Ya-Chi Ho

Ho Lab on HIV Persistence, Microbial Pathogenesis, Yale University School of Medicine

[Ya-Chi Ho @HoLabHIV]

@ImmunityCP Single-cell epigenetic, transcriptional & protein profile of latent & active HIV+ cells by DOGMAseq identified 4 states of HIV+ cells: IRF, cytotoxic, AP-1 & cell death. IKZF3 helps HIV+ cells proliferate. Congrats to our postdoc @Yulong_Wei!🎊 https://t.co/cKxg1Ljfc4

[Ya-Chi Ho @HoLabHIV]

Enjoying exciting science and stimulating discussions at CROI 2024! Congrats to our postdoc Michelle for her work on finding HIV reservoir and T cell migration dynamics in the gut and undergrad Sam for his work on HIV-host interactions at the integration site.

[Ya-Chi Ho @HoLabHIV]

@madamscientist @CMM_JHU I can certainly justify it's an outstanding program! :)

[Ya-Chi Ho @HoLabHIV]

HIV tat mRNA-lipid nanoparticle+panobinostat can reactivate HIV+ cells 3X higher than PMA/ionomycin (the strongest HIV latency reversing agent) with minimal effects on the cell transcriptome. Congrats Marion Pardons at Linos Vandekerckhove Lab/Ghent!
https://t.co/oXy35pAR1e

[Ya-Chi Ho @HoLabHIV]

Love to explore how HIV hides in CD4 T cells? Love single-cell multiomics, bioinformatics, genomics, and immunology? Wanna join Michelle and Sam, the freshly minted CROI New Investigator Awardees? About to graduate from PhD? Join our lab as a postdoc now!
https://t.co/q6s3ERr1ey

[Ya-Chi Ho @HoLabHIV]

@LizaKonnikova @ImmunityCP @Yulong_Wei Looking forward to our exciting collaborations (which is *literally* ongoing)! :)

[Ya-Chi Ho @HoLabHIV]

@ImmunityCP Single-cell epigenetic, transcriptional & protein profile of latent & active HIV+ cells by DOGMAseq identified 4 states of HIV+ cells: IRF, cytotoxic, AP-1 & cell death. IKZF3 helps HIV+ cells proliferate. Congrats to our postdoc @Yulong_Wei!🎊 https://t.co/cKxg1Ljfc4

[Ya-Chi Ho @HoLabHIV]

@DeannaKulpa You are too kind Deanna!

[Ya-Chi Ho @HoLabHIV]

@SimonettiFR @ImmunityCP @Yulong_Wei Yours is real Nature! :)

[Ya-Chi Ho @HoLabHIV]

Many thanks to our study participants and study team in the Sabes and Merlin Cohort, led by @DuerrHOPEgroup. Inspired by @vincewu9 @BettsLab @golnaz_v @LauraVella17 . @REACHforthecure @YaleMicroPath @YaleRNA @YaleIBIO

[Ya-Chi Ho @HoLabHIV]

Understanding heterogenous & rare HIV reservoir requires single-cell multiomics. What are ECCITEseq, FINDseq, PhePseq, ASAPseq, DOGMAseq? Why & how? Principles, method & bioinformatic guide reviewed @CO_HIV_AIDS by our postdocs Michelle Wong & @Yulong_Wei
https://t.co/zZxn4psEXq

[Ya-Chi Ho @HoLabHIV]

Beautiful study/must read! @RasmiThomas /MHRP today @ScienceTM: Single-cell multiomics identified restriction factor PTMA. HIV RNA+ cells overexpress cytotoxic markers. PTMA negatively correlate with HIV RNA. PTMA overexpression inhibits HIV transcription. https://t.co/zHKExGbduh

[Ya-Chi Ho @HoLabHIV]

@ProfSharonLewin Thank you @ProfSharonLewin! It's my honor to share our work!!

[Ya-Chi Ho @HoLabHIV]

Contributing to the exciting #IAS2023 meeting by a Plenary talk on "New Approaches to measuring HIV reservoir" with @asiersc @Thumbi_Ndungu. Enjoyed stimulating discussions with colleagues and friends! @DuerrHOPEgroup @ProfSharonLewin @Marinacaskey @AlbertoBosqueP @BettsLab

[Ya-Chi Ho @HoLabHIV]

@katharine_bar Katie Bar @PennCFAR is giving a magnificent Plenary talk on antibodies for HIV cure at #IAS2023. Super clear and informative!

[Ya-Chi Ho @HoLabHIV]

Find & target HIV reservoir, by amazing artist Paco. HIV Science as Art program brings HIV discoveries to life by 12 extraordinary artists living with HIV. On exhibit at MetroArts Brisbane. All funds raised will support community HIV programs & services. https://t.co/VOiauEsVpV

[Ya-Chi Ho @HoLabHIV]

@ProfSharonLewin: #IAS2023 brings together experts from across those spheres to examine the latest advances in research and forge a more equitable & innovative HIV response that puts people first. Feel humbled and excited to talk at the exciting #IAS2023 at Brisbane!

[Sharon Lewin @ProfSharonLewin]

1/5: I'm excited to welcome you to my home country of #Australia for #IAS2023, the 12th IAS Conference on #HIV Science!

The conference officially kicks off tomorrow in #Brisbane and virtually and will run from 23 to 26 July. 🧵 https://t.co/H7P1NxVZfs

[Ya-Chi Ho @HoLabHIV]

@dsgoodsell @dsgoodsell It's all because of your amazing work! I wonder if our paintings count as 10 citations of your work... :)

[Ya-Chi Ho @HoLabHIV]

@c_gaebler @dsgoodsell @AmareEshetu7 @Yulong_Wei @YaleMicroPath @Welcome2theHIVE @YaleRNA This is the closest I can get toward HIV Env structure, about 30,000,000 nm resolution.

[Ya-Chi Ho @HoLabHIV]

Learning HIV life cycle by recapitulating @dsgoodsell's beautiful and evidence-based illustrations in our lab retreat. Discovered impressive talent of our lab members!

[Ya-Chi Ho @HoLabHIV]

@akreuschl Instead of AI simulation, we are trying human simulation... :)