmonella infection. He’s not only appreciated as a talented researcher, but also as a great teacher by his students!

@PAW_Germany #PostDocAppreciationWeek @MPI_Bio

[Khaled A. Selim @Selim_Khaled_]

A press release about our recent paper in @PNASNews

https://t.co/VKkgJ9ains

Cyanobacterial protein integrates the circadian clock information
https://t.co/AUtTx5UvRi via @growkudos @uni_tue_exstra @CoE_CMFI @MPI_Bio

[Vikram Alva @Vikram_Alva]

Fun fact: At 1.06 Å, this is the first-ever structure of any histone protein determined at atomic resolution - for what it's worth! 🤣

https://t.co/sx2mrB0KJo

[Vikram Alva @Vikram_Alva]

Congrats, truly seminal work! Since our initial discovery of bacterial histones, we too worked on the very same histone protein & now present its crystal structure & DNA-binding properties. Great work by Yimin, Birte & collaborators @HartmannLab @MPI_Bio

https://t.co/sx2mrB0KJo

[Ingo Hartung @HartungIngo]

An excellent perspective by authors from @AstraZeneca about fragment-based approaches to identify ligands for E3 ligases. Of especially high relevance for the field of targeted protein degradation (#TPD). @ACSBioMed https://t.co/5lRasDVD5T

[Marcus Hartmann @HartmannLab]

Check out our work on regulating #Salmonella virulence @biorxivpreprint!

Great job by Joe, Wieland, Thales, @BangeBalcony, @atposo & @samuwag:

HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids. https://t.co/NO14taX8tC

[Khaled A. Selim @Selim_Khaled_]

After long time in oven, happy to share w/ @HartmannLab @PNASNews
our work #Cyanobacteria #Carbon #Sensor SbtB possesses atypical #Redox regulated #Apyrase (hydrolysing ATP/ADP) to control HCO3 transport

Generous fund by @uni_tue_exstra @CoE_CMFI @MPI_Bio
https://t.co/VKkgJ9ains

[Marcus Hartmann @HartmannLab]

Happy to share the missing link between the action of #IMiDs & #CELMoDs and the natural #CRBN degron @BBRCME:

Neo-substrates mimic every single H-bond of cyclic imide #degron recognition, inevitably inheriting sequence-independence of natural #degrons
👇
https://t.co/VE9YbHe5yx

[Marcus Hartmann @HartmannLab]

@KylieAllenVT @FEBS_Letters Congrats, very nice story!

[Guillaume Laconde @Glaconde34]

Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines https://t.co/niTRp2nIJT

[Marcus Hartmann @HartmannLab]

🥳🥳 Congrats, great job! 🥳🥳

Fantastic PhD defense by Joe this week, showcasing great results from your collaborative salmonella anti-virulence project with @samuwag @atposo @BronstrupLab!

#Salmonella, beware of Joe! @phd_reps_MPI_DB

[Marcus Hartmann @HartmannLab]

We couldn't agree more - this is a fascinating topic and we are more than happy to provide the structural basis for the recognition of the C-terminal cyclic imide #degron in our new communication @BBRCME:

https://t.co/enY63gbGX7

[Marcus Hartmann @HartmannLab]

4/4 We are more than happy to finally reveal the structural basis 2 years after Chris defended his thesis & finally want to congratulate @drcmwoo, her team & collaborators for their fantastic & very thorough chemical biology work on the same topic @Nature!

#PROTACs #Thalidomide

[Marcus Hartmann @HartmannLab]

1/4 Very happy to share the short history about how we discovered a natural #degron of #cereblon @BBRCME.

We show how #CRBN specifically recognizes C-terminal cyclic imides as protein damage markers.

Shout-out to Chris @NanoTemper & the Schwarzer group!

https://t.co/enY63gsJZ7

[Marcus Hartmann @HartmannLab]

3/4 Strinkingly, the aspartimide degron recognition mode is exactly the same as the one we previously identified for aspartimide based #CELMoDs / #IMiDs @ACSBioMed:

https://t.co/OfajB9ILfr