Gunnar Schotta

Professor for Epigenetics @ LMU Munich,
interested in chromatin, endogenous retroviruses and transcription factor biology

[Gunnar Schotta @GSchotta]

Setdb1 silences ERV derived cryptic enhancers to ensure proper hematopoiesis. Although transcription factors, such as PU.1, can bind to H3K9me3 heterochromatin, their activity is inhibited by Setdb1.
out in PNAS: https://t.co/ZWwKLghHmL

[Gunnar Schotta @GSchotta]

@JakobssonLab @M_Vincendeau @ch_douse Great story! Interesting that loss of DNMT1 de-represses LINE1 while "silencing mark" H3K9me3 is maintained. Much like we found in mouse endoderm IAPEz elements are derepressed in Dnmt1 ko with maintained H3K9me3 https://t.co/1VeJzuvqsp

[Gunnar Schotta @GSchotta]

@ControllingLMNT @LickertHeiko @NatureComms I think there will be heterogeneity. For example, an IAP element in the Mnd1 locus seems specifically regulated in neuronal cells (PMID 22991445,27798843), but not in XEN or DE cells. Maybe due to differences in TF networks. Will need to investigate better...

[Gunnar Schotta @GSchotta]

H3K9me3 is not sufficient for silencing endogenous retroviruses if DNA methylation is perturbed. In Dnmt1 ko endoderm cells, IAP elements fully maintain H3K9me3, while trancriptionally active.

great collaboration with @LickertHeiko

out in @NatureComms
https://t.co/1VeJzuvqsp

[Gunnar Schotta @GSchotta]

@ControllingLMNT @LickertHeiko @NatureComms Very good question. Unfortunately read mapping on individual IAPs is challenging due to strong homology/identity between elements. Long read sequencing will help to clarify this better.

[Gunnar Schotta @GSchotta]

@TheBraunLab @LickertHeiko @NatureComms Thank you! And congrats to your nice Lem2-exosome story!

[Gene Regulation @generegulation]

DNA sequence-dependent formation of heterochromatin nanodomains [Graeme Thorn, Christopher Clarkson, Anne Rademacher, Hulkar Mamayusupova, Gunnar Schotta, Karsten Rippe & Vladimir Teif] https://t.co/O9RsdhIh3T
ChromHL software here: https://t.co/pq7DX8tdKC
Cartoon as a bonus!

[Michelle Vincendeau @M_Vincendeau]

Here is our Snapshot of Human Endogenous Retroviruses (HERVs) that I wrote together with @JakobssonLab for Cell (@CellCellPress). Enjoy reading here: https://t.co/fWgKQ70ruU - @HelmholtzMunich @Lund_Stem

[Gunnar Schotta @GSchotta]

@simonelsasser Thank you @simonelsasser. Much appreciated :-)

[Gunnar Schotta @GSchotta]

G-quadruplexes are cell type-specific and associated with high transcription. Great collaboration with @RichterLabUnipd @SaraNRichter_

[Sara N. Richter @SaraNRichter_]

Check out our latest research on how G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome.
https://t.co/wSZUeYkeEc
@GSchotta @FCernilogar @RichterLabUnipd

[Gunnar Schotta @GSchotta]

Morc3 silences endogenous retroviruses by enabling Daxx-mediated H3.3 incorporation. Morc3 GHKL ATPase domain dimerizes for Daxx interaction. An efficient ATPase cycle is critical for H3.3 incorporation. https://t.co/c08eXanPZ7

[Gunnar Schotta @GSchotta]

HIV infection activates ERVs to regulate antiviral gene expression. Great collaboration headed by Daniel Sauter! https://t.co/TPPekrV1zg

[Gunnar Schotta @GSchotta]

G4 quadruplex structures are cell type specific and associate with highly expressed genes. New preprint of a collaborative project led by @SaraNRichter_ https://t.co/4jv9reyyjf

[Barbara Schraml @buschraml]

Ever wonder why children react differently to pathogens? Join our lab and help us find out! https://t.co/aTJFo2Wbsp

[JASN_News @JASN_News]

The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties @buschraml @gschotta @FCernilogar
https://t.co/TtXRrysNes