Anna Howes

Thermo Fisher Scientific - Senior Applications Scientist - Structural Biology (cryo-EM) 🧬🥼

[Anna Howes @HowesAnna]

Delighted to share my first first-author paper in @ScienceAdvances 🥳We determined the structure of H2O2-activated ATM bound to p53 peptide substrate and suggest a mechanism for ATM activation by oxidative stress.🧵(1/11)
https://t.co/5sxL7nP1O4

[Sonya @sonyahans]

Announcing cryo-EM heterogeneity challenge #2, now dubbed the 2025 Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA)! Join us for a webinar next Friday (Nov 14th) to learn more. Datasets already posted here: https://t.co/fyrOLnELN5

[The Nogales Lab @NogalesLab]

We are excited to announce the first Salamanca Biophysics Summer Course organized by Carlos Bustamante (@BustamanteLab) and Eva Nogales (@NogalesLab ). See the flyer below and consider applying!

[Ernesto Arias-Palomo @EAriasPalomo]

Our experience with #alphafold3 🤖 (code recently released) and some of our most recent #cryoEM 🔬 structures (thread below) https://t.co/SmX8i15Zwa
https://t.co/hwJUlkwhye

[Claudio Alfieri @calfieri84]

I am looking for a highly motivated PhD student to join my lab @ICR_London , please help to spread the message: https://t.co/5QXVx3rkxP

[Anastasia Gusach @GusachAnastasia]

How to sense danger from afar?
Revised and refined, our paper on the insights into smell recognition by a mammalian trace-amine receptor from Cryo-EM, modelling and functional studies is finally out!
https://t.co/wJtnbHUwjT

[Yang Yang @yyang_cella]

🔬👩‍🔬 Exciting news! I'll soon start my lab @VAInstitute to research molecular mechanisms in Neurodegenerative diseases. 🧠💡 Now recruiting postdocs to join our dynamic research team! Email me if you're interested! #Postdoc #CryoEM #Neuroscience #ResearchOpportunity

[Stanislau Yatskevich @StanislauY]

Happy to see one of the last pieces of my PhD work published!

Very lucky to have awesome @TDendooven as a partner in crime

Also many thanks to @AlisterBurt, Dom, John, David and @RappsilberLab

[Alister Burt @AlisterBurt]

Sad to see: @vispyproject is, among other things, the rendering engine behind @napari_imaging. @djhoese has almost single handedly kept it working for the last few years.

The lack of money for scientific infrastructure like this is so short sighted.

https://t.co/NsVklNtOOv

[Luca Jovine → bsky.app/profile/jovinelab.org @lucajovine]

Capping a 10-year-long adventure, in today's @CellCellPress we unveil the molecular mechanism whereby the fertilized egg permanently blocks polyspermy, a lethal condition for the embryo:

https://t.co/T0MNqBJ6FU

#structuralbiology #reproduction #fertilization #infertility

[Stanislau Yatskevich @StanislauY]

Happy to see our work on the structure of the outer kinetochore in print
https://t.co/VvKmx2snJy

Special thanks to David, Dom, @JYang188 and @ZhangZiguo

Glad to see the complementary study by @AndreaMusacchi1,@polley_dilse and @TobiasRaisch in the same issue! Congratulations 🎉

[The Nogales Lab @NogalesLab]

We have received a lot of requests for help with making streptavidin affinity grids. We are happy to finally share our protocol for robust in-house fabrication of streptavidin affinity grids. Stay tuned for the accompanying video that is coming soon!
https://t.co/6IA1u7RRqg

[Dr Katharine Hubbard @KEHplantsci]

OK #Science twitter - do your thing! We have written an open letter to Conservatives strongly opposing 'kicking woke ideology out of science' rhetoric & show they do not represent science. Please distribute widely! Screen readable text + signature form at https://t.co/H7rNzb0wGh

[Itai Yanai @ItaiYanai]

There’s this unfortunate myth in science that the head of the lab alone controls its culture. In reality, all the members do and so each person should realize that they bring their own values, attitudes, and spirit for how things should be and that this does matter quite a bit.

[Anna Howes @HowesAnna]

Congratulations @StanislauY, very well-deserved for all of the fantastic work you have achieved!!! 🎉

[Anna Howes @HowesAnna]

@GiuliaManigras1 @ScienceAdvances Thanks so much Giulia!!

[Anna Howes @HowesAnna]

Delighted to share my first first-author paper in @ScienceAdvances 🥳We determined the structure of H2O2-activated ATM bound to p53 peptide substrate and suggest a mechanism for ATM activation by oxidative stress.🧵(1/11)
https://t.co/5sxL7nP1O4

[Anna Howes @HowesAnna]

Massive thank you to @rlwster lab members and @MRC_LMB facilities for all the support. As a last note, this work was only started later in my PhD, so if something isn't working out (as my first project didn't), it really can be worth switching projects! (11/11)

[Anna Howes @HowesAnna]

There is more work in the paper that cannot be summarised in this thread, so please check it out! (10/11)