Jerome Nwachukwu

PhD | Scientist @UFScripps #NuclearReceptors #BreastCancer #BlackInSTEM 👉🏽 Thoughts expressed are mine, not yours.

[Stephen Turner 🦋 @stephenturner.us @strnr]

Genome access is transcription factor-specific and defined by nucleosome position https://t.co/znbnpsq6ht

[Jonathan Kagan @jkagan1]

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome.
https://t.co/J9xnnt0xXD

[Isomorphic Labs @IsomorphicLabs]

We're excited to announce #AlphaFold 3 with @GoogleDeepMind in @Nature: our new AI model for predicting biomolecule structures with unprecedented breadth and accuracy.

Expanding beyond proteins to tackle DNA, RNA, small molecules to fuel advances in biology & drug design 🧵

[Cell Metabolism @Cell_Metabolism]

New! Online now: Immunological regulation of skeletal muscle adaptation to exercise https://t.co/Pz2TQXvYf3

[Jerome Nwachukwu @JCnwachuk]

@biorxivpreprint Over 75% of #breast #cancer cases are driven by this estrogen receptor, and many breast cancer drugs are designed to inhibit its activity. This work gives us a better understanding of how the receptor actually works. #NuclearReceptors #CancerResearch

[bioRxiv @biorxivpreprint]

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu https://t.co/1H0wuedJXK #bioRxiv

[Molecular Cell @MolecularCell]

Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle https://t.co/qWqQPVNslR

[Molecular Cell @MolecularCell]

Online Now: Transcription factor exchange enables prolonged transcriptional bursts https://t.co/P2F92skgCW

[bioRxiv @biorxivpreprint]

AlphaFind: Discover structure similarity across the entire known proteome https://t.co/R74Yeg7DqK #bioRxiv

[Cell Reports @CellReports]

Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation https://t.co/q69kE6GQcs

[Stefan Prekovic @Stefan_Prekovic]

Proud of our latest study highlighting the glucocorticoid receptor's (GR) key role in primary cancer biology, especially in determining ER-positive breast cancer subtypes and patient outcomes. Full details in the thread 🧵👇 @EmboMolMed @NKI_nl @UMCU_CMM https://t.co/4puyxm2IDw

[Jerome Nwachukwu @JCnwachuk]

FYI, undergrads:
https://t.co/YtwbFDLpV6

[Eric Topol @EricTopol]

How to train our immunity, not just against infectious diseases but also vs cancer, autoimmune conditions https://t.co/m8zeimuWM9 @cellhostmicrobe @Radboud_Uni

[NYU Grossman School of Medicine @nyugrossman]

NYU Langone Health researchers found that collecting genetic information from seemingly healthy tissue near lung tumors may be a better predictor of cancer recurrence after treatment compared to analyzing the tumor itself.

Learn more: https://t.co/l0zWRc2hZH

[Molecular Cell @MolecularCell]

Online Now: N6-methyladenosine in 7SK small nuclear RNA underlies RNA polymerase II transcription regulation https://t.co/aQU4g3gaBN

[Molecular Cell @MolecularCell]

RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression https://t.co/FKnUmYbPgF

[Prof Inés Pineda-Torra 🇪🇺🇪🇸🇺🇦 @inespinedatorra]

📢📢📢
We have 🌟fully funded postdoc positions🌟 in my group in Sevilla, a beautiful city with one of the best quality of life.

Interested in metabolism? Cardiovascular disease? Sex hormone regulation? Sex differences in cardiovascular risk?
Look no further!
Get in touch!

[Science Magazine @ScienceMagazine]

"The United States needs to rethink its entire innovation ecosystem to incorporate equity as a foundational guiding principle," @KeithWailoo, @VictorDzau, and @kryamamoto argue a new #ScienceEditorial. https://t.co/KVkNjh5rCF

[Molecular Cell @MolecularCell]

Control of mRNA fate by its encoded nascent polypeptide https://t.co/SeqD9N1Sym

[Genentech @genentech]

In @NatureComms, our scientists describe how inhibiting TGFβ and PD-L1 enhances immune responses by aiding in the replacement of defective T cells. Read the authors' blog to learn how this research may inform strategies to help cancer patients: https://t.co/ycNfjuOCu5