IOCBioNMR

Biomolecular NMR at IOCB Prague

[Vaclav Veverka @vaclav_veverka]

Exploring unsettled biomolecular interactions with an NMR twist. A joint effort with the Obsil lab. @IOCBioNMR https://t.co/LTV2B2eyzs

[IOCB Prague @IOCBPrague]

#research #structuralbiology #chromatin #LEDGF #cryoEM

Multivalency of nucleosome recognition by LEDGF (@vaclav_veverka) - @nar_open: https://t.co/kBNO93zlU3

@eshusha @IOCBPrague @science_charles

[Vaclav Veverka @vaclav_veverka]

Although we were not successful in resolving the central IDR from LEDGF bound to nucleosomal DNA using #cryoEM, we stumbled upon an unexpected H3K36 methylation-independent docking site for its PWWP domain. This story was just published in @NAR_Open and is summarized by @eshusha

[Vaclav Veverka @vaclav_veverka]

We are looking for a PhD student to join our lab at @IOCBPrague to study chromatin associated complexes. #structuralbiology
#nmr #cryoem #transcription #epigenetics @iocbionmr https://t.co/K5tGfbhtz5 https://t.co/drLk1pSZPD

[Katerina Cermakova, cermakova.bsky.social @katacermaku]

Our awesome collaboration with @vaclav_veverka @hodgeshc @AdelmanLab @zegerdebyser @zeunas @PavelSrb Vanda Lux + many others was just published in Science, where we reveal new roles of unstructured protein in transcription. (1/8) https://t.co/u49IVZZf5E

[Vaclav Veverka @vaclav_veverka]

Katerina Cermakova, Jonas Demeulemeester (@zeunas) and Vanda Lux - you have done an amazing job - big respect! Great support from all co-authors! @IOCBPrague @bcmhouston @KU_Leuven @harvardmed @science_charles
@ScienceMagazine: https://t.co/Ro7y7Ot25b
https://t.co/3WXj3AGUqd

[IOCB Prague @IOCBPrague]

Researchers led by @hodgeshc @bcmhouston & @vaclav_veverka @IOCBPrague discovered how disordered protein interactions coordinate the assembly of proteins controlling gene expression.

@sciencemagazine: https://t.co/zuK6GVksR8

Full story: https://t.co/VLLeaCkKRF

[Angewandte Chemie @angew_chem]

What is Edward Curtis' @IOCBPrague favorite place on earth? Find out on his #IntroducingAngewandte page https://t.co/4EBGSyurhV https://t.co/ovo2PKOQBr

[Vaclav Veverka @vaclav_veverka]

Stellar glowing DNAzyme from the #Curtislab @IOCBPrague. Awaiting future exciting applications! Congratulations

https://t.co/i0lG1lHgp9

[IOCBioNMR @IOCBioNMR]

With a careful experimental design, one round of selection can lead to functional deoxyribozymes. Excellent idea!

[Vaclav Veverka @vaclav_veverka]

Accelerated deoxyribozyme evolution. Experimental proof of a clever idea. Well done #Curtis lab @IOCBPrague https://t.co/K7fqCZiJHf

[Magnetic Resonance News @nmr900]

. @SciReports (open) N-Glycosylation can selectively block or foster different receptor–ligand binding modes, Joni Vuorio, Jana Škerlová, Milan Fábry, Václav Veverka, Ilpo Vattulainen, Pavlína Řezáčová & Hector Martinez-Seara* @IOCBPrague https://t.co/RQzWGBLG3c #NMRchat #NMR

[IOCBioNMR @IOCBioNMR]

It's so exciting to follow the research progress on a protein that spent its early days in the NMR tube. DDI2 has an important role in proteostasis, as shown in vivo by our colleagues from @Konvalinka_Lab @IOCBPrague #proteasome #ubiquitin #immunity

https://t.co/iMZD1lRV9D

[IOCBioNMR @IOCBioNMR]

Our structural work in the new paper.

[Vaclav Veverka @vaclav_veverka]

Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival https://t.co/7Y1oddEurM via @MDPIOpenAccess @IOCBioNMR @hodgeshc

[MarianNovotny @majek_n]

Tento čtvrtek budeme s Davidem Hokszou z @matfyz a @vaclav_veverka z @IOCBPrague diskutovat v live stream (https://t.co/COdYoJx7i8) o průlomu v predikci proteinové struktury a jeho důsledcích. Přidejdte se ! #AlphaFold #casp14 @UniKarlova

[IOCBioNMR @IOCBioNMR]

Never used so many biophysical techniques in one project...from paramagnetic NMR through AUC and X-ray crystallography to mass spectrometry.

[Vaclav Veverka @vaclav_veverka]

Officially a structural biologist. Congratulations Vanda!

https://t.co/71m2idtKpn

[IOCBioNMR @IOCBioNMR]

CK2 regulatory role for LEDGF interactome confirmed!

[Vaclav Veverka @vaclav_veverka]

Paradox role for LEDGF/p75: Competition between PAF1 and MLL1/COMPASS confers the opposing function of LEDGF/p75 in HIV latency and proviral reactivation https://t.co/QCqQSdmUc3

[Vaclav Veverka @vaclav_veverka]

@IOCBioNMR contribution to understanding the calcium sensing mechanism by the transmembrane segment of Bordetella adenylate cyclase toxin @BBAjournals #biomembranes. https://t.co/qYSuPc6zQF

[IOCBioNMR @IOCBioNMR]

N-glycosylation caught responsible for modulating receptor-ligand interactions @IOCBPrague https://t.co/fL0eOphs31

[IOCBioNMR @IOCBioNMR]

Excellent science!

[Kvido Strisovsky @KvidoStrisovsky]

Our new paper in @embojournal: on a bacterial rhomboid protease and its ancestral pseudoprotease function analogous to rhomboid‐family client adaptors in eukaryotic ERAD. Great collaboration with @IOCBioNMR and @doan_thierry! https://t.co/1gfPpEHE0W

[IOCB Prague @IOCBPrague]

Please RT – #PhD @IOCBPrague - Check 35 available #PhDprojects in 18 IOCB groups from CHEM, BIO, and PHYS clusters including @PetrBeier @hocekm @CahovaB @Konvalinka_Lab @tomas_pluskal @IOCBioNMR labs:
https://t.co/xfajHoQQtm