Hornstein Lab

HornsteinLab @WeizmannScience | Mechanisms of Neurodegeneration | #ALS | #noncodingRNA | #phaseseparation | #neurogenetics | #biomarkers | computational biomed

[Hornstein Lab @HornsteinLab]

Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven 𝗡𝗢𝗩𝗔 (𝗡euronal 𝗢rganellomics 𝗩ision 𝗔tlas) encodes organelle patterns in 1.5M+ neuron images, enabling holistic insights in cellular biology
https://t.co/YQRxeGwLcm

[Hornstein Lab @HornsteinLab]

@DaninoYehuda @rolls_asya @TelAvivUni Good luck Yehuda, you will be highly missed and we wish you much success in Rolls lab

[Alzforum @alzforum]

TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine https://t.co/v7sqrROubN

[Hornstein Lab @HornsteinLab]

@IgorUlitsky Huge congratulations! 🎉

[ALS News Today @alsnewstoday]

Wearable robot gives ALS patients a hand https://t.co/yyPof3vYBk

#ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch

[medRxiv @medrxivpreprint]

IsomiR Utility in ALS Prognostication https://t.co/PokOwnl8rk #medRxiv

[Leeat Keren @leeat_keren]

Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

[Richard Sever @cshperspectives]

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] https://t.co/4siujZbXxF 1/n

[Hornstein Lab @HornsteinLab]

Excited to share our preprint: "𝐎𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐨𝐦𝐢𝐜𝐬: 𝐀𝐈-𝐝𝐫𝐢𝐯𝐞𝐧 𝐝𝐞𝐞𝐩 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐧𝐨𝐯𝐞𝐥 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐢𝐧 𝐡𝐮𝐦𝐚𝐧 𝐧𝐞𝐮𝐫𝐨𝐧𝐬"

[Nancy Yacovzada @NancyYaco]

🚀𝐕𝐢𝐬𝐢𝐨𝐧-𝐭𝐫𝐚𝐧𝐬𝐟𝐨𝐫𝐦𝐬-𝐛𝐚𝐬𝐞𝐝 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐮𝐧𝐯𝐞𝐢𝐥𝐬 𝐡𝐢𝐝𝐝𝐞𝐧 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬!

🧵 Thread on 𝘕𝘖𝘝𝘈 (𝘕𝘦𝘶𝘳𝘰𝘯𝘢𝘭 𝘖𝘳𝘨𝘢𝘯𝘦𝘭𝘭𝘰𝘮𝘪𝘤𝘴 𝘝𝘪𝘴𝘪𝘰𝘯 𝘈𝘵𝘭𝘢𝘴)🎗️ our deep-learning model trained with ~3M images of human-derived neurons, and newly discovered insights into ALS disease. We used AI to map cellular dysfunction at un unprecedented resolution, comprehensively studying all sub-cellular organelles.

Preprint: "𝐎𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐨𝐦𝐢𝐜𝐬: 𝐀𝐈-𝐝𝐫𝐢𝐯𝐞𝐧 𝐝𝐞𝐞𝐩 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐧𝐨𝐯𝐞𝐥 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐢𝐧 𝐡𝐮𝐦𝐚𝐧 𝐧𝐞𝐮𝐫𝐨𝐧𝐬"
https://t.co/qv29YjmwZi

Check out our code and data: https://t.co/8OH0u71sTq
1/n

[Neville Sanjana @nevillesanjana]

Delighted to share new work from our lab:
MultiPerturb-seq 🎛️❌📥📤

Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

[kakasloi @supramabuhay]

The pure joy in Gaza as Iranian missiles cover the sky above Tel Aviv.

[Alzforum @alzforum]

At AAIC 2024, phospho-tau assays look ready for primary and secondary care. @lunduniversity @wustl @BannerAlzheimer https://t.co/AMJNPgZpVX

[Hornstein Lab @HornsteinLab]

@medrxivpreprint This work is based on a pre-clinical study from the lab, by PhD student Dr. Anna Emde in @EMBO: https://t.co/cGrtKTkmro, and was performed in close collaboration with Dr. Angela Genge from @TheNeuro_MNI who ran the clinical trial.

[Hornstein Lab @HornsteinLab]

@medrxivpreprint Plasma and CSF throughout the entire treatment period of 30 days, supporting the use of microRNAs as a pharmacodynamic marker of target engagement. These results enocurage larger and longer trials to test Enoxacin efficacy in patients with #ALS.

[medRxiv @medrxivpreprint]

A phase Ib/IIa study of Enoxacin in patients with ALS https://t.co/DBtiw6YRqT #medRxiv

[Rahul Satija @satijalab]

Interested in 3' UTR changes in scRNA-seq? Check out our:
* CPA-Perturb-seq paper
* UCSC Perturb-seq tracks (see who regulates your favorite 3’ UTR!)
* Seurat extension for polyA site analysis (PASTA)
* Deep neural perturbation network (APARENT-Perturb)
https://t.co/XXYEBHV1iG

[Slava Bobrov @slava__bobrov]

Birth of a neuron. Stem cell transforming into a brain cell:

#neuroscience

[Slava Bobrov @slava__bobrov]

Human brain anatomy:

#neuroscience

[Nancy Yacovzada @NancyYaco]

My team is working with a substantial arsenal of ML algorithms, analyzing diverse human molecular data. The most intriguing work imaginable. We do science and study human brain diseases, but like a small startup.
Come join us!

[Hornstein Lab @HornsteinLab]

We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration.

Position details and requirements: https://t.co/he26W7fQX8

CV to [email protected] / [email protected]

#jobopportunity