Timothée Bruel

Group Leader Antiviral Activities of Antibodies @Virus_Immunity @institutpasteur - Virology/Immunology - Member @SFV_France - @timotheebruel.bsky.social

[Timothée Bruel @Timothee_B]

1/ 🧵Thrilled to share that our new paper was just published at @ScienceTM @aaas ! 🎉

We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫

https://t.co/3wheB6bJhu

A thread ⬇️

[Aurelie Wiedemann @alili66100]

Cross-reactive antibody and functional T-cell responses to Bundibugyo virus induced by Zaire ebolavirus vaccination and infection
https://t.co/TZs0TVbFpz #Ebola #vaccine #outbreak

[Casanova Lab @casanova_lab]

Type I IFN autoantibodies in three of seven Europeans with life-threatening Usutu virus infection https://t.co/LKH2Un68Hv

[Antigen Evolution and Design lab @AntigenEvo]

Less than two weeks left to apply for a PhD in the lab!

Details and application 👇 👇 👇

[10x Genomics @10xGenomics]

Introducing Sentira Single Cell, a new agentic analysis platform. Explore Chromium data with natural language, refine analyses in editable, reproducible notebooks and stay in control from scientific questions to experimental conclusions: https://t.co/AuHhOymsVp

[Jérémie Le Pen @Jeremie_Le_Pen]

I’m recruiting a Postdoctoral Fellow to join my lab at the Harvard T.H. Chan School of Public Health, working on innate immunity to RNA viruses.

To apply, please email a CV and a letter of interest to [email protected]. Details: https://t.co/rOhOWR9PF6

[Yehlin Cho @ChoYehlin]

🚀 Excited to share BindClaw! 🦀

Starting from a prompt or research paper, BindClaw connects biological mechanisms to protein design: identify targets and binding sites → build mechanism-specific computational assays → generate and assess binders → refine designs using the results.

We use agents to evaluate whether designs fit the intended biological objective, including competition with a native partner and preference for a particular molecular state. 🧬

In a human-guided calmodulin campaign, 15 of 18 designs showed binding to calcium-loaded CaM, including subnanomolar binders supported by both BLI and SPR.

This work is an incredible team effort together with @DidiKieran , @saint__ai, @ Kyle Gion and @sacdallago and many others!

📄paper/project: https://t.co/MkjU6Swke7
💻code: will be released in a few weeks!

[Timothée Bruel @Timothee_B]

@AnthropicAI @amirshanehsaz Forgot to say : amazing initiative 👏👏

[Timothée Bruel @Timothee_B]

@AnthropicAI @amirshanehsaz Please add @institutpasteur !
🙏🙏🙏

[NVIDIA Healthcare @NVIDIAHealth]

🎃 All treats, no tricks.
Run RFD4-Proteina on RTX PRO 6000 GPUs on @huggingface, free until Nov 4. You can design proteins in your browser without installing anything. https://t.co/LpqCd3SNyN

[Karim Majzoub @KarimMajzoub]

Paper alert from our lab in collaboration with Nadine Laguette and Dorothée MISSÉ’s labs. Have you ever heard if Tonate virus? :)
The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus infection https://t.co/1BhnISkk8Y

[Timothée Bruel @Timothee_B]

« For clinical trials, I'd even call human-only review dangerous »

I felt like that AI reviews are reliable and objective as compared to human ones.

Amazing to seer this quantified.

Given the burden of reviewing it raises many interesting question…

[Ruslan Rust @rust_ruslan]

Lots of debate this week on whether journals should ban AI in peer review.

We actually tested this in our new preprint, and the results were pretty clear to me.

For context, I've reviewed for most of the big journals and evaluated 1,000 human reviews as an editor. I love to read and evaluate science.

TLDR: From now on I won't do any peer review without AI. For clinical trials, I'd even call human-only review dangerous 🧵

[Yunlong Richard Cao @yunlong_cao]

Our BA.3.2.2 study is now published in Nature Microbiology!

Counterintuitively, we found that ancestral-strain immune imprinting protects against BA.3.2.2 through IGHV3-53/66 Class 1 antibodies, helping explain why BA.3.2.2 selectively infects children.

https://t.co/M7YKbsA48b

[nature @Nature]

Nature research paper: Structural basis for protocadherin-1 recognition by New World hantaviruses

https://t.co/BzOFIXJloD

[Timothée Bruel @Timothee_B]

What an amazing opportunity !

[Nathan C. Frey @nc_frey]

Today, we’re announcing an open call for guest investigators in life sciences. Over 8–12 weeks, guest investigators will work directly with my team and other Anthropic researchers to produce analyses and tools for their work. We’ll run our models and harnesses, at no cost to them. We’ll work together to open-source the resulting data, artifacts, and code, and write preprints about what we find.

We want humans to remain at the center of scientific discovery, deciding what questions to pursue, and how to pursue them. Those decisions are not ours to make alone. This open call is part of our ongoing efforts at Anthropic to support researchers and accelerate scientific discovery.

I’m looking for principal investigators and their research groups at academic institutions, nonprofits, or government labs, working in causal human biology, structural and computational molecular biology, medicinal chemistry, drug discovery, and clinical science.

Applications are open for about 14 days: https://t.co/bCcrKjB3W7

[Kyle Tretina, Ph.D. @AllThingsApx]

Need compute to compete in protein design competitions like this one?

https://t.co/fedrGMwq4d

RFD4-Proteina is now on Hugging Face with two weeks of NVIDIA-sponsored access. 🧵👇

[nature @Nature]

China has selected its first group of young researchers to receive funding for up to 15 years, in one of the longest research grants on offer to scientists globally

https://t.co/6RnYWeNs6e

[Simplifying AI @simplifyinAI]

Here's the link: https://t.co/2IZhovpfvk

If you want more practical ai gems and a list of full free ai resources, go here: https://t.co/V9tGVvGNzl

[Jun Cheng @s6juncheng]

We are offering 10,000 scientists the highest usage tier in Google Antigravity free of charge for 6 months. Please apply! https://t.co/ywWLNf4Q7q

[Karim Majzoub @KarimMajzoub]

Antiviral immunity via telomerase-like reverse transcription in bacteria https://t.co/h9U54RJXht

[Florian Krammer @florian_krammer]

Looks like an early flu season in the US.