Sébastien Britton

Group leader of the DDR lab at Toulouse #CNRS. Science addict. Chemical biology and Genomics to find new druggable targets to treat #cancer

[Akis Papantonis @AkisPapantonis]

The @RoukosVassilis lab led a new and detailed study of Topoisomerase II contribution to #3Dgenome folding in human cells and in different cell cycle phases -- my group and the @MundlosLab contributed analyses/data. The paper is now published in @MolecularCell ...1/n

[ICMUB @ICMUB]

‼️highlight alert‼️
Thanks @CNRSchimie for highlighting this @icmub work done in collaboration with @agranzhan @institut_curie @SebBritton1 @IpbsToulouse Nicolas Chéron @Chimie__ENS and Lukas Trantirek @CEITEC_Brno

[jobRxiv @jobRxiv]

Group leader in Infection Biology @IpbsToulouse

The IPBS-Toulouse recruits a Group leader in Infection Biology

https://t.co/FOfI5s86aB

#ScienceJobs #job
https://t.co/FOfI5s86aB

[Priyanka Sharma @psharmalab]

If you are a bright Ph.D. student working outside France around our research theme https://t.co/JaTlohuc7W @IpbsToulouse , here is a chance for you to contact us to apply for the open Excellence Eiffel Fellowship https://t.co/2P0ALTdeml
contact us before October 20th, 2024 !!

[Jacqueline Jacobs @jacqjacobs1]

Come join us as a postdoc in the JaJa lab at the Netherlands Cancer Institute if you are interested in the molecular mechanisms underlying telomere maintenance by ALT and in findings ways how to target ALT in pediatric cancer treatment.https://t.co/OVNkGxO5h5

[Priyanka Sharma @psharmalab]

Our lab, @IpbsToulouse is looking for a motivated research engineer with fluency in French and English, interested in our research theme, https://t.co/JaTlohuc7W. Please apply here: https://t.co/SE3V0n9enQ
Please retweet 🙏

[CNRS Biologie @CNRSbiologie]

#ResultatScientifique 🔎 | Du nouveau sur la régulation des mécanismes de réparation de l’ADN

🤝 @CNRS @CNRS_Toulouse @UT3PaulSabatier @IpbsToulouse
✍️ @SebBritton1
📕 @CellReports | https://t.co/NYaXg7gB9O
https://t.co/ZUqo7WdAOn

[Ci Ji Lim @cijilim]

1/7 Our latest preprint is out! 🚨 @Sour_Agrawal , @xiuhua_linwisc , @viveksusvirkar et al. discover human RPA is a critical telomerase processivity factor essential for telomere maintenance. This reshapes our understanding of human telomerase regulation. https://t.co/HJkap1APl4

[Erman KARASU @karasuerman1]

Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: https://t.co/0ck5FHVXvb

[Vincenzo DAngiolella @VdangioE3lab]

Our latest manuscript on a new cell cycle dependent control of dna repair. Started from a high resolution crispr screen of #ubiquitin system after IR: check table S2!
Also substrates of cyclin f through motif search!
https://t.co/foGAoXwwu7

[bioRxiv Genomics @biorxiv_genomic]

Optimized methods for mapping DNA double-strand-break ends and resection tracts and application to meiotic recombination in mouse ... https://t.co/ARoAwz5gZC #biorxiv_genomic

[Chowdhury Lab @ChowdhuryLab]

Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers!

https://t.co/a09GX4ipAi

[Cortés Lab @CortesLab]

🔥🔥🔥 PREPRINT 🔥🔥🔥

Wanna know how your favorite gene affects double-strand break repair outcome/CRISPR-Cas9 gene editing?

Check this out! ⬇️ #REPAIRome

https://t.co/KDHs1TWoQn

[Sébastien Britton @SebBritton1]

@ocalvayrac 😊 Thanks Olivier!

[Sébastien Britton @SebBritton1]

In vitro, multiple #DNA_repair proteins Ku load from DNA ends on linear DNA, eventually covering it. Yet, in cells, only one Ku is found per DNA end at double-strand breaks. What restricts Ku entry on chromatin? https://t.co/RpQHFVdvmN

[Sébastien Britton @SebBritton1]

@AgneseCristini Thanks Agnese!

[Sébastien Britton @SebBritton1]

@DrBillonPierre Thank you Pierre !😊@MadeleineBsrt did a terrific work!

[Sébastien Britton @SebBritton1]

Really proud of this one! Thanks to our collaborators @JoeLoparo lab for single-molecule experiments in Xenopus egg extracts, the kind reviewers, @CellReports for the pleasant publishing experience, and our funders @Liguevscancer31 @laliguecancer @FRM_officiel

[Sébastien Britton @SebBritton1]

In this work, we identify the main barriers to Ku accumulation in chromatin: DNA-PKcs structurally retains Ku at DNA ends. If Ku enters chromatin, it is removed by a neddylation/FBXL12-dependent process. In S-phase, DNA end resection can remove Ku, even in excess.

[Sébastien Britton @SebBritton1]

These mechanisms are crucial: transcription is inhibited locally by Ku without DNA-PKcs, and FBXL12 is vital for the fitness of DNA-PKcs deficient cells. Our findings highlight the complex regulation of Ku, necessary to maintaining genome integrity.