ICMUB

Institute of Molecular Chemistry @CNRS UMR6302 @dijon @univbourgeurope

[ICMUB @ICMUB]

How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation
Now in Nucleic Acids Res.: https://t.co/Ngb7mMUvK5
With @NJU1902 & @Polytechnique
@CNRS

[ICMUB @ICMUB]

An ICMUB team has simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s
The TASQs story @ACSPublications: https://t.co/rXR0XFZBnd
This new article @ChemEurJ: https://t.co/Wb3tu3tJ7P

[ICMUB @ICMUB]

A novel biotechnological application for DNA G-quadruplex #G4, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner
Now in Anal. Chem.: https://t.co/a1LgElJtnD

[ICMUB @ICMUB]

The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down)
Now in ACS Bio & Med Chem Au: https://t.co/zYk5LGim9m

[ICMUB @ICMUB]

A novel collaboration between @icmub (FR) and @NJU1902 (CN) which keeps on expanding the repertoire of biotechnological applications of G-quadruplex #G4, here to track undesired antibiotics in food.
Now published in @an_chem
👉 https://t.co/SsYqY9korK

[ICMUB @ICMUB]

An interview of D. Monchaud, @CNRS researcher @icmub now published @PourlaScience to discuss about the results of Simon Elsässer and @PKnipscheer recently published in Science
👉https://t.co/ya8CHckdfk

👉https://t.co/Cj69w6faEd
(sorry, in French only)

[ICMUB @ICMUB]

A fruitful collaboration between @icmub (FR) and @iitgn (IN) supported by @EMBOFellows led to a novel strategy to fight against colorectal cancer, which relies on the pharmacomodulation of G-quadruplex #G4 found in miRNA.
Now published in @BMCBiology https://t.co/bnEe5UXnSv

[ICMUB @ICMUB]

A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) made in @ICMUB
In collaboration with @UBI_pt and @WesternU
👉https://t.co/Y4fRfIt3fG

[ICMUB @ICMUB]

ICMUB is proud to have been associated with the very 1st meeting on DNA/RNA junctions IMAJ#1 organized by @dmonchaud.bsky.social and funded by @CNRSchimie (IRN). The meeting took place in Paris from 12 to 14 May, 2025 and was a real success! Great talks and enriching discussions!

[ICMUB @ICMUB]

@icmub was associated to a consortium steered by @crctoncopole to decipher how G-quadruplex #G4 RNA can be leveraged for mitochondrial translation-targeted therapy to fight against cancers
Now in @NatureComms👍
@CNRSchimie @CNRS_Centre_Est @univbourgogne
https://t.co/NJqKdetdvW

[ICMUB @ICMUB]

In this new @J_A_C_S article, a collaboration between @ICMUB, @NanjingUnivers1, @Polytechnique and @univ_spn report on CoRP-seq, a technique that allows for mapping RNA G-quadruplex #G4 transcriptome-wide in a faster, cheaper and simpler manner!
👉 https://t.co/6nFpKijNWz

[ICMUB @ICMUB]

In this @STARProtocols article, J. Mitteaux & D. Monchaud from @icmub describe in a step-by-step manner how to fish RNA G-quadruplex #G4 out from human cells using commercially available TASQs, either BioCyTASQ (https://t.co/Ryw704F8T7) or MultiTASQ (https://t.co/gV5Jgpww59)

[ICMUB @ICMUB]

Another beautiful collaboration between @ICMUB and @UTHealthHouston @McGovernMed which aims at deciphering the roles that G-quadruplex #G4 DNA and RNA play in human cells using chemical biology means.
@CNRS @CNRSchimie @univbourgogne

[ICMUB @ICMUB]

A free-flowing and spirited discussion on @icmub research related to DNA structure oddities (G-quadruplex, #G4) that may have a profound impact on our daily lives (aging and age-related diseases).
Thanks to the CNRS (@CNRS @CNRSchimie @CNRS_Centre_Est) for this opportunity

[CNRS Chimie @CNRSchimie]

#chimie ⚗️ #ResultatScientifique 📕 🔎 l Une nouvelle cible #thérapeutique prometteuse sur l’ADN de cellules #cancéreuses et des molécules capables de s'y attaquer de manière sélective.

🤝 @univbourgogne @CNRS_Centre_Est @dmonchaud
➡️https://t.co/MYKUAXXWXh

[ICMUB @ICMUB]

‼️highlight alert‼️
Thanks @CNRSchimie for highlighting this @icmub work done in collaboration with @agranzhan @institut_curie @SebBritton1 @IpbsToulouse Nicolas Chéron @Chimie__ENS and Lukas Trantirek @CEITEC_Brno

[ICMUB @ICMUB]

An @icmub contribution aiming at deciphering the roles that a peculiar DNA structure known as G-quadruplex #G4 plays in a neurodegenerative disease (XDP) published in @NAR_Open 👍👍👍
@CNRS @CNRSchimie @CNRS_Centre_Est @univbourgogne

[RichterLab Unipd @RichterLabUnipd]

We are so proud to share our latest work on G-quadruplexes in the XDP neurodegenerative disorder, led by our postdoc @GiuliaNicolez, in collaboration with @ccxdp @dmonchaud and @GSchotta
👉https://t.co/gAaejkDK5A
@SaraNRichter_ @DMM_Unipd @LMU_Muenchen @ICMUB @MassGenBrigham

[Angewandte Chemie @angew_chem]

Structural Optimization of Azacryptands for Targeting Three-Way DNA Junctions (David Monchaud and co-workers) @agranzhan @institut_curie @dmonchaud @icmub @CNRSchimie #openaccess https://t.co/TUDFycpscq

[ICMUB @ICMUB]

An historical perspective on DNA interacting compounds used as anticancer agents, written by an @icmub @univbourgogne @CNRSchimie member in honour of Prof. Stephen Neidle @ucl @School_Pharmacy @ucllifesciences

[ICMUB @ICMUB]

Targeting DNA junctions for fighting against cancers!
An @icmub work in collaboration with Paris, Toulouse and Brno (CZ). Congrats to all authors!
@univbourgogne @CNRSchimie