J R Biomedical Ltd

UK biotech company with a focus on sepsis biomarkers of the innate immune system. Follow us for our R&D updates #immunology #sepsis #innateimmunology

[Andrew Bowie @Agbowie1]

Pathogen manipulation of TLRs:- S aureus activates TLR2 endosomal signalling to promote intracellular survival. Great to collaborate with ⁦@McLoughlin_Lab⁩ on this study https://t.co/Z7jvDYa89h

[Journal of Experimental Medicine @JExpMed]

Wenjie Zhu, Xiaoyan Xu, Rachel Caspi @rcaspi @NatEyeInstitute @NIH et al. show that Vγ6 γδ T cells sense commensals via TLR2 to fuel IL-17A-mediated barrier defense at the ocular surface. https://t.co/d3nJgCNf9w

From our #InnateImmunity collection: https://t.co/zMAInsbCRM

[Harry Spoelstra @HarrySpoelstra]

Convalescent COVID-19 monocytes exhibit altered steady-state gene expression and reduced TLR2, TLR4 and RIG-I induced cytokine expression

😢You’re wondering why, after SarsCoV2 infections, you’re more susceptible for other infections?

➡️A new study confirming earlier findings: Dysfunctional immune response!

➡️“Data suggest that following SARS-CoV-2 infection, monocytes exhibit altered steady-state gene expression and reduced responsiveness to innate immune receptor activation.

➡️“As both RIG-I and TLRs recognise components of SARS-CoV-2, this may lead to a moderated inflammatory response to SARS-CoV-2 reinfection in the months following the initial infection.”

➡️“This downregulation of the activity of some innate immune receptors but not others may simply adjust the inflammatory response to some infections, rather than deactivating it.”

➡️“A clinical consequence of a sustained decrease in the response of these pattern recognition receptors could also be an increased susceptibility to other bacterial and viral infections”…….as we’re witnessing worldwide: TB for one!

The immunological consequences suggest that after SARS-CoV-2 infection, monocytes undergo changes in their baseline gene expression and show a diminished response to activation by innate immune receptors, potentially affecting the overall and broader immune response.
https://t.co/bK1YBsmQAP

[Hematopoiesis News @Hema_News]

Using ligands directed at the Toll-like family receptors (TLR) in models of high-risk #AML, Dr. Sara Meyer's team uncover that TLR2 ligands exert unique anti-#leukemic effects that are distinct from other TLRs. | @BloodPortfolio

🔎 Read it here: https://t.co/ZTvoOLnjlP

[J R Biomedical Ltd @JRBiomedical]

Meet us on the Welsh Goverment stand at #MEDICA in Dusseldorf this November. Find out more about the new sTLR2 RAPID - a 10 minute point-of-care test with applications in sepsis and inflammation.

#MedTech
#Sepsis

[Nicholas Fabiano, MD @NTFabiano]

The spike protein, one of the critical structural proteins of SARS-CoV-2 mediating cell entry, has been shown to affect endothelial function in vitro and in vivo inducing Toll-like receptor (TLR) 2 or TLR4-mediated inflammatory responses after systemic injection. 4/10

[Journal of Investigative Dermatology @theJIDJournal]

A review by Marco Lebtig, Andreas Peschel, & Dorothee Kretschmer, "Role of formyl peptide receptor 2 and toll-like receptor 2 in skin barrier function and atopic dermatitis" https://t.co/uQyxxsjt0L #JIDJournal #DermatologyJournal #dermatology #dermatologists #dermresearch #dermscience #dermatologyresearch #openaccess

[J R Biomedical Ltd @JRBiomedical]

The measurement of soluble Toll-like receptor 2 has applications in sepsis, inflammation and other diseases. The imiwn sTLR2 RAPID is a simple, semi-quantitative 10 minute test for use with plasma, serum and whole blood. Find out more at https://t.co/U13SrLMrAs

[YonkerLab @LaelYonker]

At #AAP2025! Excited to talk about a monocyte biomarker for early detection of #sepsis in kids!
Also- love the incredible community of pediatricians here!

[World Health Organization (WHO) @WHO]

It’s World #Sepsis Day
Sepsis kills 11 million people each year.

Symptoms incl.:
🔸Fever or shivering
🔸Confusion
🔸Shortness of breath
🔸Rash that does not fade when pressed
🔸Extreme discomfort
🔸Sweaty skin

Seek medical care as soon as possible when an infection is not getting better.
Learn more https://t.co/9pehRVmfrV

[J R Biomedical Ltd @JRBiomedical]

Soluble Toll-like receptor 2 (sTLR2) is a key plasma component of the innate immune response acting as a down regulating soluble decoy receptor during inflammation and #sepsis https://t.co/GNNGGzox6C

[J R Biomedical Ltd @JRBiomedical]

Join us on the Welsh Government stand @MEDICATradeFair this November and find out more about our sepsis and inflammatory disease biomarker rapid test 🔬👩‍⚕️
#sepsis
#MEDICA
#imiwn

[BSI Clinical Immunology Professional Network @BSI_CIPN]

Today is the final day to submit your abstract for #BSICIPN25!

You can submit under the categories of #allergy, #diagnostics, #immunodeficiency, #inflammation, #public and #patient engagement, or other.

Submit before midnight tonight (BST): https://t.co/bYtB3tLBy3

[J R Biomedical Ltd @JRBiomedical]

We're back on X! Follow us for updates on our new soluble-Toll-like receptor 2 rapid test for #sepsis and #inflammation

[J R Biomedical Ltd @JRBiomedical]

We have a temporary vacancy with our medical kit assembly team this summer 9am to 1pm Monday to Friday. To apply, please email a CV and/or brief details as to why you would be interested in the position. Closes 24th July #denbighshire #rhyl #denbigh #StAsaph pls RT

[J R Biomedical Ltd @JRBiomedical]

As the UK distributor for Danish biotech MotilityCount ApS we are pleased to announce the launch of the SpermCare food supplement to help maintain healthy sperm quality #fertility #maleinfertility https://t.co/GzzqBZDimV

[J R Biomedical Ltd @JRBiomedical]

COVID-19 (SARS-CoV-2) Nucleocapsid (N) protein significance in serology diagnosis used in COVID-19 (SARS-CoV-2) ELISA https://t.co/reIAfpfZpK

[J R Biomedical Ltd @JRBiomedical]

Our COVID-19 CE certified antibody ELISA kits for detection of IgA, IgG and IgM antibodies now available for laboratories online from JR Biomedical Ltd. Spec/Sens IgG 99.2%/100% 12 days post symptoms https://t.co/kkC7J87WZg

[J R Biomedical Ltd @JRBiomedical]

New ELISA serology IgG, IgM and IgA kits for COVID-19 are now available from JR Biomedical in #NorthWales - CE marked for laboratory use.

[J R Biomedical Ltd @JRBiomedical]

@longitude_prize @mologic @JosephFitchett Good luck @mologic with the development of the rapid #coronavirustest